Steven M. Lipkin, MD, PhD

Clinical Genetics (MD)
Steven Lipkin


Dr. Lipkin is a board certified Medical Geneticist with a focus on genetic testing for adult and cancer genetic diseases, including the Lynch Syndrome, Familial Adenomatous Polyposis, and Hereditary Pancreatic Cancer among others. He is an authority on cancer and adult genetic syndromes, with a particular emphasis on hereditary Gastrointestinal cancer syndromes. He is the author of MAPP-MMR, a bioinformatic program that is used to interpret whether Lynch syndrome missense variants are deleterious muations or benign polymorphisms. He practices at Weill Medical College of Cornell University and New York-Presbyterian Hospital. He trained in Internal Medicince at Duke University and Medical Genetics at the National Human Genome Research Institute.


Insurance Plans Accepted

The following represents most of the managed care plans accepted by this physician. If your insurance carrier does not appear here please contact the physician’s office as they may have individual contracts not included on this site.

* indicates this physician is no longer accepting new patients with this insurance plan.

  • AETNA [Medicare]
  • Aetna - Weill Cornell [POS]
  • Blue Priority Network
  • Empire Blue Cross/Blue Shield [Pathway X]
  • Empire Blue Cross/Blue Shield [Pathway X Enhanced]
  • Empire Blue Cross/Blue Shield [PPO]
  • Empire Blue Cross/Blue Shield [Mediblue (Senior)]
  • Empire Blue Cross/Blue Shield [HMO]
  • Empire Blue Cross/Blue Shield [EPO]
  • Health Plus - Amerigroup [CHP]
  • Health Republic
  • Medicaid
  • Medicare
  • Oscar
  • Oxford Health Plans [Medicare Advantage]
  • Oxford Health Plans [Liberty]
  • Oxford Health Plans [Freedom]
  • Rockefeller University - CoreSource
  • UHC Compass
  • United Health Care [Medicare]
  • United Health Care






1.         Glass, C.K., Lipkin, S.M., Devary, O.V., and Rosenfeld, M.G. 1989. Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer. Cell 59:697-708.


2.         Lipkin, S.M. 1990. An occupational hazard. The Western Journal of Medicine 153:565-566.


3.         Naar, A.M., Boutin, J.M., Lipkin, S.M., Yu, V.C., Holloway, J.M., Glass, C.K., and Rosenfeld, M.G. 1991. The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors. Cell 65:1267-1279.


4.         Lipkin, S.M., Nelson, C.A., Glass, C.K., and Rosenfeld, M.G. 1992. A negative retinoic acid response element in the rat oxytocin promoter restricts transcriptional stimulation by heterologous transactivation domains. Proceedings of the National Academy of Sciences of the United States of America 89:1209-1213.


5.         Lipkin, S.M., Rosenfeld, M.G., and Glass, C.K. 1992. Regulation of gene expression by thyroid hormones and retinoic acid. Genetic Engineering 14:185-209.


6.         Lipkin, S.M., Naar, A.M., Kalla, K.A., Sack, R.A., and Rosenfeld, M.G. 1993. Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression. Genes & Development 7:1674-1687.


7.         Lipkin, S.M., Grider, T.L., Heyman, R.A., Glass, C.K., and Gage, F.H. 1996. Constitutive retinoid receptors expressed from adenovirus vectors that specifically activate chromosomal target genes required for differentiation of promyelocytic leukemia and teratocarcinoma cells. Journal of Virology 70:7182-7189.


8.         Lipkin, S.M., Wang, V., Jacoby, R., Banerjee-Basu, S., Baxevanis, A.D., Lynch, H.T., Elliott, R.M., and Collins, F.S. 2000. MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability. Nature Genetics 24:27-35.


9.         Lipkin, S.M., Wang, V., Stoler, D.L., Anderson, G.R., Kirsch, I., Hadley, D., Lynch, H.T., and Collins, F.S. 2001. Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: Evidence for somatic mutation in colorectal cancers. Human Mutation 17:389-396.


10.       Stella, A., Wagner, A., Shito, K., Lipkin, S.M., Watson, P., Guanti, G., Lynch, H.T., Fodde, R., and Liu, B. 2001. A nonsense mutation in MLH1 causes exon skipping in three unrelated HNPCC families. Cancer Research 61:7020-7024.


