Ethel Cesarman, M.D., Ph.D.

Anatomic Pathology and Clinical Pathology
Ethel Cesarman

Dr. Cesarman is trained in Anatomic Patology, nbsp;Hematopathology and Molecular Pathology. She serves as Assistant Director of the Molecular Hematopathology Laboratory of the New York Presbyterian Hospital / Weil Cornell. Dr. Cesarman's research focuses on malignancies associated with AIDS and other immunodeficiencies. Dr. Cesarman is Leader of the Pathology Core for the AIDS Malignancy Consortium and is involed in the diagnosis of these tumors in multiple national and international clinical trials.

Ongoing research in the Cesarman laboratory is aimed at characterizing the oncogenes encoded by KSHV and EBV, with the goal of dissecting the mechanism of transformation by these viruses and understanding their role in the development of malignant lymphoma or Kaposi's sarcoma. By characterizing the viral proteins that provide survival signals to the tumor cells, we are better understanding the role they play in carcinogenesis. The laboratory is currently developing inhibitors to these oncogenic viral proteins as a novel approach for the treatment of EBV- and KSHV-related malignancies.

EDUCATIONAL BACKGROUND:

MD-1981      Universidad Autonoma Metropolitana, Mexico City, Mexico.

MS-1984      Department of Pathology, New York University, New York.

Ph.D.-1990      Department of Pathology, New York University, New York.

 

PROFESSIONAL POSITIONS HELD:

1998-1991   Anatomic Pathology Resident- College of Physicians and Surgeons of

      Columbia University, New York.

1991-1992   Hematopathology Fellow- College of Physicians and Surgeons of

      Columbia University, New York.

1992-1993   Instructor of Pathology, College of Physicians and Surgeons of

      Columbia University, New York.

1993-1994   Assistant Professor of Pathology, College of Physicians and Surgeons of

      Columbia University, New York.

1994-1999   Assistant Professor of Pathology, Weill Medical College of Cornell University,          New York.

1994-1999 Assistant Attending Pathologist, New York Presbyterian Hospital, New York.   

1999-2007   Associate Professor of Pathology (Tenured), Weill Medical College of Cornell University, New York.

1999-Present  Associate Attending Pathologist, New York Presbyterian Hospital, New York.

2007-Present   Professor of Pathology and Laboratory Medicine (Tenured), Weill Medical College of Cornell University, New York.

 

PROFESSIONAL & LICENSURE:

1981       Licensed in Medicine, Mexico.

1982       ECFMG Certification.

1983       Federal Licensing Examination, Massachusetts.

1991       Medical License, New York State.

1991      Anatomic Pathology National Boards.

2007      Molecular Genetic Pathology National Boards

 

PROFESSIONAL MEMBERSHIPS:

1. American Society for Clinical Investigation

2. The American Society of Hematology

3. Association for Molecular Pathology

4. American Society for Microbiology

5. Henry Kunkel Society

6. American Association for Cancer Research

6. National Institutes of Health- Office of AIDS Research Grant study section AARR-4 on AIDS Malignancies and Opportunistic Infections (1999-2004)

Insurances

Insurance Plans Accepted

The following represents most of the managed care plans accepted by this physician. If your insurance carrier does not appear here please feel free to contact this physician or this physician's practice as they may have individual contracts not included on this site.

  • AETNA [HMO]
  • AETNA [PPO]
  • AETNA [Medicare]
  • Aetna - Weill Cornell [POS]
  • Affinity Essential
  • Affinity Health Plan
  • Blue Priority Network
  • CIGNA
  • Emblem Select Care
  • Empire Blue Cross/Blue Shield [Pathway X]
  • Empire Blue Cross/Blue Shield [Pathway X Enhanced]
  • Empire Blue Cross/Blue Shield [PPO]
  • Empire Blue Cross/Blue Shield [EPO]
  • Empire Blue Cross/Blue Shield [HMO]
  • Empire Blue Cross/Blue Shield [Mediblue (Senior)]
  • Fidelis Care
  • GHI [CBP]
  • Health First
  • Health Insurance Plan of NY (HIP) [Medicare]
  • Health Insurance Plan of NY (HIP)
  • Health Insurance Plan of NY (HIP) [Medicaid]
  • Health Plus - Amerigroup [CHP]
  • Health Plus - Amerigroup
  • Health Republic
  • Medicare [Medicare]
  • Oscar
  • Oxford Health Plans [Liberty]
  • Oxford Health Plans [Medicare Advantage]
  • Oxford Health Plans [Freedom]
  • POMCO
  • Rockefeller University - CoreSource
  • UHC Compass
  • United Empire
  • United Health Care
  • United Health Care [Medicare]
  • United Health Care [Community Plan]
  • VNSNY CHOICE Medicare [Medicare]
  • VNSNY CHOICE Medicare [HMO]

