Mark M. Souweidane, M.D.

Pediatric Neurological Surgery
Mark Souweidane

Mark M. Souweidane, MD has dedicated his career to the surgical treatment of children with brain and spinal disorders. His talents as a surgeon are paralleled by a caring attitude and time commitment to patients and their families. That the Weill Cornell Medical College is a recognized leader in Pediatric Neurosurgery is a direct result of his recruitment in 1995 and his ongoing devotion to contemporary surgical techniques and investigative endeavors. Specialized surgical skills have gained him international reputation for specific procedures, including removal of intraventricular brain tumors, management of pineal region tumors, treatment of congenital cysts, and surgery for Chiari malformation. In addition to the development of a world-class Pediatric Neurosurgery service, he has championed minimal access neurosurgery. His publications, clinical case volume, and practical courses continue to draw patients and practitioners that benefit from his endoscopic talents. His commitment to the education of future pediatric neurosurgeons is reflected in his participation on the Committee of Admissions for the medical college, his lectures to medical school students, his role as resident advisor, and resident mentoring at one of the country's premier training programs. Surgical areas of expertise include:

>> Removal of intraventricular brain tumors

>> Endoscopic intracranial surgery

>> Tumors (colloid cyst, benign astrocytoma)

>> Hydrocephalus (endoscopic third ventriculostomy)

>> Congenital cysts (endoscopic fenestration)

>> Treatment for Chiari malformations and syringomyelia

>> Management of pineal region tumors

>> Removal of intramedullary spinal cord tumors

>> Correction of craniofacial disorders

>> Multidisciplinary treatment of pediatric vascular abnormalities (arteriovenous malformations, Moyamoya disease, and cavernous malformations)

Dr. Souweidane currently serves as the Vice Chairman of the Department of Neurological Surgery and the Director of Pediatric Neurological Surgery at the Weill Cornell Medical College and Memorial Sloan-Kettering Cancer Center. He is an associate professor in Neurological Surgery and Pediatrics.


Dr. Souweidane sees patients at four offices:
Upper East Side: Starr
520 East 70th Street (east of York Avenue)
Starr Pavillion, Room 651
New York, NY

Upper East Side: Weill Greenberg
1305 York Avenue (at 70th Street)
Brain and Spine Center, 9th Floor
New York, NY

Lower Manhattan
156 William Street
11th Floor
New York, NY, 10038
Bayside Pediatric Specialty Care
26-19 Francis Lewis Blvd.
Bayside, NY 11358

Please confirm the location of your appointment with your patient coordinator.


Dr. Mark M. Souweidane completed his undergraduate training at the University of Michigan where he graduated with distinction in Microbiology. He attended Wayne State University Medical School as a member of the Alpha Omega Alpha Honor Society. His general surgery internship was completed at University of Michigan Hospitals and he subsequently did his neurosurgery residency at New York University under the direction of Drs. Joseph Ransohoff and Fred Epstein. He served as the chief clinical fellow for pediatric neurosurgery at the Hospital for Sick Children in Toronto during Harold Hoffman's tenure as chairman.

He has gained international acclaim in minimally invasive endoscopic neurosurgery for the treatment of hydrocephalus, intraventricular brain tumors, colloid cysts, and congenital cysts. His other areas of expertise include brain and spinal cord tumors of childhood, Chiari malformations, congenital spinal disorders, arachnoid cysts, and pediatric vascular disorders. His commitment to advanced surgical therapy for children with brain tumors is exemplified by his appointment as Chairman of the Neurosurgery Committee of the Children's Oncology Group. He is a member of the Professional Advisory Board of the Children's Brain Tumor Foundation. He has published 60 peer reviewed articles, authored 6 book chapters, and serves on the editorial board of the journal Neurosurgery. He is the principal investigator of a laboratory that is partly funded by the Pediatric Brain Tumor Foundation. His laboratory focuses on improving the outcome of children with brain tumors by studying experimental local delivery and brain tumor modeling.