11.       Lipkin, S.M., Moens, P.B., Wang, V., Lenzi, M., Shanmugarajah, D., Gilgeous, A., Thomas, J., Cheng, J., Touchman, J.W., Green, E.D. and Lipkin SM. 2002. Meiotic arrest and aneuploidy in MLH3-deficient mice. Nature Genetics 31:385-390.


12.       Lynch, H.T., Weisenburger, D.D., Quinn-Laquer, B., Snyder, C.L., Lynch, J.F., Lipkin, S.M., and Sanger, W.G. 2002. Family with acute myelocytic leukemia, breast, ovarian, and gastrointestinal cancer. Cancer Genetics and Cytogenetics 137:8-14.


13.       Kudryavtseva, E.I., Sugihara, T.M., Wang, N., Lasso, R.J., Gudnason, J.F., Lipkin, S.M., and Andersen, B. 2003. Identification and characterization of Grainyhead-like epithelial transactivator (GET-1), a novel mammalian Grainyhead-like factor. Developmental Dynamics 226:604-617.


14.       Lipkin SM, Rozek LS, Rennert G, Yang W, Chen PC, Hacia J, Hunt N, Shin B, Fodor S, Kokoris M, Greenson JK, Fearon E, Lynch H, Collins F, Gruber SB. 2004. The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer. Nature Genetics 36(7): 694-9


15.       Cannavo, E., Marra, G., Sabates-Bellver, J., Menigatti, M., Lipkin, S.M., Fischer, F., Cejka, P., and Jiricny, J. 2005. Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair. Cancer Research 65:10759-10766.


16.       Chen, P.C., Dudley, S., Hagen, W., Dizon, D., Paxton, L., Reichow, D., Yoon, S.R., Yang, K., Arnheim, N., Liskay, R.M., and Lipkin SM. 2005. Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse. Cancer Research 65:8662-8670.


17.       Frank, S.A., Chen, P.C., and Lipkin, S.M. 2005. Kinetics of cancer: a method to test hypotheses of genetic causation. BMC Cancer 5:163.


18.       Kolas, N.K., Svetlanov, A., Lenzi, M.L., Macaluso, F.P., Lipkin, S.M., Liskay, R.M., Greally, J., Edelmann, W., and Cohen, P.E. 2005. Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I. Journal of Cell Biology 171:447-458.


19.       Rozek, L.S., Lipkin, S.M., Fearon, E.R., Hanash, S., Giordano, T.J., Greenson, J.K., Kuick, R., Misek, D.E., Taylor, J.M., Douglas, J.A., et al. 2005. CDX2 polymorphisms, RNA expression, and risk of colorectal cancer. Cancer Research 65:5488-5492.


20.       Shin, B.Y., Chen, H., Rozek, L.S., Paxton, L., Peel, D.J., Anton-Culver, H., Rennert, G., Mutch, D.G., Goodfellow, P.J., Gruber, S.B., and Lipkin SM. 2005. Low allele frequency of MLH1 D132H in American colorectal and endometrial cancer patients. Diseases of the Colon and Rectum 48:1723-1727.


21.       Chao, E.C., and Lipkin, S.M. 2006. Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis. Nucleic Acids Research 34:840-852.


22.       Wu, X., Tsai, C.Y., Patam, M.B., Zan, H., Chen, J.P., Lipkin, S.M., and Casali, P. 2006. A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation. Journal of Immunology 176:5426-5437.


23.       Zell, J.A., Rhee, J.M., Ziogas, A., Lipkin, S.M., and Anton-Culver, H. 2007. Race, socioeconomic status, treatment, and survival time among pancreatic cancer cases in California. Cancer Epidemiology, Biomarkers & Prevention 16:546-552.


24.       Chao, E.C., Velasquez, J.L., Witherspoon, M.S., Rozek, L.S., Peel, D., Ng, P., Gruber, S.B., Watson, P., Rennert, G., Anton-Culver, H., and Lipkin SM. 2008. Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR). Human Mutation 29:852-860.


25.       Chen, P.C., Kuraguchi, M., Velasquez, J., Wang, Y., Yang, K., Edwards, R., Gillen, D., Edelmann, W., Kucherlapati, R., and Lipkin, S.M.  Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression. PLoS Genetics 2008 4:e1000092.


26.       Le, H., Ziogas, A., Lipkin, S.M., and Zell, J.A. 2008. Effects of socioeconomic status and treatment disparities in colorectal cancer survival. Cancer Epidemiology, Biomarkers & Prevention 17:1950-1962.


