Ben-Gary Harvey, M.D.
Pulmonary Disease Medicine
Publications
Vincent T, Harvey B-G, Hogan SM, Bailey CJ, Crystal RG, Leopold PL. Rapid assessment of adenovirus serum neutralizing antibody titer based on quantitative, morphometric evaluation of capsid binding and intracellular trafficking. J Virol 2001; 75: 1516-1521.
Harvey B-G, Hackett NR, Ely S, Crystal RG. Host responses and persistence of vector genome following intrabronchial administration of an E1-E3- adenovirus gene transfer vector to normal individuals. Molecular therapy 2001; 3: 206-215.
Crystal RG, Harvey B-G, Wisnivesky JP, O#146;Donoghue KA, Chu KW, Maroni J, Muscat JC, Pippo AL, Wright CE, Kaner RJ, Leopold PL, Kessler PD, Rasmussen HS, Rosengart TK, Hollmann C. Analysis of risk factors for local delivery of low and intermediate dose adenovirus gene transfer vectors to individuals with a spectrum of comorbid conditions. Hum Gene Ther 2002; 13: 65-100.
Harvey B-G, Maroni J, O#146;Donoghue K, Chu K, Muscat J, Pippo A, Wright C, Hollmann C, Wisnivesky J, Kessler PD, Rasmussen HS, Rosengart TK, Crystal RG. Safety of local delivery of low and intermediate dose adenovirus gene transfer vectors to individuals with a spectrum of comorbid conditions. Hum Gene Ther 2002; 13: 15-65.
Harvey B-G, McKinney RL., Rosengart, T., Lesser ML., and Crystal RG. Systemic Interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes. Molecular Therapy 2002; 6: 287-297
Hackett NR, Heguy A, Harvey B-G, Luettich K, Kaplan R, Crystal RG. Individual variability of gene expression in the human airway epithelium responding to the stress of cigarette smoking. American Journal of Respiratory Cell and Molecular Biology 2003; 29:332-343.
Kaplan R, Luettich K, Heguy A, Hackett NR, Harvey B-G, Crystal RG. Monoallelic upregulation of the imprinted H19 gene in airway epithelium of phenotypically normal cigarette smokers. Cancer Research 2003; 63: 1475-1482.
Heguy A, Harvey B-G, O#146;Connor TP, Hackett NR, Crystal RG. Sampling dependent upregulation of gene expression in sequential samples of human airway epithelial cells. Mol Med 2003; 9: 200-208.
Worgall S, Heguy A, Kuettich K, O'Connor TP, Harvey B-G, Quadri LEN, Crystal RG. Similarity of patterns in gene expression of human alveolar macrophages evoked by Pseudomonas aeruginosa and Burkholderia cepacia. Infect Immun 2005; 73: 5262-5268.
Heguy A, O'Connor TP, Luettich K, Worgall S, Cieciuch AA, Harvey B-G, Hackett NR, Crystal RG. Gene expression profiling of human alveolar macrophages of phenotypically normal smokers and non-smokers reveals a previously unrecognized subset of genes modulated by cigarette smoking. J Mol Med 2006; 84:318-328.
Harvey B-G, Heguy A, Leopold PL, Ferris B, Crystal RG. Modification of gene expression of the small airway epithelium in response to cigarette smoking. J Mol Med 2007; 86:39-53.
Carolan BJ, Heguy A, Harvey B-G, Leopold PL, Ferris B. Upregulation of expression of the ubiquitin carboxyl terminal hydrolase L 1 gene in human airway epithelium of cigarette smokers. Ca Res 2006; 66:10729-10740
Heguy A, Harvey B-G, Leopold PL, Dolgalev I, Raman T, Crystal RG. Related responses of the human airway epithelium transcriptome to in vivo injury. Physiol Genomics 2007; 29:139-148.
Ammous Z, Hackett NR, Butler MW, Raman T, Dolgalev I, O'Connor TP, Harvey BG, Crystal RG. Variability in small airway epithelial gene expression among normal
smokers. Chest. 2008 Jun;133(6):1344-53. Epub 2008 Mar 13. PubMed PMID: 18339782.
Kazeros A, Harvey BG, Carolan BJ, Vanni H, Krause A, Crystal RG.
Overexpression of apoptotic cell removal receptor MERTK in alveolar macrophages
of cigarette smokers. Am J Respir Cell Mol Biol. 2008 Dec;39(6):747-57. Epub 2008
Jun 27. PubMed PMID: 18587056; PubMed Central PMCID: PMC2586050.
Carolan BJ, Harvey BG, De BP, Vanni H, Crystal RG. Decreased expression of
intelectin 1 in the human airway epithelium of smokers compared to nonsmokers. J
Immunol. 2008 Oct 15;181(8):5760-7. PubMed PMID: 18832735; PubMed Central PMCID: PMC2651682.
Tilley AE, Harvey BG, Heguy A, Hackett NR, Wang R, O'Connor TP, Crystal RG.
Down-regulation of the notch pathway in human airway epithelium in association
with smoking and chronic obstructive pulmonary disease. Am J Respir Crit Care
Med. 2009 Mar 15;179(6):457-66. Epub 2008 Dec 23. PubMed PMID: 19106307; PubMed Central PMCID: PMC2654975.
Vanni H, Kazeros A, Wang R, Harvey BG, Ferris B, De BP, Carolan BJ, Hübner RH,
O'Connor TP, Crystal RG. Cigarette smoking induces overexpression of a
fat-depleting gene AZGP1 in the human. Chest. 2009 May;135(5):1197-208. Epub 2009
Feb 2. PubMed PMID: 19188554; PubMed Central PMCID: PMC2679098.
Shaykhiev R, Krause A, Salit J, Strulovici-Barel Y, Harvey BG, O'Connor TP,
Crystal RG. Smoking-dependent reprogramming of alveolar macrophage polarization:
implication for pathogenesis of chronic obstructive pulmonary disease. J Immunol.
2009 Aug 15;183(4):2867-83. Epub 2009 Jul 27. PubMed PMID: 19635926.