Weill Cornell Pediatric Brain and Spine Center

Dr. Souweidane's Neuro-oncology Laboratory

Information for Parents

The Children's Brain Tumor Project

Perinatal Neurosurgery

Castle Connolly Top Doctors 2015 logo


Insurance Plans Accepted

The following represents most of the managed care plans accepted by this physician. If your insurance carrier does not appear here please contact the physician’s office as they may have individual contracts not included on this site.

* indicates this physician is no longer accepting new patients with this insurance plan.

  • Aetna - Weill Cornell [POS]
  • Affinity Essential
  • Affinity Health Plan
  • Blue Priority Network
  • Emblem Select Care
  • Empire Blue Cross/Blue Shield [Pathway X]
  • Empire Blue Cross/Blue Shield [PPO]
  • Empire Blue Cross/Blue Shield [Pathway X Enhanced]
  • Empire Blue Cross/Blue Shield [HMO]
  • Empire Blue Cross/Blue Shield [EPO]
  • Empire Blue Cross/Blue Shield [Mediblue (Senior)]
  • GHI [CBP]
  • Health First
  • Health Insurance Plan of NY (HIP) [Medicare]
  • Health Insurance Plan of NY (HIP)
  • Health Insurance Plan of NY (HIP) [Medicaid]
  • Health Plus - Amerigroup [CHP]
  • Health Plus - Amerigroup
  • Health Republic
  • Medicaid
  • Medicare
  • Oscar
  • Rockefeller University - CoreSource
  • United Health Care [Medicare]
  • United Health Care
  • United Health Care [Community Plan]
  • VNSNY CHOICE Medicare [HMO]


1.   Hoffman CE, Lis E, Wolden SL, Souweidane MM: Symptomatic Chiari Type I malformation after radiation therapy in an infant: case report. Neurosurgery 60:782, 2007


2.   Bassiri D, Luther N, Dunkel IJ, Edgar MA, Cheung NK, Wang QC, Pastan I, Gutin PH, Souweidane MM: Successful treatment of a human gliomas xenograft using the immunotoxin 8H9scFv-PE38 by interstitial infusion (abstr). Neuro-Oncology 8:425, 2006


3.   Souweidane MM, Dunkel IJ, Edgar MA, Manaqibwala M, Christos PJ, Becker L, Rutka JT: Intraoperative staging for posterior fossa brain tumors (abstr). Neuro-Oncology 8:463, 2006


4.   Souweidane MM, Luther N: Endoscopic resection of solid intraventricular brain tumors. J Neurosurg 105:271-278, 2006


5.   Otten ML, Riina HA, Gobin YP, Souweidane MM: Preoperative embolization in the treatment of choroid plexus papilloma in an infant. J Neurosurg (6 Suppl Pediatrics) 104:419-421, 2006


6.   Placantonakis DG, Lis E, Souweidane MM: Intradiploic cerebrospinal fluid fistulas of iatrogenic origin. Report of two cases: J Neurosurg (5 Suppl Pediatrics) 104:356-359, 2006


7.   Luther N, Edgar MA, Dunkel IJ, Souweidane MM: Correlation of endoscopic biopsy with tumor marker status in primary intracranial germ cell tumors. J Neuro-Oncl 79:45-50, 2006


8.   Greenfield JP, Souweidane MM: Endoscopic management of intracranial cysts. Neurosurg Focus 19(6):E7, 2005


9.   Souweidane MM: Advances in neurosurgical management of pineal sand suprasellar region primary CNS germ cell tumors (abstr). Neuro-Oncology 7(4):531, 2005


10.   Luther N, Dunkel IJ, Souweidane MM: Dissemination of intraventricular tumors following endoscopoic manipulation and third ventriculostomy. Neuro-Oncology 7(4):530, 2005


11.   Souweidane MM: Endoscopic surgery for intraventricular brain tumors in patients without hydrocephalus. Neurosurgery 57 (ONS Supp 3): 312-318, 2005


12.   Yoffe R, Khakoo Y, Dunekl IJ, Souweidane M, Lis E, Sklar C:Recurrent ependymoma treated with high-dose tamoxifen in a peripubertal female: Impact on tumor and the pituitary-ovarian axis. Pediatr Blood Cancer, Oct 31, 2005