27.       Le, H., Ziogas, A., Rhee, J.M., Lee, J.G., Lipkin, S.M., and Zell, J.A. 2008. A population-based, descriptive analysis of malignant intraductal papillary mucinous neoplasms of the pancreas. Cancer Epidemiology, Biomarkers & Prevention 17:2737-2741.


28.       Pan, Z., Sikandar, S., Witherspoon, M., Dizon, D., Nguyen, T., Benirschke, K., Wiley, C., Vrana, P., and Lipkin, S.M. 2008. Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice. Developmental Dynamics 237:316-327.


29.       Edwards, R.A., Witherspoon, M., Wang, K., Afrasiabi, K., Pham, T., Birnbaumer, L., and Lipkin, S.M. 2009. Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. Cancer Research 69:6423-6429.


30.       Le, H., Ziogas, A., Taylor, T.H., Lipkin, S.M., and Zell, J.A. 2009. Survival of distinct Asian groups among colorectal cancer cases in California. Cancer 115:259-270.


31.       Herbert, B.S., Chanoux, R.A., Liu, Y., Baenziger, P.H., Goswami, C.P., McClintick, J.N., Edenberg, H.J., Pennington, R.E., Lipkin, S.M., and Kopelovich, L. 2010. A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers. Oncotarget 1:405-422.


32.       Lipkin, S.M., Chao, E.C., Moreno, V., Rozek, L.S., Rennert, H., Pinchev, M., Dizon, D., Rennert, G., Kopelovich, L., and Gruber, S.B. 2010. Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer. Cancer Prevention Research 3:597-603.


33.       Sikandar, S., Dizon, D., Shen, X., Li, Z., Besterman, J., and Lipkin, S.M. 2010. The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical Wnt signaling. Oncotarget 1:596-605.


34.       Sikandar, S.S., Pate, K.T., Anderson, S., Dizon, D., Edwards, R.A., Waterman, M.L., and Lipkin, S.M. 2010. NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Research 70:1469-1478.


35.       Zhao, F., Edwards, R., Dizon, D., Afrasiabi, K., Mastroianni, J.R., Geyfman, M., Ouellette, A.J., Andersen, B., and Lipkin, S.M. 2010. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Developmental Biology 338:270-279.


36.       Shin, Y.J., Hencey, B., Lipkin, S.M., and Shen, X. 2011. Frequency domain analysis reveals external periodic fluctuations can generate sustained p53 oscillation. PloS One 6:e22852.


37.       Benoit, Y.D., Laursen, K.B., Witherspoon, M.S., Lipkin, S.M., and Gudas, L.J.  Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells. J Cell Physiol 2013 Apr 228(4): 764-72.


38.       Chen, H.J., Edwards, R., Tucci, S., Bu, P., Milsom, J., Lee, S., Edelmann, W., Gumus, Z.H., Shen, X., and Lipkin, S. 2012. Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis. Journal of Clinical Investigation 122:3184-3196. A Commentary on this paper was featured in the BioCentury journal SciBX 5:32 (2012). It also resulted in a patent filed by WCMC that is in process of being licensed.


39.       Crous-Bou, M., Rennert, G., Salazar, R., Rodriguez-Moranta, F., Rennert, H.S., Lejbkowicz, F., Kopelovich, L., Lipkin, S.M., Gruber, S.B., and Moreno, V. 2012. Genetic polymorphisms in fatty acid metabolism genes and colorectal cancer. Mutagenesis 27:169-176.


40.       Jahid, S., Sun, J., Edwards, R.A., Dizon, D., Panarelli, N.C., Milsom, J.W., Sikandar, S.S., Gumus, Z.H., and Lipkin, S.M. 2012. miR-23a promotes the transition from indolent to invasive colorectal cancer. Cancer Discovery 2:540-553.  


41.       Stadler ZK, Esposito D, Shah S, Vijai J, Yamrom B, Levy D, Lee YH, Kendall J, Leotta A, Ronemus M, Hansen N, Sarrel K, Rau-Murthy R, Schrader K, Kauff N, Klein RJ, Lipkin SM, Murali R, Robson M, Sheinfeld J, Feldman D, Bosl G, Norton L, Wigler M, Offit K. 2012. Rare de novo germline copy-number variation in testicular cancer. American Journal of Human Genetics 91:379-383.


42.       Verma, S., Salmans, M.L., Geyfman, M., Wang, H., Yu, Z., Lu, Z., Zhao, F., Lipkin, S.M., and Andersen, B. 2012. The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development. Developmental Biology 369:249-260.



