Dr. Knoepflmacher attended Columbia University, where he graduated magna cum laude. After college, he completed an MFA in Film Production at the University of Southern California School of Cinematic Arts. He embarked on a successful career in the entertainment industry as an editor specializing in theatrical and television marketing campaigns for major studio films. After several years, Dr. Knoepflmacher left the entertainment business to begin medical training at Oregon Health and Sciences University in Portland, Oregon.  

While in medical school, he was honored as the top medical student in Psychiatry, inducted into the Gold Humanism Honor Society, and was chosen for the Leonard Tow Humanism in Medicine Award. Dr. Knoepflmacher completed his psychiatry residency at New York-Presbyterian/Weill Cornell Medical Center, where he was selected as chief resident, presented with the American Psychiatric Association Resident Recognition Award upon graduation, and was chosen as a fellow by the Group for the Advancement of Psychiatry.  

Dr. Knoepflmacher brings his unique background to his work as a psychiatrist, consultant, educator, and administrative leader. His past pursuits in a creative field and high-pressure business environments have informed his empathic approach to treating individuals struggling with personal, professional, academic, and artistic challenges. Additionally, he has worked as a consultant with leaders of external corporate and academic institutions to provide expert counsel on issues related to mental health and management of personnel. Dr. Knoepflmacher has contributed to multiple books, articles, and papers within the field of psychiatry and edited a video used nationwide to train psychiatry residents about substance use disorders. In addition to extensive clinical experience in multiple settings, he has supervised numerous residents on psychopharmacological and psychotherapeutic interventions. In 2020, he received an award for his dedicated teaching and outstanding mentorship in medical student education. He holds two key leadership roles within the Department of Psychiatry at Weill Cornell Medicine, as the Director of the General Psychiatry Residency Program and Vice Chair of Education.