Time to Prep for Colonoscopy? Here’s What You Should Know

Every day, Americans prep for a colonoscopy. The American Cancer Society anticipates more than 150,000 of them will be diagnosed with colon or rectal cancer in 2026. For others, this screening tool helps find polyps, growths that can become cancer. 

“A colonoscopy is an incredibly important exam that looks inside your colon to detect polyps,” says Dr. Felice H. Schnoll-Sussman, professor of clinical medicine, Division of Gastroenterology, and director of the Jay Monahan Center for Gastrointestinal Health at Weill Cornell Medicine/NewYork-Presbyterian. “By identifying these polyps and taking them out at the time of the colonoscopy, we can actually help someone avoid getting colon cancer.”  

Should You Prep for a Colonoscopy? 

While other tests can detect colon or rectal cancer, colonoscopy remains the gold standard. In fact, if other tests indicate cancer, a colonoscopy is necessary for diagnosis. Knowing when to prep for and undergo a colonoscopy helps you detect cancer early. 

If you’re at average risk, your first colonoscopy should take place at age 45. You can then repeat the exam every decade if nothing abnormal is found.  

If you’re at increased risk for colorectal cancer, you may benefit from earlier or more frequent testing. Your risk increases with the following: 

  • Family history of colorectal cancer 
  • Genetic predisposition for colon or rectal cancer 
  • Personal history of colorectal cancer or specific types of polyps 
  • Radiation exposure to the abdomen or pelvis 
  • Ulcerative colitis, Crohn’s disease or other inflammatory bowel disease 

How to Prepare for a Colonoscopy 

“The most important thing is that the inside of the colon is clean so the physician can identify all the polyps and take them out,” Dr. Schnoll-Sussman says. “Complying with all the instructions is probably one of the most important things you can do to prep for your colonoscopy, so you get clear test results.” 

In the days leading up to your screening test for colorectal cancer, prep instructions may include the following: 

  • Stop medication. Ibuprofen, blood thinners and other medications can increase your risk for bleeding and other complications. Your doctor may have you stop taking these a week beforehand. 
  • Go low-fiber. A few days before your colonoscopy, it’s good to follow a low-fiber diet. That means no whole grains, seeds or fruits and vegetables with seeds or skin. 
  • Clear your colon. During the final 24 hours before your exam, you should avoid solid foods and be on a liquid diet. Along with drinking only clear liquids, you’ll take medication that will cause you to have multiple bowel movements. Your doctor may tell you not to drink or eat at all the morning of your procedure. 
  • Recruit help. Have a family member or friend accompany you to your colonoscopy. This person should drive you home, since you’ll receive sedatives for your exam. 

“Colonoscopy is a safe, extraordinarily effective test,” Dr. Schnoll-Sussman says. “Many people wake up afterward and cannot believe the test is done.”  

Quick Facts on Getting Ready for Your Colonoscopy  

Colorectal cancer affects tens of thousands of Americans every year. Colonoscopy can detect it early or even prevent it. 

  • If you’re at average risk for colorectal cancer, you can undergo your first colonoscopy at age 45.  
  • You should consider undergoing a colonoscopy earlier than 45 if you have a family history of colorectal cancer or other risk factors. 
  • To prep for a colonoscopy, you’ll go on a liquid diet and take medication to help clear out your colon. This helps your doctor have a clear view of your colon and rectum. 

Want to protect your colorectal health? Find a doctor at Weill Cornell Medicine to get started.