Peter Goldstein, M.D.

Peter Goldstein


Dr. Goldstein is a graduate of Cornell University, and he received his medical degree from the Mt. Sinai School of Medicine of the City University of New York. He completed a one-year internship in the Dept. of Surgery at the Mt. Sinai Hospital in New York, followed by a residency in Anesthesiology at the Columbia-Presbyterian Hospital in New York. Dr. Goldstein received an additional two years of training in the Dept. of Physiology and Biophysics at the College of Physicians and Surgeons of Columbia University as a Post-Doctoral Trainee through the United States Public Health Service. Dr. Goldstein was an Assistant Attending in Anesthesiology at the Columbia Presbyterian Medical Center before joining the Department of Anesthesiology at the Weill Cornell Medical Center in 2000.

Dr. Goldstein is a Principal Investigator in the C.V. Starr Laboratory for Molecular Neuropharmacology in the Department of Anesthesiology at the Weill Cornell Medical College, and his laboratory is primarily interested in thalamic physiology and the molecular and cellular mechanisms of anesthetic-induced unconsciousness. He has authored numerous publications and serves on various state and national committees related to the practice of anesthesiology. His clinical practice focuses on anesthesia for neurosurgery and bariatric procedures.

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Insurance Plans Accepted

The following represents most of the managed care plans accepted by this physician. If your insurance carrier does not appear here please contact the physician’s office as they may have individual contracts not included on this site.

* indicates this physician is no longer accepting new patients with this insurance plan.

  • AETNA [Medicare]
  • Aetna - Weill Cornell [POS]
  • Affinity Essential
  • Affinity Health Plan
  • Blue Priority Network
  • Emblem Select Care
  • Empire Blue Cross/Blue Shield [EPO]
  • Empire Blue Cross/Blue Shield [Pathway X Enhanced]
  • Empire Blue Cross/Blue Shield [PPO]
  • Empire Blue Cross/Blue Shield [Pathway X]
  • Empire Blue Cross/Blue Shield [HMO]
  • Empire Blue Cross/Blue Shield [Mediblue (Senior)]
  • GHI [CBP]
  • Health First
  • Health Insurance Plan of NY (HIP) [Medicare]
  • Health Insurance Plan of NY (HIP) [Medicaid]
  • Health Insurance Plan of NY (HIP)
  • Health Plus - Amerigroup [CHP]
  • Health Plus - Amerigroup
  • Health Republic
  • Medicaid
  • Medicare
  • Oscar
  • Oxford Health Plans [Liberty]
  • Oxford Health Plans [Medicare Advantage]
  • Oxford Health Plans [Freedom]
  • Rockefeller University - CoreSource
  • UHC Compass
  • United Empire
  • United Health Care
  • United Health Care [Medicare]
  • United Health Care [Community Plan]
  • VNSNY CHOICE Medicare [Medicare]
  • VNSNY CHOICE Medicare [HMO]


Peer Reviewed

35) Calder E, Tchieu J, Steinbeck JA, Tu E, Keros S, Ying SW, Jaiswal MK, Cornacchia D, Goldstein PA, Tabar V & Studer L (2015). Retinoic Acid-mediated regulation of GLI3 enables efficient motoneuron derivation from human ESCs in the absence of extrinsic SHH activation. J Neurosci, 35(33):11462-11481.

34) Jaiswal MK, Keros S, Zhao M, Inan M, Schwartz TH, Anderson SA, Homanics GE & Goldstein PA (2015). Seizure-reduction following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit. Front Cell Neurosci, 9:127. DOI: 10.3389/fncel.2015.00127, Epub date 2015/03/18.

33) Mattusch C, Kratzer S, Buerge  M, Kreuzer M, Engel T, Biel M, Ying SW, Goldstein PA, Kochs E, Haseneder R & Rammes G (2015). Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments. Anesthesiology, 122:1047-59. Highlighted paper.

32) Li J & Goldstein PA (2015). Cranial settling - A complication of rheumatoid arthritis. Anesthesiology, 123(3):668. PMID:25415824.

31) Goldstein PA, Storey-Johnson C & Beck S (2014). Facilitating the initiation of the physician's professional identity - Cornell's Urban Semester Program. Persp Med Educ, 3(6):492-9.

