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Advances in Managing Mismatch Repair-Deficient Colon Cancer and Lynch Syndrome

colon
Mismatch repair-deficient (dMMR) colon cancer, also known as microsatellite instability-high (MSI-H), is a biologically distinct form of colorectal cancer caused by mutations in some of the genes that are involved in correcting mistakes made when DNA is copied in a cell. This type of colon cancer is highly responsive to treatment with immunotherapy, which has reshaped how clinicians’ approach care, leading to major advances across both early-stage and metastatic disease.

Sarah Silverman

Sarah Pauline Silverman, M.D.

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About Sarah Pauline Silverman, M.D.

Research

External Relationships

Relationships and collaborations with for-profit and not-for profit organizations are of vital importance to our faculty because these exchanges of scientific information foster innovation. As experts in their fields, WCM physicians and scientists are sought after by many organizations to consult and educate. WCM and its faculty make this information available to the public, thus creating a transparent environment.

No External Relationships Reported

Liquid Biopsies: A New Way to Learn About Cancer From a Blood Sample

liquid biopsies
Liquid biopsies are changing how doctors learn about cancer. Instead of taking a tissue sample from a tumor, a liquid biopsy uses a simple blood draw to gather clues about what’s happening inside the body.

Is it the Winter Blahs or Seasonal Affective Disorder (SAD)?

Girl sits on the window sill of the window and looks at the falling snow. The concept of home comfort, season, solitude
SAD is a type of depression that often occurs during the late fall and throughout the winter months. The disorder goes beyond the usual blahs. Women and residents of northeastern states are at higher risk of developing symptoms than those living in other parts of the country.

Vodcast: Radiofrequency Ablation (RFA)

Cardiologist use tubes and ultrasound for radiofrequency catheter ablation.
In this Back to Health episode, Dr. Philip Petrou discusses radiofrequency ablation (RFA), a cutting-edge treatment for chronic pain.

Advancing Health Equity Through Community-Centered Research

Medicine And Health Care Concept. Black female doctor in white coat holding digital tablet with empty screen for mockup, showing male patient his test results and discussing treatment, sitting at desk
In honor of Black History Month, Dr. Ro-Jay Reid from the Division of General Internal Medicine at Weill Cornell Medicine shared how his work is transforming our understanding of healthy aging, especially for communities historically impacted by health disparities. His commitment began with early experiences that showed how deeply social conditions shape longterm health.

Infographic: How to Eat With Your Heart in Mind

Happy family cooking together at home and smiling
Your heart works tirelessly for you every day. Support it by being mindful of not only what you eat, but also how you eat.

Shoveling Snow Can Be Hazardous to Your Cardiac Health

Elderly man cleaning snow with shovel after snowstorm, sunlight.
Dr. Senturia names some of the usual suspects—male gender, older age, a sedentary lifestyle and smoking—as reasons to avoid shoveling snow. Another strong cardiac risk factor is a family history of heart disease.

Mariano Siragusa

Mariano Siragusa, MSN, NP

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Locations and Appointments
Insurance
About
Insurances Accepted

For relevant information regarding accepted insurances, please contact this provider directly.

About Mariano Siragusa, MSN, NP

External Relationships

Relationships and collaborations with for-profit and not-for profit organizations are of vital importance to our faculty because these exchanges of scientific information foster innovation. As experts in their fields, WCM physicians and scientists are sought after by many organizations to consult and educate. WCM and its faculty make this information available to the public, thus creating a transparent environment.

No External Relationships Reported

Podcast: Biliary Atresia

Doctor and mother and child in a consultation room. Pediatrician.
In this episode of Kids Health Cast, Drs. Angela Kadenhe-Chiweshe and Adriana Perez discuss biliary atresia, a serious life-threatening liver disease that affects approximately one in 10,000 children.