Hugh C. Hemmings, Jr., M.D., Ph.D.
Hugh C. Hemmings Jr., MD, PhD, FRCA is Distinguished Research Professor in Anesthetic Mechanisms, Professor of Anesthesiology and Pharmacology and Chair of Anesthesiology at Weill Cornell Medical College, and Anesthesiologist-in-Chief at NewYork Presbyterian Hospital/Weill Cornell. Dr. Hemmings earned a BS in Biochemistry from Yale College, a Ph.D. in pharmacology from Yale University, and an M.D. from Yale Medical School. His Ph.D. work in the laboratory of Paul Greengard, Ph.D. was cited in his 2000 Nobel Prize in Physiology and Medicine. He completed postdoctoral work at The Rockefeller University, a residency in anaesthesia at the Massachusetts General Hospital, and a fellowship in cardiac anesthesia at NewYork Presbyterian Hospital-Weill Cornell Medical Center, where he has been a faculty member for 21 years.
An internationally recognized neuropharmacologist, Dr. Hemmings is an expert in the synaptic effects of general anesthetics and mechanisms of neuronal signal transduction. His research in these areas is supported by grants from the National Institutes of Health. He is active in several national and international societies for anesthesiology and neuroscience, and serves as an Editor for the journals Anesthesiology and the British Journal of Anaesthesia. He was elected as Fellow of the Royal College of Anaesthetists in 2012. Dr. Hemmings has authored more than 100 articles in anesthesiology and neuroscience, and has edited four books, including Pharmacology & Physiology for Anesthesia: Foundations and Clinical Application published in 2013.
A summary of Dr. Hemmings's Education, Training and/or Faculty Appointments is listed as following:
1985-1987 Postdoctoral Associate, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York
1987-1988 Intern, Department of Internal Medicine, Hospital of Saint Raphael, New Haven, Connecticut
1988 Research Associate, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York
1988-2000 Guest Investigator, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York
1989-1991 Resident, Department of Anaesthesia, Massachusetts General Hospital, Boston, Massachusetts
1991 Fellow in Cardiac Anesthesia, Department of Anesthesiology, The New York Hospital, New York, New York
1991-1995 Assistant Professor of Anesthesiology, Cornell University Medical College, New York, New York
1991-1995 Assistant Attending Anesthesiologist, The New York Hospital, New York, New York
1991-1998 Assistant Professor of Pharmacology, Cornell University Medical College, New York, New York
1995-1999 Director of Research, Department of Anesthesiology, Cornell University Medical College, New York, New York
1996-2000 Associate Professor of Anesthesiology, Cornell University Medical College, New York, New York
1996-2000 Associate Attending Anesthesiologist, The New York Hospital, New York, New York
1998-2001 Associate Professor of Pharmacology, Weill Medical College of Cornell University, New York, New York
1999-2013 Vice Chair for Research, Department of Anesthesiology, Weill Medical College of Cornell University, New York, New York
2000-present Professor of Anesthesiology, Weill Medical College of Cornell University, New York, New York
2000-present Attending Anesthesiologist, Weill Medical College of Cornell University, New York, New York
2000-present Adjunct Faculty, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York
2001-present Professor of Pharmacology, Weill Medical College of Cornell University, New York, New York
2013-present Chair of Department of Anesthesiology, Weill Cornell Medical College, New York, New York
Insurance Plans Accepted
The following represents most of the managed care plans accepted by this physician. If your insurance carrier does not appear here please feel free to contact this physician or this physician's practice as they may have individual contracts not included on this site.