30) Lyashchenko AK, Redd KJ, Goldstein PA & Tibbs GR (2014). cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.  PLoS One, 9(7):e101236.

29) Maroof AM, Keros S, Tyson JA, Ying SW, Ganat YM, Merkle FT, Liu R, Goulburn A, Stanley EG, Elafanty AG, Widmer HR, Eggan K, Goldstein PA, Anderson SA & Studer L (2013). Directed differentiation of human pluripotent stem cells into cortical interneurons. Cell Stem Cell, 12:559-572.

28) Tibbs GR, Rowley TJ, Sanford RL, Herold KF, Proekt A, Hemmings HC, Andersen OS, Goldstein PA* & Flood PD (2013). HCN1 channels as targets for anesthetic and non-anesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain. J Pharm Exp Ther, 345:363-373. *Corresponding author.  Highlighted Paper.

27) Lafaille FG, Pessach IM, Zhang SY, Ciancanelli MJ, Herman M, Abhyankar A, Ying SW, Keros S, Goldstein PA, Mostoslavsky G, Ordovas-Montanes J, Jouanguy E, Tu E, Elkabetz Y, Al-Muhsen S, Tardieu M, Schlaeger TM, Daley GQ, Abel L, Casanova JL, Studer L, Notarangelo LD (2012). Impaired intrinsic IFN-α/β immunity to HSV-1 in human iPSC-derived UNC-93B- and TLR3-deficient central nervous system cells. Nature, 491:769-774.

26) Ying SW, Kanda VA, Hu Z, Purtell K, King EC, Abbott GW & Goldstein PA (2012). Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits. PLoS One, 7(8): e42756. doi:10.1371/journal.pone.0042756.

25) Ying SW, Tibbs GR, Picollo A, Abbas SY, Sanford RL, Accardi A, Hofmann F, Ludwig A & Goldstein PA (2011). PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons. J Neurosci, 31:10412-10423.

24) Jia F, Goldstein PA & Harrison NL (2009). The modulation of synaptic GABAA receptors in the thalamus by eszopiclone and zolpidem. J Pharm Exp Ther, 328:1000-1006.

23) Ying SW, Warner D, Homanics GE, Harrison NL & Goldstein PA (2009). Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms. Neuropharmacology, 56:438-447.

22) Roepke TK, Kontogeorgis A, Xu X, Young JB, Purtell K, Ovanez C, Akar F, Goldstein PA, Christini DJ, Peters NS, Gutstein DE, Lerner DJ & Abbott GW (2008). kcne2 disruption impairs ventricular repolarization via disruption of IK,slow1 and Ito,f. FASEB J, 22:3648-3660.

21) Jia F, Yue M, Chandra D, Homanics GE, Goldstein PA, Harrison NL (2008). Isoflurane is a potent modulator of extrasynaptic GABAA receptors in the thalamus. J Pharm Exp Ther, 324:1127-1135.

20) Jia F, Yue M, Chandra D, Goldstein PA, Homanics GE, Harrison NL (2008). Taurine is a potent activator of extrasynaptic GABAA receptors in the thalamus. J Neuroscience, 28:106-115.

19) Ying SW, Jia F, Abbas SY, Hofmann F, Ludwig A & Goldstein PA (2007). Dendritic HCN2 channels constrain glutamate-driven excitability in reticular thalamic neurons. J Neuroscience, 27:8719-8732.

18) Naguib M, Gottumkkala V & Goldstein PA (2007). Melatonin and anesthesia: A clinical perspective. J Pineal Res, 42:12-21.

17) Abbas S, Ying SW & Goldstein PA (2006). Compartmental distribution of HCN2 and HCN4 channels in thalamic reticular and thalamocortical relay neurons. Neuroscience, 141:1811-1825.

16) Ying SW, Abbas S, Harrison NL & Goldstein PA (2006). Propofol block of Ih contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons. Eur J Neurosci, 23:465-480.

15) Jia F, Pignataro L, Schofield CM, Yue M, Harrison NL & Goldstein PA (2005). An extrasynaptic GABAA receptor mediates tonic inhibition in thalamocortical relay neurons. J Neurophysiology, 94:4491-4501.

14) Hemmings HC, Akabas MH, Goldstein PA, Trudell JR, Orser BA & Harrison NL (2005). Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci, 26(10):503-510.

