Costantino Iadecola, M.D.

Neurology
Costantino Iadecola

Costantino Iadecola, MD
Dr. Iadecola received the MD degree from the University of Rome, Italy, in 1977, wherein he pursued neurology training with Prof. Cesare Fieschi. In 1980, he joined Cornell University first as a post-doctoral fellow with Dr. Donald Reis, and then as Neurology Resident with Dr. Fred Plum. In 1990, Dr. Iadecola was recruited to the Department of Neurology of the University of Minnesota, where he rose through the academic ranks serving as Professor and Vice-Chair for Research from 1997 to 2001. In 2001, Dr. Iadecola was recruited back to Cornell as Director of the Division of Neurobiology, a post previously held by his mentor Dr. Reis. In 2012, Dr. Iadecola was named Director of the Brain and Mind Research Institute, a new entity with departmental privileges representing a hub for translational neuroscience research at Weill Cornell. He was also appointed the Anne Parrish Titzell Professor of Neurology, a prestigious chair previously held by Drs. Harold Wolff, Fred Plum, and Flint Beal.

Dr. Iadecola’s research focuses on the mechanisms of normal and abnormal cerebrovascular regulation, and on the molecular pathology of ischemic brain injury and neurodegeneration. A major area of interest deals with the interactions between cardiovascular risk factors, stroke and Alzheimer’s disease. His laboratory is a fertile training ground for junior faculty, post-doctoral fellows, graduate and medical students. Dr. Iadecola has published more that 230 papers in peer reviewed journals. He is active in several national and international research organizations and funding agencies. He has served on the Research Committee of the American Heart Association (AHA) and on the Stroke Council. He has chaired the Program Committee of the International Stroke Conference. He participates in focus groups and review committees at the NIH. He has been the President (Chair) of the Scientific Advisory Committee of the Fondation Leducq and is an advisor to the Canadian Stroke Network, the European Stroke Network and the German Stroke Network. He also serves on the scientific advisory board of the Cluster for Systems Neurology (SyNergy), TargetBrain European Union Consortium, DHU NeuroVasc Sorbonne Paris-Cite, and the Munich Institute of Stroke and Dementia Research. He is a member of the Stroke Section Strategic Plan of the American Academy of Neurology.

Dr. Iadecola is Consulting Editor for Stroke, the leading journal for cerebrovascular diseases, and Reviewing Editor for the Journal of Neuroscience, the official journal of the Society for Neuroscience. He serves as Guest Editor for Hypertension,  for Circulation and for the Proceeding of the National Academy or Sciences. He is a member of the editorial board of the Annals of Neurology, Cellular and Molecular Neurobiology, Cerebrovascular Diseases, and the Journal of Cerebral Blood Flow and Metabolism. He has received the Laurence McHenry Award from the American Academy of Neurology, the Louis Sklarow Memorial Award, the Established Investigator Award from the AHA, the Jacob Javits Award from National Institute of Neurological Disorders and Stroke, NIH. In 2009, Dr. Iadecola received the Willis Award, the highest honor bestowed by the AHA, in recognition of his outstanding accomplishments in the field of stroke and cerebrovascular diseases. In 2011 he received the Zenith Award from the Alzheimer's Association for his research on the relationship between Alzheimer pathology and hypertension. His work has been consistently funded since the 1980s by the NIH and the American Heart Association.

Publications

Iadecola C, Zhang F, Niwa K, Eckman C, Younkin S, Turner SK, Fischer E, Borchell D, Hsiao KK and Carlson GA: SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Nat Neurosci. 2: 157-161, 1999.

Niwa K, Araki E, Morham S, Ross ME and Iadecola C: Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex. J Neurosci. 20: 763-770, 2000.

Niwa K, Younkin L, Ebeling C, Turner SK, Westaway D, Younkin S, Hsiao Ashe K, Carlson GA and Iadecola C: Aß1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation. Proc Natl Acad Sci (USA), 97: 9735-9740, 2000.

Yang G, Huard J, Beitz AJ, Ross ME and Iadecola C: Stellate neurons mediate functional hyperemia in cerebellar molecular layer. J Neurosci. 20: 6968-6973, 2000.

Iadecola C, Niwa K, Nogawa S, Zhao X, Nagayama M, Araki E, Morham S and Ross ME: Reduced susceptibility to ischemic brain injury and NMDA-mediated neurotoxicity in cyclooxygenase-2 deficient mice. Proc Natl Acad Sci (USA), 98: 1294-1299, 2001.

Iadecola C: Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci. 5: 347-360, 2004.

Wang G, Anrather J, Huang J, Speth RB, Pickel VM and Iadecola C: NADPH oxidase contributes to angiotensin II signaling in the nucleus tractus solitarius. J Neurosci. 24: 5516-5524, 2004.

Kazama K, Anrather J, Zhou P, Girouard H, Frys K, Milner TA and Iadecola C: Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circ Res. 95: 1019-1026, 2004.

Park L, Anrather J, Zhou P, Frys K, Pitstick R, Younkin S, Carlson GA and Iadecola C: NADPH oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. J Neurosci. 25: 1769-1777, 2005.