13.   Arkin LM, Sondhi D, Worgall S, Suh LHK, Hackett NR, Kaminsky SM, Hosain SA, Souweidane MM, Kaplitt MG, Dyke JP, Heier LA, Ballon DJ, Shungu DC, Wisniewski KE, Greenwald BM, Hollmann C, Crystal RG: Confronting the Issues of Therapeutic Misconception, Enrollment Decisions, and Personal Motives in Genetic Medicine-Based Clinical Research Studies for Fatal Disorders. Hum Gene Therapy Sep 16 (9): 1028-1036, 2005


14.   Luther N, Cohen A, Souweidane MM: Hemorrhagic sequelae from intracranial neuroendoscopic procedures for intraventricular tumors. Neurosurg Focus 19 (1):E9, 2005


15.   Naraynaa A, Bhatia S, Souweidane M, Khakoo Y, Zaider M: (32)P radioisotope therapy for recurrent pilocytic astrocytomas. Brachytherapy 4:171-171, 2005


16.   Dunkel IJ, Souweidane MM: Brain Stem Tumors. Curr Treat Options in Neurology. 7:315-321, 2005


17.   Souweidane MM: Endoscopic management of pediatric brain tumors. Neurosurg Focus 18 (6a):E1, 2005


18.   Luther N, Souweidane MM: Neuroendoscopic resection of posterior third ventricular ependymoma. Neurosurg Focus 18 (6a):E3, 2005


19.   Placantonakis DG, Ney G, Edgar M, Souweidane M, Hosain S, Schwartz TH: Neurosurgical management of medically intractable epilepsy associated with hypomelanosis of Ito. Epilepsia 46:329-31, 2005


20.   Badie B, Brooks N, Souweidane MM: Endoscopic and minimally invasive microsurgical approaches for treating brain tumor patients. J Neuro-Oncology 69:209-219, 2004


21.   Souweidane MM, Occhiogrosso G, Mark EB, Edgar MA, Dunkel IJ: Interstitial infusion of carmustine in the rat brainstem with systemic administration of O6-benzylguanine. J Neuro-Oncl, 67:319-326, 2004


22.   Rutka JT, Souweidane MM, Brugge K, Armstrong D, Zuker R, Clarke H, Creighton R, McLeod E, Khoury A, Hoffman HJ: Separation of craniopagus twins in the era of modern neuroimaging, interventional neuroradiology, and frameless stereotaxy. Child’s Nerv Syst 20:587-592, 2004.


23.   Souweidane MM, Occhiogrosso G, Mark EB, Edgar MA. Interstitial Infusion of IL13-PE38QQR in the Rat Brain Stem. J Neuro-Oncl 67:287-293, 2004.


24.   Wang J, Souweidane MM: Advances in the endoscopic management of suprasellar arachnoid cysts in children. J Neurosurg: Pediatrics 100:418-426, 2004.


25.   Zonenshayn M, Kronberg E, Souweidane MM: Cranial index of symmetry: an objective semi-automated measure of plagiocephaly. J Neurosurg: Pediatrics 100:537-540, 2004.


26.   Sandberg DI, Bilsky MH, Kushner BH, Souweidane MM, Kramer K, Laquaglia MP, Panageas KS, Cheung NKV: Treatment of spinal involvement in neuroblastoma patients. Pediatr Neurosurg 39:291-298, 2003.


27.   Ulug AM, Truong TN, Filippi CG, Chun T, Lee JK, Yang C, Souweidane MM, Zimmerman RD. Diffusion imaging in obstructive hydrocephalus. AJNR 24:1171-1176, 2003.


28.   Wolden SL, Dunkel IJ, Souweidane MM, Happersett L, Khakoo Y, Schupak

K, Lyden D, Leibel SA. Patterns of failure using a conformal radiation

therapy tumor bed boost for medulloblastoma. J Clin Oncol 21:3079-3083, 2003.