- AETNA [HMO]
- AETNA [Medicare]
- AETNA [PPO]
- Aetna - Weill Cornell [POS]
- Affinity Health Plan
- Empire Blue Cross/Blue Shield [HMO]
- Empire Blue Cross/Blue Shield [Mediblue (Senior)]
- Empire Blue Cross/Blue Shield [PPO]
- Empire Blue Cross/Blue Shield [EPO]
- Fidelis Care
- GHI [CBP]
- Health First
- Health Insurance Plan of NY (HIP)
- Health Insurance Plan of NY (HIP) [Medicare]
- Health Insurance Plan of NY (HIP) [Medicaid]
- Health Plus - Amerigroup
- Medicare [Medicare]
- Oxford Health Plans [Freedom]
- Oxford Health Plans [Liberty]
- Oxford Health Plans [Medicare Advantage]
- Rockefeller University - CoreSource
- United Empire
- United Health Care
- United Health Care [Medicare]
- United Health Care [Community Plan]
Herold, KF, Hemmings HCJr. Sodium channels as targets for volatile anesthetics. Front Pharmacol 2012; 3:50 (PMID: 22479247)
Westphalen RI, Kwak NB, Daniels K, Hemmings HC Jr. Regional differences in the effects of isoflurane on neurotransmitter release. Neuropharmacology. 2011 Sep;61(4):699-706.
Mantz J, Hemmings HC Jr. Sleep and anesthesia: the histamine connection.
Anesthesiology. 2011 Jul;115(1):8-9.
Hudson AE, Hemmings HC Jr. Are anaesthetics toxic to the brain? Br J Anaesth.
Hemmings HC Jr, Mackie K. The rivers of lethe and mnemosyne converge: propofol and memory consolidation. Anesthesiology. 2011 Jun;114(6):1277-9.
Hemmings HC Jr, Rosenberg AD, Reilly CS, Hunter JM. The 2010 BJA/PGA
supplement: a selection of 10 educational reviews. Br J Anaesth. 2010 Dec;105
Bendor J, Lizardi-Ortiz JE, Westphalen RI, Brandstetter M, Hemmings HC Jr,
Sulzer D, Flajolet M, Greengard P. AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. EMBO J. 2010 Aug
Hemmings HC Jr, Greengard P. Positively active: how local anesthetics work. Anesthesiology. 2010 Jul;113(1):250-2.
Westphalen RI, Yu J, Krivitski M, Jih TY, Hemmings HC Jr. Regional differences in nerve terminal Na channel subtype expression and Na channel-dependent glutamate and GABA release in rat CNS. J Neurochem. 2010 Jun;113(6):1611-20.
Glausier JR, Maddox M, Hemmings HC Jr, Nairn AC, Greengard P, Muly EC.
Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortex. Neuroscience. 2010 May 5;167(2):428-38.
Zhang Y, Guzinski M, Eger EI 2nd, Laster MJ, Sharma M, Harris RA, Hemmings HC Jr. Bidirectional modulation of isoflurane potency by intrathecal tetrodotoxin and veratridine in rats. Br J Pharmacol. 2010 Feb;159(4):872-8.
Mantz J, Hemmings HC Jr, Boddaert J. Case scenario: postoperative delirium in
elderly surgical patients. Anesthesiology. 2010 Jan;112(1):189-95.
Perouansky M, Hemmings HC Jr. Neurotoxicity of general anesthetics: cause for
concern? Anesthesiology. 2009 Dec;111(6):1365-71.
Twersky RS, Hemmings HC Jr. Introduction: 2009 BJA/PGA Supplement: a
selection of eight reviews. Br J Anaesth. 2009 Dec;103 Suppl 1:i1-2.