Cho S, Park EM, Febbraio M, Anrather J, Park L, Racchumi G, Silverstein RL and Iadecola C: The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia. J Neurosci. 25: 2504-2512, 2005.

Kawano T, Anrather J, Zhou P, Park L, Wang G, Frys KA, Kunz A, Cho S, Orio M and Iadecola C: Prostaglandin E2 EP1 receptors: Downstream effectors of COX-2 neurotoxicity. Nat Med. 12: 225-229, 2006.

Girouard H, Park L, Anrather J, Zhou P and Iadecola C: Cerebrovascular nitrosative stress mediates neurovascular and endothelial dysfunction induced by angiotensin II. Arterioscler Thromb Vasc Biol. 27: 303-309, 2007.

Iadecola C: Astrocytes take center stage in salt sensing. Neuron, 54: 3-5, 2007.

Kunz A, Park L, Abe T, Gallo EF, Anrather J, Zhou P and Iadecola C: Neurovascular protection by ischemic tolerance: role of nitric oxide and reactive oxygen species. J Neurosci. 27: 7083-7093, 2007.

Iadecola C and Nedergaard M: Glial regulation of the cerebral microvasculature. Nat Neurosci. 10: 1369-1376, 2007.

Kunz A, Abe T, Hochrainer K, Shimamura M, Anrather J, Racchumi G, Zhou P and Iadecola C: Nuclear factor-kb activation and post-ischemic inflammation are suppressed in CD36-null mice after middle cerebral artery occlusion. J Neurosci. 28: 1649-1658, 2008.

Park L, Zhou P, Pitstick R, Capone C, Anrather J, Norris EH, Younkin L, Younkin S, Carlson G, McEwen BS and Iadecola C: Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proc Natl Acad Sci (USA), 105: 1347-1352, 2008.

Park L, Gallo EF, Anrather J, Wang G, Norris EH, Paul J, Strickland S and Iadecola C: Key role of tissue plasminogen activator in neurovascular coupling. Proc Natl Acad Sci (USA), 105: 1073-1078, 2008.

Girouard H, Wang G, Gallo EF, Anrather J, Zhou P, Pickel VM and Iadecola C: NMDA receptor activation increases free radical production through nitric oxide and NOX2. J Neurosci. 29: 2545-2552, 2009.

Capone C, Anrather J, Milner TA and Iadecola C: Estrous cycle dependent neurovascular dysfunction induced by angiotensin II in the mouse neocortex. Hypertension, 54: 302-307, 2009.

Iadecola C: Bleeding in the brain: Killer waves of depolarization in subarachnoid bleed. Nat Med. 15: 1131-1132, 2009.

Yin F Banerjee R, Thomas B, Zhou P, Qian L, Jia T, Ma X, Ma Y, Iadecola C, Beal MF, Nathan C and Ding A: Exaggerated Inflammation and Brain Dysfunction in Progranulin- Deficient Mice. J Exp Med. 207: 117-128, 2010.

Capone C, Faraco, G, Anrather J, Zhou P and Iadecola C: COX-1-derived prostaglandin E2 and EP1 receptors are required for the cerebrovascular dysfunction induced by angiotensin II. Hypertension, 55 :911-917, 2010.

Abe T, Shimamura M, Jackman K, Kurinami H, Anrather J, Zhou P and Iadecola C: Key role of CD36 in Toll-like receptor 2 signaling in cerebral ischemia. Stroke, 41:898-904, 2010.

Iadecola C: The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropath, 120: 287-296, 2010.

Moskowitz MA, Lo E and Iadecola C: The Science of Stroke: Mechanisms in Search of Treatments. Neuron, 67: 181-198, 2010.

Coleman C, Wang G, Park L, Anrather J, Delagrammatikas G, Chan J, Zhou J, Iadecola C and Pickel VM: Chronic intermittent hypoxia induces NMDA receptor-dependent plasticity and suppresses nitric oxide signaling in the mouse hypothalamic paraventricular nucleus. J Neurosci. 30: 12103-12112, 2010.

Gallo EF, Iadecola C: Balancing life and death in the ischemic brain: SIK and TORK weigh in. Neuron, 69: 3-6, 2011.

Newelt EA, Bauer B, Fahlke C, Fricker G, Iadecola C, Janigro D, Leybaert L, Molnar Z, O'Donnell M, Povlishock J, Saunders N, Sharp F, Stanimirovic D, Watts R and Drewes L: Engaging Neuroscience to Advance Translational Research in Brain Barrier Biology. Nat Rev Neurosci. 12: 169-182, 2011.

Park L, Wang G, Zhou P, Zhou J, Pistick R, Previti ML, Younkin L, Younkin S, Van Nostrand WE, Cho S-G, Anrather J, Carlson G and Iadecola C: The scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-b. Proc Natl Acad Sci (USA), 108: 5063-5068, 2011.

Iadecola C and Anrather J: The immunology of stroke: from mechanisms to translation. Nat Med. 17: 796-808, 2011.

Gallo EF and Iadecola C: Neuronal Nitric Oxide Contributes to Neuroplasticity-Associated Protein Expression through cGMP, Protein Kinase G, and Extracellular Signal-Regulated Kinase. J Neurosi. 31: 6947-6955, 2011.