43.       Wang, X., Wei, X., Thijssen, B., Das, J., Lipkin, S.M., and Yu, H. 2012. Three-dimensional reconstruction of protein networks provides insight into human genetic disease. Nature Biotechnology 30:159-164. The journal Nature published a “Technology Feature” commentary that highlighted this paper. Additionally, the journal Nature Methods dedicated its Systems Biology commentary section in “Research Highlights” to solely feature this paper.

44.       Vijai, J., Kirchhoff, T., Schrader, K.A., Brown, J., Dutra-Clarke, A.V., Manschreck, C., Hansen, N., Rau-Murthy, R., Sarrel, K., Przybylo, J., Shah, S., Cheguri, S., Stadler, Z., Zhang, L., Paltiel, O., Ben-Yehuda, D., Viale, A., Portlock, C., Straus, D., Lipkin, SM, Lacher, M., Robson, M., Klein, R.J., Zelenetz, A. & Offit, K. Susceptibility Loci associated with specific and shared subtypes of lymphoid malignancies. PLoS Genetics 2013 9(1):e1003220 (2013).  


45.       Bu, P., Chen, K., Chen, J., Wang, L., Walters, J., Shin, Y., Goerger, J, Sun, J., Witherspoon, M., Rakhilin, N., Li, J., Yang, H., Milsom, J., Lee, S., Zipfel, W., Jin, M., Gümüş, G., Lipkin*, S., and Shen, X. A microRNA miR-34a Regulated Bimodal Switch targets Notch in Colon Cancer Stem Cells. Cell Stem Cell 2013 May 2;12(5):602-15 (*Co-corresponding author). The journal Cell Stem Cell published a Preview describing this work in the same issue on pages 499-500.


46.       Guo Y, Wei X, Das J, Grimson A, Lipkin SM, Clark AG, Yu H. Dissecting Disease Inheritance Modes in a Three-Dimensional Protein Network Challenges the "Guilt-by-Association" Principle. American Journal of Human Genetics. 2013 Jul 11;93(1):78-89


47.       Das J, Vo TV, Wei X, Mellor JC, Tong V, Degatano AG, Wang X, Wang L, Cordero NA, Kruer-Zerhusen N, Matsuyama A, Pleiss JA, Lipkin SM, Yoshida M, Roth FP, Yu H. Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.  Science Signaling. 2013 May 21;6(276):ra38.   


48.       Witherspoon M, Chen Q, Kopelovich L, Gross SS, Lipkin SM. Unbiased metabolite profiling indicates that a diminished thymidine pools is the underlying mechanism of colon cancer chemoprevention by alpha-difluoro-methylornithine (DFMO).Cancer Discovery 2013 Sep;3 (9):1072-81. A Commentary in the same issue of the journal highlighted this work.


49.       Vijai J, Kirchhoff T, Schrader KA, Brown J, Dutra-Clarke AV, Manschreck C, Hansen N, Rau-Murthy R, Sarrel K, Przybylo J, Shah S, Cheguri S, Stadler Z, Zhang L, Paltiel O, Ben-Yehuda D, Viale A, Portlock C, Straus D, Lipkin SM, Lacher M, Robson M, Klein RJ, Zelenetz A, Offit. Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. PLoS Genet. 2013;9(1):e1003220.


50.       Ekta Khurana, Yao Fu, Vincenza Colonna, Xinmeng Jasmine Mu, Hyun Min Kang, Tuuli Lappalainen, Andrea Sboner, Lucas Lochovsky, Jieming Chen, Arif Harmanci, Jishnu Das, Alexej Abyzov, Suganthi Balasubramanian, Kathryn Beal, Dimple Chakravarty, Daniel Challis, Yuan Chen, Declan Clarke, Laura Clarke, Fiona Cunningham, Uday S. Evani, Paul Flicek, Robert Fragoza, Erik Garrison, Richard Gibbs, Zeynep H. Gümüş, Javier Herrero, Naoki Kitabayashi, Yong Kong, Kasper Lage, Vaja Liluashvili, Steven Lipkin, Daniel G. MacArthur, Gabor Marth, Donna Muzny, Tune H. Pers, Graham R. S. Ritchie, Jeffrey A. Rosenfeld, Cristina Sisu, Xiaomu Wei, Michael Wilson, Yali Xue, Fuli Yu, 1000 Genomes Project Consortium, Emmanouil T. Dermitzakis, Haiyuan Yu, Mark A. Rubin, Chris Tyler-Smith and Mark Gerstein “Integrative annotation of variants from 1,092 humans: application to cancer genomics” Science. 2013 Oct 4;342(6154):1235587.