Publications

Representative of >140 publications:

  • Chang Y, Cesarman E, Pessin M, Lee F, Culpepper J, Knowles DM, Moore PS: Identification of new human herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science, 266:1865-1869, 1994.
  • Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM: Kaposi's sarcoma-associated herpesvirus-like DNA sequences are present in AIDS-related body cavity based lymphomas. New Engl J Med, 332:1186-1191, 1995.
  • Arvanitakis L, Geras-Raaka E, Gershengorn MC, Cesarman E. KS herpesvirus encodes a constitutively active G protein-coupled receptor linked to cell proliferation. Nature 385:347-350, 1997.
  • Flore O, Rafii S, Ely J, O'Leary JO, Hyjek EM, Cesarman E. Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus. Nature 394, 588-592, 1998.
  • Cesarman E. Kaposi's sarcoma-associated herpesvirus--the high cost of viral survival. N Engl J Med, 349:1107-1109,2003.
  • Guasparri I, Keller SA, Cesarman E. KSHV vFLIP is essential for the survival of infected lymphoma cells. J. Exp. Med. 199:993-1003, 2004.
  • Guasparri I, Bubman D, Cesarman E. EBV LMP2A mediated LMP1 signaling and survival of lymphoma cells through TRAF2 regulation. Blood, 111:3813-3820, 2008.
  • Di Bartolo D, Cannon M, Liu YF, Renne R, Chadburn A, Boshoff C, Cesarman E. Kaposi's sarcoma herpesvirus LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor. Blood, 111:4731-4740, 2008.
  • Chadburn A, Chiu A, Lee JY, Chen X, Hyjek E, Banham AH, Noy A, Kaplan LD, Sparano JA, Bhatia K, Cesarman E. Immunophenotypic analysis of AIDS-related diffuse large B-cell lymphoma and clinical implications in patients from AIDS Malignancies Consortium Clinical Trials 010 and 034. J Clin Oncology, 27:5039-48, 2009.
  • de Oliveira DE, Ballon G, Cesarman E. NF-kappaB signaling modulation by EBV and KSHV.& & Trends Microbiol. 18:248-57, 2010.
  •  Mesri MA, Cesarman E and Boshoff C.& Kaposi's sarcoma and its associated herpesvirus. Nature Reviews Cancer 10:707-19, 2010.
  • Krown SE, Dittmer DP, Cesarman E.& & Pilot Study of Oral Valganciclovir in Patients with Classic Kaposi Sarcoma. J. Infectious Diseases, 203:1082-6, 2011.
  • Ballon G, Chen K, Perez R, Tam W, and Cesarman E. Kaposi Sarcoma Herpesvirus (KSHV) vFLIP Induces B-cell Transdifferentiation and Tumorigenesis in Mice. J Clin Invest, 121:1141-1152, 2011.
  • Giulino L, Mathew S, Ballon G, Chadburn A, Barouk S, Antonicelli G, Leoncini L, Liu YF, Gogineni S, Tam W, Cesarman E. A20 (TNFAIP3) Genetic Alterations in EBV Associated AIDS Related Lymphoma. Blood,20:1114-1120, 2011.
  • Krown SE, Dittmer DP, Cesarman E.  Pilot Study of Oral Valganciclovir in Patients with Classic Kaposi Sarcoma. J. Infectious Diseases, 203:1082-6, 2011.
  • Mesri EA, Cesarman E. Kaposi's sarcoma herpesvirus oncogenesis is a Notch better in 3D. Cell Host Microbe10:529-31, 2011.
  •  Giulino Roth L, Wang K4, MacDonald TY, Mathew S, Tam Y, Cronin MT, Palmer G, Lucena-Silva N, Pedrosa F, Pedrosa M, Teruya-Feldstein J, Bhagat G, Alobeid B, Leoncini L, Bellan C, Rogena E, Pinkney KA, Rubin MA, Ribeiro RC, Yelensky R, Tam W, Stephens PJ, Cesarman E.  Targeted genomic sequencing of pediatric Burkitt lymphoma identifies recurrent alterations in anti-apoptotic and chromatin-remodeling genes. Blood, 120: 5181-4, 2012.
  • Mancuso M, Jiang L, Cesarman E, Erickson D. Multiplexed colorimetric detection of Kaposi's sarcoma associated herpesvirus and Bartonella DNA using gold and silver nanoparticles. Nanoscale. 5:1678-86, 2013.
  • Levine AM, Noy A, Lee JY, Tam W, Ramos JC, Henry DH, Parekh S, Reid EG, Mitsuyasu R, Cooley T, Dezube BJ, Ratner L, Cesarman E, Tulpule A. Pegylated liposomal doxorubicin, rituximab, cyclophosphamide, vincristine, and prednisone in AIDS-related lymphoma: AIDS Malignancy Consortium Study 047. J Clin Oncol. 31:58-64, 2013.
  • Byun M, Ma CS, Akçay A, Pedergnana V, Palendira U, Myoung J, Avery DT, Liu Y, Abhyankar A, Lorenzo L, Schmidt M, Lim HK, Cassar O, Migaud M, Rozenberg F, Canpolat N, Aydogan G, Fleckenstein B, Bustamante J, Picard C, Gessain A, Jouanguy E, Cesarman E, Olivier M, Gros P, Abel L, Croft M, Tangye SG, Casanova JL: Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J Exp Med 210:1743-59, 2013.