13) Cacheaux L, Topf N, Tibbs G, Schaefer U, Levi R, Harrison NL, Abbott G & Goldstein PA (2005). Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol. J Pharm Exp Ther, 315:517-525.

12) Ying SW & Goldstein PA (2005). Propofol suppresses synaptic responsiveness of thalamic somatosensory relay neurons to exctitatory input by potentiating GABAA receptor chloride channels. Molec Pain, online publication date January 14, 2005, doi:10.1186/1744-8069-1-2.

11) Ying SW & Goldstein PA (2005). Propofol-block of SK channels in reticular thalamic neurons enhances GABAergic inhibition in relay neurons. J Neurophysiology 93(4):1935-1948.

10) Homanics GE, Elsen FP, Jenkins A, Ferguson C, Sloat B, Yuditskaya S, Ying SW, Goldstein PA, Kralic J, Morrow AL & Harrison NL (2005). A gain of function mutation in the GABAA receptor produces synaptic and behavioral abnormalities in the mouse. Genes Brain Behavior, 4:10-19.

9) Pryor KO, Fahey TJ, III, Lien CA & Goldstein PA (2004). Surgical site infection and the routine use of perioperative hyperoxia in a general surgical population: a randomized controlled trial. JAMA 291, 79-87.

8) Goldstein PA, Elsen FP, Ying SW, Ferguson C, Homanics GE & Harrison NL (2002). Prolongation of hippocampal miniature inhibitory postsynaptic currents in mice lacking the GABAA receptor α1 subunit. J Neurophysiology 88:3208-17.

7) Okamoto M, Baba H, Goldstein PA, Higashi H, Shimoji K & Yoshimura M. (2001). Functional reorganization of sensory pathways in the rat spinal dorsal horn following peripheral nerve injury. J Physiol (Lond) 532.1:241-250.

6) Baba H, Goldstein PA, Okamoto M, Kohno T, Ataka T, Yoshimura M & Shimoji K (2000). Norepinephrine facilitates inhibitory transmission in substantia gelatinosa of adult rat spinal cord (Part 2): Effects on somatodendritic sites of GABAergic neurons. Anesthesiology 92:485-492.

5) Baba H, Kohno T, Okamoto M, Goldstein PA, Shimoji K & Yoshimura M (1998). Muscarinic facilitation of GABA release in substantia gelatinosa of rat spinal dorsal horn. J Physiol (Lond) 508.1:83-93.

4) Bardoni R, Goldstein PA, Lee CJ, Gu J & MacDermott AB (1997). ATP-receptor mediated synaptic transmission in the dorsal horn of the rat spinal cord. J Neuroscience 17:5297-5304.

3) Kyrozis A, Goldstein PA, Heath MJS & MacDermott AB (1995). Calcium entry through a subpopulation of AMPA receptors evokes desensitization of closely co-localized NMDA receptors. J Physiol (Lond) 485.2:373-381.

2) Goldstein PA, Lee CJ & MacDermott AB (1995). Variable distributions of Ca2+ -permeable and Ca2+ -impermeable AMPA receptors on embryonic rat dorsal horn neurons. J Neurophysiology 73:2522-2534.

1)   Goldstein P, Berrier J, Rosenberg S, Sacks HS & Chalmers TC (1989). A meta-analysis of randomized control trials of progestational agents in pregnancy. Br J Obstet Gynaecol 96:265-274.


2)   Goldstein PA (2015). HCN1 channels as targets for volatile anesthetics; coming to the fore. Anesth Analgesia, 121(3):594-596 (invited editorial)

1)     Naguib M & Goldstein PA (2009). All results count. Anesth Analgesia, 108:1058-1061. (invited editorial)





Honors and Awards

1987   Mt. Sinai School of Medicine Research Award

1993   Recipient, Foundation for Anesthesia Education & Research Starter Grant

1997   Recipient, NIH Mentored Clinical-Scientist Development Grant (KO8)

2004   NIH RO1 Grant - Anesthetic effects on thalamic synaptic transmission

2005   Elected Member, Association of University Anesthesiologists

2014   Recipient, Daedalus Fund for Innovation Award, Weill Cornell Medical College

2015   Recipient, US Dept. of Defense Grant - Novel non-anesthetic alkylphenols for the treatment of                 neuropathic pain