Language: English
Gender: Male
Cardiothoracic Surgery
525 East 68th Street, M-404
New York, NY 10065
P: (212) 746-5151 | F: 646-962-0108
Call for appointment
(212) 746-5151

Personal Statement

Ours is truly an outstanding staff. The physicians, anesthesiologists, cardiologists, nurses and administrative staff are some of the most capable people in the country, and they are right here at Weill Cornell Medical Center. The quality of our care is the result of a team effort. I am not only speaking of the surgical team, I mean everyone--from the doctors to the people who clean the operating rooms. Being the best means taking pride in what you do, caring a little more and going a little further--everyone here does, and its evidence is in our results.



  Rated One of New York Magazine's Best Doctors.


One of America's Top Doctors.

View Biography


Board Certifications
  • Surgery
  • Surgery, Thoracic
  • Cardiothoracic Surgery
  • Surgery, Thoracic Cardiovascular
  • Heart Surgery
  • Cardiac Surgery
  • Congenital Heart Disease
  • Coronary Artery Bypass Surgery
  • Heart Failure
  • Cardiac Valve Surgery
  • Heart Valve Repair
  • Minimally Invasive Adult Cardiothoracic Surgery
  • Off Pump Coronary Bypass Surgery
  • Adult Congenital Heart Disease
  • Thoracic Aneurysms and Dissections
  • Mitral Valve Repair
  • Minimally Invasive Cardiac Surgery
  • Mitral/Aortic Valve Replacement
  • Mitral Valve Prolapse
  • Aortic Valve Surgery
  • Mitral Valve Surgery
  • Aortic and Mitral Valve Surgery
  • Cardiac Valve Replacement
  • Bicuspid Aortic Valve
  • Bloodless Surgery
  • Thoracic/Cardiothoracic Surgery
  • Coronary Artery Bypass
  • Heart Valve Disease
  • Mitral Valve Reconstruction
  • Open Heart Surgery
  • Heart Valve Surgery
  • Valve Reconstruction/Repair
  • Valve Replacement
  • Minimally Invasive Valve Repair
  • Heart Valve Replacement

Insurance Plans Accepted

The following represents most of the managed care plans accepted by this physician. If your insurance carrier does not appear here please contact the physician’s office as they may have individual contracts not included on this site.

* indicates this physician is no longer accepting new patients with this insurance plan.

  • AETNA [Medicare]
  • Aetna - Weill Cornell [POS]
  • Affinity Essential
  • Affinity Health Plan
  • Blue Priority Network
  • Emblem Select Care
  • Empire Blue Cross/Blue Shield [EPO]
  • Empire Blue Cross/Blue Shield [Pathway X Enhanced]
  • Empire Blue Cross/Blue Shield [PPO]
  • Empire Blue Cross/Blue Shield [Pathway X]
  • Empire Blue Cross/Blue Shield [HMO]
  • Empire Blue Cross/Blue Shield [Mediblue (Senior)]
  • Fidelis Care
  • Health First
  • Health Insurance Plan of NY (HIP) [Medicare]
  • Health Insurance Plan of NY (HIP)
  • Health Insurance Plan of NY (HIP) [Medicaid]
  • Health Plus - Amerigroup [CHP]
  • Health Plus - Amerigroup
  • Health Republic
  • Medicaid
  • Medicare
  • Oscar
  • Oxford Health Plans [Medicare Advantage]
  • Oxford Health Plans [Freedom]
  • Oxford Health Plans [Liberty]
  • Rockefeller University - CoreSource
  • UHC Compass
  • United Health Care [Medicare]
  • United Health Care [Community Plan]
  • United Health Care


  • M.D., University of Texas Southwestern Medical School, 1965

Honors and Awards

Texas Tech University, Distinguished Alumnus Award 1996

Cornell Medical College Third Year Teaching Award, Class of 1996

Helen Keller Services for the Blind Achievement Award, Contributions in the Medical Sciences, April 1997

Phi Gamma Delta Outstanding Alumnus Award, Texas Tech University, October 1998

Scientific Guest Speaker, Texas Surgical Society, October 1999

National Marfan Foundation, Hero with a Heart Award, December 2000

For Achievement in Cardiovascular Science and Medicine, Bugher Foundation Award, February 8, 2000

2001 Humanitarian Award, NYSAE Education and Research Foundation and Larry King Cardiac Foundation,

Distinguished Alumnus Lecture, Parkland Surgical Society, June 2003

Maurice R. Greenberg Distinguished Service Award, April 2004

Second Annual Covenant Heart Institute Michael E. DeBakey, MD, Distinguished Lecturer March 2005

Distinguished Service Award 2007, American Heart Association 11th Annual Heart of the Hamptons Gala

Castle Connolly 2011, National Physician of the Year Award for Clinical Excellence

Castle Connolly Medical Ltd. 2001 - 2011, America's Top Doctors

National Ethnic Coalition of Organizations 2011 2011, Ellis Island Medal of Honor Award

American Heart Association June 2012, One of 20 Champions of Heart & Stroke



Professor of Cardiothoracic Surgery
Weill Cornell Medical College

The Terry Allen Kramer Professor of Cardiothoracic Surgery
Weill Cornell Medical College

Dr. O. Wayne Isom is the Terry Allen Kramer Professor of Cardiothoracic Surgery at New York Presbyterian-Weill Cornell Medical Center.

Following his undergraduate studies at Texas Tech, Dr. Isom earned his medical degree at the University of Texas Southwestern Medical School in 1965. He then went on to finish a medical internship and general surgery residency at Parkland Hospital in Dallas; in 1970, he completed a cardiothoracic residency at New York University Medical Center. Dr. Isom joined the faculty at NYU School of Medicine, and, in 1978, he became Professor of Surgery and Director of the Cardiothoracic Training Program, a position he held for the next seven years.

In 1985, Dr. Isom was recruited to the New York-Cornell Medical Center (before The New York Hospital and Presbyterian Hospital merged to become New York Presbyterian Hospital) and assumed the Chairmanship of the Department of Cardiothoracic Surgery. Under his supervision, the Cardiothoracic surgeons at New York Presbyterian-Weill Cornell Medical Center have performed over 40,000 open-heart procedures, with results ranking the center as one of the best in the country.

Over his 50-year career, Dr. Isom has been responsible for teaching third year medical students, as well as general surgery house staff. He has also been instrumental in training over 80 cardiothoracic surgeons who are now either practicing or teaching throughout the country. The medical students at New York Presbyterian-Weill Cornell Medical Center have honored Dr. Isom in the past with the Cornell Medical College Third Year Teaching Award.

Dr. Isom is a member of numerous medical and surgical societies, including the American Association for Thoracic Surgery and the American College of Surgeons. He has been a Board Member of the American Heart Association in New York City for many years and in June 2012 named him "One of the 20 Champions of Heart & Stroke".  Most recently Texas Tech University honored him with an Honorary Doctor of Science degree.

Dr. Isom is the father of five children and currently resides in Manhattan with his wife, Pat.

Dr. Isom performed David Letterman's quintuple bypass surgery.