29.   Souweidane MM, Occhigrosso G, Sandberg D, Edgar M. Convection-enhanced delivery into the rat brain stem: a potential delivery mechanism for the treatment of diffuse pontine gliomas. Neuro-Oncl 5:64, 2003.


30.   Dunkel I, Souweidane MM, Lyden D, Khakoo Y, Antunes N, Lis E, Wolden S. A pilot trial of reduced volume boost via intensity-modulated radiation therapy (IMRT) with craniospinal radiation therapy (RT) and chemotherapy for patients with newly diagnosed medulloblastoma. Neuro-Oncl 5:36, 2003.


31.   Occhiogrosso G, Edgar MA, Sandberg DI, Souweidane MM. Prolonged convection-enhanced delivery into the Rat Brain Stem. Neurosurgery 52:388-394, 2003.


32.   Antunes NL, Souweidane MM, Rosenblum MK, Steinhertz PG. Methotrexate leukoencephaly presenting as Kluver-Bucy syndrome and uncinate seizures. Pediatr Neurol 26:305-308, 2002.


33.   Antunes NL, Wolden S, Souweidane MM, Lis E, Rosenblum M, Steinhertz PG. Radiation myelitis in a 5-year-old girl. J Child Neurol 17:217-219, 2002.


34.   Sandberg DI, Edgar MA, Souweidane MM. Effect of hypersomolar mannitol on convection-enhanced delivery into the rat brain stem. J Neuro-Oncol 58:187-192, 2002.


35.   Sandberg DI, Edgar MA, Souweidane MM. Convection-enhanced delivery into the rat brain stem. J Neurosurg 96:885-891, 2002.


36.   Weiner HL, Lichtenbaum RA, Wisoff JH, Souweidane MM, Bruce JN, Snow RB, Finlay JL. Delayed surgical resection for central nervous system germ cell tumors. Neurosurgery 50:727-734, 2002.


37.   Sugiultzoglu MK, Souweidane MM. Report of two cases of early management of craniocerebral injury with avoidance of post-traumatic leptomeningeal cyst formation. Pediatr Neurosurgery 35:329-333, 2001.


38.   Souweidane MM, Edgar MA, Rutka JT. Arachnoid infiltration in children with posterior fossa tumors. Neuro-Oncol 3 (Suppl 1):42-43, 2001.


39.   Sandberg DI, Edgar MA, Souweidane MM. Convection-enhanced delivery into the rat brain stem: A potential delivery mechanism for the treatment of diffuse pontine gliomas. Neuro-Oncol 3:295-296, 2001.


40.   Horska A, Ulug AM, Melhem ER, Filippi CG, Burgr PC, Edgar MA, Souweidane MM, Carson BS, Barker PB. Proton magnetic resonance spectroscopy of choroid plexus tumors in children. J Mag Resonance Imaging 14:78-82, 2001.


41.   Sandberg DI, Edgar MA, Resch L, Rutka JT, Becker LE, Souweidane MM. MIB-1 staining of pediatric meningiomas. Neurosurgery 48:590-597, 2001.


42.   Kramer K, Cheung NV, Humm JL, Dantis E, Finn R, Yeh SJ, Antunes NL, Dunkel IJ, Souweidane MM, Larson SM. Targeted radioimmunotherapy for leptomeningeal cancer using 131I-3F8. Med Pediatr Oncology 35:716-718, 2000.


43.   Souweidane MM, Sandberg DI, Bilsky MG, Gutin PH. Endoscopic biopsy for tumors of the third ventricle. Pediatr Neurosurgery 33:132-137, 2000.


44.   Antunes NL, Boulad F, Prasad V, Rosenblum M, Lis E, Souweidane MM. Rolandic encephalopathy and epilepsia partialis continua following bone marrow transplant. Bone Marrow Transplantation 26:917-919, 2000.


45.   Hirsch J, Ruge MI, Kim KHS, Correa DD, Victor JD, Relkin NR, Labar DR, Krol G, Bilsky MG, Souweidane MM, DeAngelis LM, Gutin PH. An integrated fMRI procedure for preoperative mapping of cortical areas associated with tactile, motor, language, and visual functions. Neurosurgery 47:711-722, 2000.