  • Wong LY, Brulois K, Toth Z, Inn KS, Lee SH, O'Brien K, Lee H, Gao SJ, Cesarman E, Ensser A, Jung JU: The product of KSHV K4.2 regulates immunoglobulin secretion and calcium homeostasis by interacting with and inhibiting pERP1. J Virol 87:12069-79, 2013.
  • Nayar U, Lu P, Goldstein RL, Vider J, Ballon G, Rodina A, Taldone T , Erdjument-Bromage H, Chomet M, Blasberg R, Melnick A, Cerchietti L, Chiosis G, Wang YL, Cesarman E: Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies. Blood 122:2837-47, 2013.
  • Damania B, Cesarman E: Chapter 65: Kaposi’s sarcoma-associated herpesvirus. In: Fields Virology. 6th Edition. Knipe DM and Howley PH (Eds). Lippincott Williams & Wilkins.  2080-2128, 2013.
  • Giulino-Roth L, Cesarman E: Molecular biology of Burkitt lymphoma. In: Burkitt’s Lymphoma. Robertson ES (Ed). Springer, New York, 2013.
  • Said J, Cesarman E, Knowles DM: Lymphadenopathy and the lymphoid neoplasms associated with HIV infection and other causes of immunosuppression. In: Knowles’ Neoplastic Hematopathology. 3rd Ed. Orazi A, Weiss L, Foucar K, Knowles DM (Eds). Lippincott Williams and Wilkins, Philadelphia, 2013.
  • Wang, YL, Cesarman E, Knowles DM: Antigen receptor genes: Structure, function, and molecular analysis in clinical applications. In: Knowles’ Neoplastic Hematopathology. 3rd Ed Orazi A, Weiss L, Foucar K, Knowles DM (Eds). Lippincott Williams and Wilkins, Philadelphia, 2013.
  • Cesarman E: Pathology of lymphoma in HIV. Curr Opinion Oncol 25:487-494, 2013.
  • Cesarman, E. Gammaherpesvirus and lymphoprolliferative disorders. Annu Rev Pathol, 9:349-72, 2014.
  • Jiang L, Mancuso M, Lu Z, Akar G, Cesarman E and Erickson D.  Solar thermal polymerase chain reaction for smartphone-assisted molecular diagnostics. Scientific Reports. In Press.

 

Honors and Awards

  • 1995 Arthur Purdy Stout Society of Surgical Pathologists Award for outstanding publication by yourn investigator in the field of surgical pathology by an investigator under the age of 40.
  • 2001-2006   Irma T Hirschl/Monique Weill- Caulier Career Scientist Award.
  • 2001 Member American Society for Clinical Investigation.
  • 2006 Member  Henry Kunkel Society

  • 2011-2013 Chair, General Faculty Council, Weill Cornell Medical College