Herold KF, Nau C, Ouyang W, Hemmings HC Jr. Isoflurane inhibits the
tetrodotoxin-resistant voltage-gated sodium channel Nav1.8. Anesthesiology. 2009 Sep;111(3):591-9
Hemmings HC Jr. Sodium channels and the synaptic mechanisms of inhaled anaesthetics. Br J Anaesth. 2009 Jul;103(1):61-9. Review. PMID: 19508978
Perouansky M, Hemmings HC Jr. Between Clotho and Lachesis: how isoflurane seals neuronal fate. Anesthesiology. 2009 Apr;110(4):709-11. PMID: 19276964
Ouyang W, Herold KF, Hemmings HC Jr. Comparative effects of halogenated inhaled anesthetics on voltage-gated Na channel function. Anesthesiology. 2009 Mar;110(3):582-90. PMID: 19225394
Westphalen RI, Gomez RS, Hemmings HC Jr. Nicotinic receptor-evoked hippocampal norepinephrine release is highly sensitive to inhibition by isoflurane. Br J Anaesth. 2009 Mar;102(3):355-60. PMID: 19189985
Hemmings HC Jr, Mantz J. Xenon and the pharmacology of fear. Anesthesiology. 2008 Dec;109(6):954-5. PMID: 19034089
Zhang Y, Sharma M, Eger EI 2nd, Laster MJ, Hemmings HC Jr, Harris RA. Intrathecal veratridine administration increases minimum alveolar concentration in rats. Anesth Analg. 2008 Sep;107(3):875-8. PMID: 18713899
Eger EI 2nd, Raines DE, Shafer SL, Hemmings HC Jr, Sonner JM. Is a new paradigm needed to explain how inhaled anesthetics produce immobility? Anesth Analg. 2008 Sep;107(3):832-48. Review. PMID: 18713892
Hemmings HC Jr, Flood P. Galloping in full pursuit of the mechanism of anesthetic immobility. Anesthesiology. 2008 Jun;108(6):975-6. PMID: 18497595
Platholi J, Heerdt PM, Lim Tung HY, Hemmings HC Jr. Activation of brain protein phosphatase-1(I) following cardiac arrest and resuscitation involving an interaction with 14-3-3 gamma. J Neurochem. 2008 Jun;105(5):2029-38. Epub 2008 Feb 14. PMID: 18284617
Zhang TT, Platholi J, Heerdt PM, Hemmings HC Jr, Tung HY. Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation. Metab Brain Dis. 2008 Mar;23(1):95-104. Epub 2008 Jan 16. PMID: 18197471
Hemmings HC Jr. Noble meets nouveau: a shared anesthetic binding site for xenon and isoflurane on a glutamate receptor. Anesthesiology. 2007 Nov;107(5):694-6. PMID: 18073542
Westphalen RI, Krivitski M, Amarosa A, Guy N, Hemmings HC Jr. Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K channel, TREK-1. Br J Pharmacol. 2007 Nov;152(6):939-45. Epub 2007 Sep 10. PMID: 17828284
Snyder GL, Galdi S, Hendrick JP, Hemmings HC Jr. General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo. Neuropharmacology. 2007 Oct;53(5):619-30. Epub 2007 Jul 24. PMID: 17826804
OuYang W, Hemmings HC Jr. Isoform-selective effects of isoflurane on voltage-gated Na channels. Anesthesiology. 2007 Jul;107(1):91-8. PMID: 17585220
Ouyang W, Jih TY, Zhang TT, Correa AM, Hemmings HC Jr. Isoflurane inhibits NaChBac, a prokaryotic voltage-gated sodium channel. J Pharmacol Exp Ther. 2007 Sep;322(3):1076-83. Epub 2007 Jun 14. PMID: 17569823
Bullock SA, Platholi J, Gjyrezi A, Heerdt PM, Tung HY, Hemmings HC Jr. Differential regulation of protein phosphatase-1(I) by neurabin. Biochem Biophys Res Commun. 2007 Jun 22;358(1):140-4. Epub 2007 Apr 19. PMID: 17467665
Nguyen C, Nishi A, Kansy JW, Fernandez J, Hayashi K, Gillardon F, Hemmings HC Jr, Nairn AC, Bibb JA. Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5. J Biol Chem. 2007 Jun 1;282(22):16511-20. Epub 2007 Mar 30. PMID: 17400554
Hotte M, Thuault S, Dineley KT, Hemmings HC Jr, Nairn AC, Jay TM. Phosphorylation of CREB and DARPP-32 during late LTP at hippocampal to prefrontal cortex synapses in vivo. Synapse. 2007 Jan;61(1):24-8. PMID: 17068779
Bruening S, Oh E, Hetzenauer A, Escobar-Alvarez S, Westphalen RI, Hemmings HC Jr, Singewald N, Shippenberg T, Toth M. The anxiety-like phenotype of 5-HT receptor null mice is associated with genetic background-specific perturbations in the prefrontal cortex GABA-glutamate system. J Neurochem. 2006 Nov;99(3):892-9. Epub 2006 Aug 21. PMID: 16925594
Hemmings HC Jr, Antognini JF. Do general anesthetics add up? Anesthesiology. 2006 Jun;104(6):1120-2. PMID: 16732079
Hotte M, Thuault S, Lachaise F, Dineley KT, Hemmings HC, Nairn AC, Jay TM. D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex. Behav Brain Res. 2006 Jul 15;171(1):127-33. Epub 2006 May 9. PMID: 16687181
Westphalen RI, Hemmings HC Jr. Volatile Anesthetic Effects on Glutamate versus GABA Release from Isolated Rat Cortical Nerve Terminals: Basal Release. J Pharmacol Exp Ther. 2006 Jan;316(1):208-15.