46.   Sandberg DI, Bilsky M, Souweidane MM, Bzdil J, Gutin PH. Ommaya reservoirs for the treatment of leptomeningeal metastases. Neurosurgery 47:49-55, 2000.


47.   Antunes NL, Tavora L, Souweidane MM: Globular glioma of the tectum. Pediatr Neurology 21:492-495, 1999.


48.   Souweidane MM, Johnson J, Lis E, Dunkel I. Volumetric reduction of a choroid plexus carcinoma using preoperative chemotherapy. J Neuro-Oncol 43:167-171, 1999.


49.   Souweidane MM, Kim KHS, McDowall R, Ruge MI, Lis E, Krol G, Hirsch J. Brain mapping in infants and young children with passive-functional magnetic resonance imaging. Pediatr Neurosurgery 30:86-92, 1999.


50.   Sandberg DI, Souweidane MM. Hemifacial spasm caused by pilocytic astrocytoma of the fourth ventricle. Pediatr Neurol 21:754-756, 1999.


51.   Ruge MI, Victor J, Souweidane MM, Bilsky M, Gutin PH, Hirsch J. Identification of pre and post central sulcus by functional magnetic resonance imaging and electrophysiology: comparison in 16 cases. J Cognitive Neurosci (Suppl):30, 1999.


52.   Sandberg DI, Souweidane MM. Endoscopic-guided proximal catheter placement in the treatment of posterior fossa cysts. Pediatr Neurosurg 30:180-185, 1999.


53.   Souweidane MM, Bouffet E, Finlay J. The Role of Chemotherapy in Newly Diagnosed Ependymoma of Childhood. Pediatr Neurosurgery 28:273-278, 1998.


54.   Souweidane MM, Drake JM. Retethering of Fibrolipomatous Filum Terminales. Neurosurgery 42:1390-1393, 1998.


55.   Souweidane MM, Kim KHS, McDowall R, Ruge MI, Lis E, Krol G, Hirsch J. Passive functional magnetic resonance imaging in pediatric neurosurgery. Child’s Nerv Syst 14:471, 1998.


56.   Hirsch J, Kim KHS, Souweidane MM, Ruge MI, Correa DD, Moreno D, McDowall R, Krol G. Passive listening during fMRI reveals an extensive receptive language system in young and sedated children. Neuroimage 7 (4): S513, 1998.


57.   Hirsch J, Kim KHS, Souweidane MM, Ruge MI, Correa DD, McDowall R. fMRI evidence for a top-down influences on the human infant primary visual system. Invest Opth Visual Sci (Suppl) 39:862, 1998.


58.   Souweidane MM, Gamache Jr, F. Endoscopic-guided Treatment of a Retrocerebellar Arachnoid Cyst. Outcomes: Clinical Results in Neuroendoscopy 2 (4), December 1996.   


59.   Souweidane MM, Hoffman HJ. Current Concepts in the Treatment of Pediatric Thalamic Tumors. Journal of Neuro-Oncology 28: 157-166, 1996.


60.   Souweidane MM, Rutka JT. Posterior Fossa Tumors in Children. Contemporary Neurosurgery 17 (26), 1995.


61.   Souweidane MM, Benjamin V. Spinal Meningiomas. Neurosurgery Clinics of North America 5: 283-292, 1994.

Honors and Awards

Pediatric Brain Tumor Foundation Research Grant      2007-2008

Lehman Brothers Foundation Award            2006-2009

Beez Foundation Research Grant            2005-2006

Isabel Gloria Neidorf Research Grant            2004-2007

Resident Teaching Award

Department of Neurological Surgery (NYPH-WMC)      2004, 2005

Save a Child's Heart Foundation               2003

Emily Dorfman Foundation for Children            2001-2003 

Children's Brain Tumor Foundation, Project Program Grant   2000

Medical Doctorate Degree with Distinction         1988 

Alpha Omega Alpha Inductee                1988 

Bachelors of Science Degree with High Honors         1983

James B. Angell Scholar Recipient            1982, 1983