Mehraneh D. Jafari, M.D.

Colon and Rectal Surgery

Locations and Appointments

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Personal Statement

My goal as a surgeon is to bring world class care to my patients. I believe that getting to know the patient’s goals which directly help our elite multidisciplinary team of oncologist, radiation oncologist and gastroenterologist towards precision medicine that will allow for goal directed therapy with minimal impact on quality of life. 

Biographical Info

Mehraneh Dorna Jafari, MD, is Associate Professor of Surgery at Weill Cornell Medical College and Chief of Colorectal Surgery at NewYork-Presbyterian Brooklyn Methodist Hospital. She is the director of clinical research in the department of Surgery at Weill Cornell Medical Center. She is board-certified in general surgery and colon and rectal surgery. Dr. Jafari specializes in the comprehensive care of colorectal cancer patients, patients with peritoneal surface disease as well as those patients with benign colorectal disease.

Dr Jafari works with a world-renowned group of multidisciplinary specialists to help promote a patient centered treatment plan for her patients, including radiation oncologists, medical oncologists, radiologists, pathologists, gastroenterologists, and interventional radiologists. Her goal is to provide precision medicine to patients that is safe and effective.

Dr. Jafari has expertise in minimal access techniques, including laparoscopic, and robotic surgery. In addition, she has special interests in sphincter preserving surgery (helping rectal cancer patients avoid a permanent ostomy), maintaining fertility in cancer patients, and improving quality of life and bowel function after rectal surgery.  Dr Jafari has been at forefront of research with regards to improving outcomes using enhanced recovery and narcotic sparing protocols.

Dr. Jafari is among a small number of surgeons who offers surgery for metastatic colon, appendiceal and peritoneal surface disease. She utilizes cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC), which involves heated chemotherapy applied directly within the abdominal cavity following removal of cancerous tumors.

Dr. Jafari’s clinical research focuses on quality of life and oncological outcomes for colorectal cancer patients. Her main area of expertise is starting chemotherapy earlier in cancer treatment to allow patients to recover their quality of life sooner.

Dr. Jafari has written extensively and published in many major journals, including the Journal of the American Medical Association (JAMA), Annals of Surgery, and the Journal of the American College of Surgeons. She has led numerable courses teaching surgeons around the country how to perform minimal invasive surgery.

Dr. Jafari is actively involved in many national Surgical and Oncologic Societies, including the American College of Surgeons, Society of Surgical Oncologists, American Society of Colon and Rectal Surgeons and Association of Women Surgeons.

Dr. Jafari completed her general surgical residency at University of California, Irvine and her Colorectal fellowship at NYP Weill Cornell/Columbia & Memorial Sloan Kettering Cancer Center. She then was appointed the as Director Education for the Department of Surgery and Associate program Director of Colon and Rectal Surgery at University of California, Irvine prior to joining Weill Cornell.


Board Certifications
American Board of Colon & Rectal Surgery
American Board of Surgery
Clinical Expertise
Colon Cancer
Rectal Cancer
HIPEC (Hyperthermic Intraperitoneal Chemotherapy)
Anal Cancer
Rectal Surgery
Robot-Assisted Surgery
Robotic Surgery
Laparoscopic Colon and Rectal Surgery
Complex Pelvic Surgery
Intestinal Fistula Surgery
Recurrent Colorectal Cancer
Colorectal Cancer
Colon/Rectal Cancer Surgery
Laparoscopic Colon Surgery
Minimally Invasive Surgery
Complex Anal Fistula Disease
Inflammatory Bowel Disease (IBD)
Bowel-Sparing Strictureplasty
Crohn's Disease
Endoscopic Surgery
Diverticular Disease
Rectal Prolapse
Anal Fistula
Bowel Dysfunction
Ulcerative Colitis
Pelvic Surgery
Hemorrhoid Surgery
Sphincter Sparing Surgery
Surgery For Ulcerative Colitis
Bowel Obstruction
Anal Fissure
Computer Assisted Surgery
Minimally Invasive Robotic Surgery
Da Vinci Robotic Surgery
  • M.D.
    Drexel University College of Medicine
  • B.S.
    University of California, Irvine
  • Associate Attending Surgeon
    NewYork-Presbyterian Hospital
  • Associate Professor of Clinical Surgery (Pending Appointment at Rank)
    Weill Cornell Medical College, Cornell University
  • Associate Attending Surgeon
    NewYork-Presbyterian/Brooklyn Methodist Hospital

Relationships and collaborations with for-profit and not-for profit organizations are of vital importance to our faculty because these exchanges of scientific information foster innovation. As experts in their fields, WCM physicians and scientists are sought after by many organizations to consult and educate. WCM and its faculty make this information available to the public, thus creating a transparent environment.

No External Relationships Reported