Westphalen RI, Hemmings HC Jr. Volatile Anesthetic Effects on Glutamate versus GABA Release from Isolated Rat Cortical Nerve Terminals: 4-Aminopyridine-Evoked Release. J Pharmacol Exp Ther. 2006 Jan;316(1):216-23.
Hemmings HC Jr, Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL. Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci. 2005 Oct;26(10):503-10. Review. Foundations of Anesthesia: Basic Sciences for Clinical Practice 2e, HC Hemmings Jr, PM Hopkins, eds (2006; Mosby Elsevier, London).
Hemmings HCJr, Yan W, Westphalen RI, Ryan TA (2005) The general anesthetic isoflurane depresses synaptic vesicle exocytosis. Mol Pharmacol 67:1591-9.
Fu D, Vissavajjhala P, Hemmings HC Jr. (2005) Volatile anaesthetic effects on phospholipid binding to synaptotagmin 1, a presynaptic Ca2 sensor. Br J Anaesth. 95:216-21.
Futter M, Uematsu K, Bullock SA, Kim Y, Hemmings HC Jr, Nishi A, Greengard P, Nairn AC. (2005) Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5). Proc Natl Acad Sci USA 102:3489-94.
OuYang W, Wang G, Hemmings HC Jr. (2004) Distinct rat neurohypophysial nerve terminal populations identified by size, electrophysiological properties and neuropeptide content. Brain Res. 1024:203-11.
Ouyang W, Hemmings HC Jr. (2004) Depression by isoflurane of the action potential and underlying voltage-gated ion currents in isolated rat neurohypophysial nerve terminals. J Pharmacol Exp Ther. 312:801-8.
Morrow PW, Tung HY, Hemmings HC Jr. (2004) Rapamycin causes activation of protein phosphatase-2A1 and nuclear translocation of PCNA in CD4 T cells. Biochem Biophys Res Commun. 323:645-51.
Balint E, Kitka T, Zachar G, Adam A, Hemmings HC Jr, Csillag A. (2004)Abundance and location of DARPP-32 in striato-tegmental circuits of domestic chicks. J Chem Neuroanat. 28:27-36.
Hemmings HC Jr. (2004) Neuroprotection by Na channel blockade. J Neurosurg anesthesiol. 16:100-1. Review.
Honors and Awards
- Click here to visit the Hemmings Lab webpage
- 1977 Phi Beta Kappa
- 1978-1984 Medical Scientist Training Program Fellowship
- 1992-1994 Foundation for Anesthesia Education and Research/BOC Anesthesiology Young
- Investigator Award, The Effects of General Anesthetics on Presynaptic Protein Phosphorylation
- 1992-1996 Cornell Scholar in Biomedical Sciences, Synaptic Protein Phosphorylation as a Target for Anesthetic Action
- Vascular Anesthesia
- Cardiothoracic Anesthesia
Contact and Practices
- Ph.D., Yale University, 1987
- M.D., Yale University School of Medicine, 1987