51.       Marta Crous-Bou, Gad Rennert, Daniel Cuadras, Ramon Salazar, David Cordero, Hedy Saltz Rennert, Flavio Lejbkowicz, Levy Kopelovich, Steven M Lipkin, Stephen B Gruber and Victor Moreno. Polymorphisms in alcohol metabolism genes ADH1B and ALDH2, alcohol consumption and colorectal cancer PloSOne 2013 Nov 25;8(11):e80158.

52.       Schrader KA, Stratton KL, Murali R, Laitman Y, Cavallone L, Offit L, Wen YH, Thomas T, Shah S, Rau-Murthy R, Manschreck C, Salo-Mullen E, Otegbeye E, Corines M, Zhang L, Norton L, Hudis C, Klein RJ, Kauff ND, Robson M, Stadler ZK, Haber DA, Lipkin SM, Friedman E, Foulkes WD, Altshuler D, Vijai J, Offit K. Genome Sequencing of Multiple Primary Tumors Reveals a Novel PALB2 Variant. J Clin Oncol. 2014 Jun 30   JCO.2013.50.0272.

53.      Xiaomu Wei, Jishnu Das, Robert Fragoza, Jin Liang, Francisco M. Bastos de Oliveira, Hao Ran Lee, Xiujuan Wang, Matthew Mort, Peter D. Stenson, David N. Cooper, Steven M. Lipkin, Marcus B. Smolka, Haiyuan Yu. A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations. PloS Genetics 2014 Dec 11;10(12):e1004819.


54.       Gillen, DG, Meyskens, FL, Morgan, TM, Zell, J, Carroll, R., Benya, R.,Chen, WP,Mo, A., Tucker,C., Bhattacharya, A.,Huang, Z.,Arcilla, M.,Wong, V.,Chung,V., Gonzalez,R., Rodriguez,L., Szabo, E., Rosenberg, D and Lipkin, SM. A Phase IIa Randomized, Double-Blind Trial of Erlotinib in Inhibiting EGF Receptor Signaling in Aberrant Crypt Foci of the Colorectum. Cancer Prevention Research 2015 Mar;8(3):222-30

55.       Bu, P., Wang, L., Chen, K., Rakhilin, N., Sun, J., Closa, A., Tung, K., King, S., Varanko, A., Xu, Y., Chen, J., Zessin, A., Shealy, J., Cummings, B., Hsu, D., Lipkin, SM, Moreno, V., Gümüş, Z., and Shen, X. miR-1269 Promotes Metastasis and Forms a .Positive Feedback Loop with TGF-Beta. Nature Communications (in press).

56.       Chen, H., Sun, J., Huang, Z., Hou, H., Arcilla, M, Rakhilin, N., Joe, D., Choi, J., Gadamsetty, P., Milsom, J., Nandakumar, G., Longman, R., Zhou, K., Edwards, R., Chen, J., Chen, K., Bu, P. Miller, A., Gümüş, Z., Shuler, M., Nishimura, N., Edelmann, W., Shen, X., Lipkin, SM. Chemokine-Targeted Mouse Models of Human Primary and Metastatic Colorectal Cancer. Nature Biotechnology 2015 (In press).

57.       Goodenberger ML, Thomas BC, Riegert-Johnson D, Boland CR, Plon SE, Clendenning M, Win AK, Senter L, Lipkin SM, Stadler ZK, Macrae FA, Lynch HT, Weitzel JN, de la Chapelle A, Syngal S, Lynch P, Parry S, Jenkins MA, Gallinger S, Holter S, Aronson M, Newcomb PA, Burnett T, Le Marchand L, Pichurin P, Hampel H, Terdiman JP, Lu KH, Thibodeau S, Lindor NM. PMS2 monoallelic mutation carriers: the known unknown. Genet Med. 2015 Apr 9

Honors and Awards

2015-Fellow, American Society of Clinical Investigation (ASCI)
2013 Adjunct Professor of Medicine, School of Basic Medical Sciences, Beijing University
2005-Athalie Clark Junior Faculty Research Scholar Award

2005-2003 American Cancer Society Research Scholar

2000 Board Certification American College of Medical Genetics

1999 Board Certification, American Board of Internal Medicine

1995-1986 NIH Medical Scientist Training Program Fellowship   
1986 Summa cum laude, Princeton University


1986 Phi Beta Kappa, Princeton University