Gorelick PB, Scuteri A, Black SE, DeCarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW and Seshadri S: Vascular Contributions to Cognitive Impairment and Dementia. Stroke, 42: 2672-2713, 2011.

Iadecola C and Anrather J: Stroke research at a crossroad: asking the brain for directions. Nat Neurosci. 14: 1363-1368, 2011.

Zhou P Qian L, D'Aurelio M, Cho S, Wang G, Manfredi G, Pickel VM and Iadecola C: Prohibitin Reduces Mitochondrial Free Radical Production and Protects Brain Cells from Different Injury Modalities. J Neurosci. 32: 583-592, 2012.

Capone C, Faraco G, Peterson J, Coleman C, Anrather J, Milner TA, Pickel VM, Davisson RL and Iadecola C: Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin-II hypertension. J Neurosci. 32:4878-4886, 2012.

Kamel, H., Johnston, S.C., Kirkham, J. C., Turner, C. G., Kizer, J. R., Devereux, R.B., and Iadecola, C.: Association Between Major Perioperative Hemorrhage and Stroke or Q-Wave Myocardial Infarction. Circulation, 126:207-212, 2012

Garcia-Bonilla, L., and Iadecola: Peroxiredoxin sets the brain on fire after stroke. Nature Medicine, 18:858-859, 2012

Young, C., Cao X., Guruju, M., Pierce, J., Morgan, D., Wang, G., Iadecola, C., Mark, A.L., Davisson R.L.: Endoplasmic Reticulum Stress in the Brain Subfornical Organ Mediates Angiotensin-Dependent Hypertension. J. Clin Invest., 122: 3960-4, 2012

Woo, M-S, Wang, X., Faustino, J.V., Derugin, N., Wendland, M.F., Zhou, P., Iadecola, C., Vexler, Z.S.: Genetic deletion of CD36 enhances injury after acute neonatal stroke. Ann Neurol, 72:961-970, 2012

Park L., Zhou, J., Zhou, P., Pistick, R., El Jamal, S., Younkin, L., Pierce, J., Arreguin, A., Anrather, J., Younkin, S.G., Carlson, G.C., McEwen, B., and Iadecola, C.: Innate immunity receptor CD36 promotes cerebral amyloid angiopathy. Proc. Natl. Acad. Sci. USA, 2013

Honors and Awards

Awards:

L.C. McHenry Award of the American Academy of Neurology (1990)

Dr. Louis Sklarow Award (1993)

Established Investigator of the American Heart Association (1993)

Javits Award by NINDS (1999)

Willis Award, American Heart Association-American Stroke Association (2009)

Zenith Fellow Award, Alzheimer's Association (2011)

 

Honors:

Board of Directors, International Society for Cerebral Blood Flow and Metabolism (1997-2001).

Member, Program Committee, International Stroke Conference, American Heart Association (2000-2009)

Chair, Program Committee, International Stroke Conference, American Heart Association (2005-2006)

Chair, Brain Study Group 1, American Heart Association, (2001-2003)

Member, Research Committee, American Heart Association, (2001-2006)

Chair, National Research Programs Subcommittee, American Heart Association (2003-2005)

Member, Leadership Committee, Stroke Council, American Heart Association, (2001-2007)

Chair, Membership Committee, International Society for Cerebral Blood Flow and Metabolism (2001-2003)

Member, Program Committee Brain 03 and 05 meetings, International Society for Cerebral Blood Flow and Metabolism (2004-2006)

Chair, Program Committee Brain 07 meeting, International Society for Cerebral Blood Flow and Metabolism (2006-2007)

Member, NSD-A Study Section, NINDS/NIH (2002-2005)

Chair, NSD-A Study Section, NINDS/NIH (2005-2007)

Chair, NHLBI Working Group on Cerebrovascular Biology and Disease (2005)

Co-Chair, NINDS-CSN Vascular Cognitive Impairment Harmonization Standards (2005)

Chair, Bugher Centers Review, American Heart Association (2007)

Member, Program Committee Brain 09, International Society for Cerebral Blood Flow and Metabolism (2009)

President, Scientific Advisory Committee, Fondation Leducq (2009-2012)

Cluster for Systems Neurology (SyNergy) (2013-present)

TargetBrain European Union Consortium (2012-present)

DHU NeuroVasc Sorbonne Paris-Cite (2012-present)

Munich Institute of Stroke and Dementia Research (2011-present)

Stroke Section Strategic Plan, American Academy of Neurology.

 

Editorial Boards:

Journal of Neuroscience (2004-2007; Reviewing Editor: 2007- present)

Annals of Neurology (2007- present)

Journal of Cerebral Blood Flow and Metabolism (1996- present)

Stroke (1997-2000; Associate Editor, Basic Science: 2000- 2010; Consulting Editor: 2010-present)

American Journal of Physiology (Heart and Circ. Physiology) (1999-2012)

Cognitive Sciences (2007- present)

Proceedings of the National Academy of Sciences (Guest Editor)

Circulation (Guest Editor)

Hypertension (Guest Editor)