Bruce B. Lerman, M.D.
Dr. Bruce B. Lerman is the H. Altschul Master Professor of Medicine, Chief of the Division of Cardiology and Director of the Electrophysiology Laboratory at Weill-Cornell and the New York Presbyterian Hospital. He received his medical degree from Loyola University - Stritch School of Medicine, was an intern and medical resident at Northwestern University and completed his cardiology fellowship at Johns Hopkins. He trained in cardiac electrophysiology at the University of Pennsylvania.
He has authored over 200 original publications, 60 book chapters and 2 books. He is a recipient of the Established Investigator Award from the American Heart Association and had received multiple grants from the NIH. He is currently on the editorial boards of Circulation, Heart Rhythm, Journal of Cardiac Electrophysiology, Pacing and Clinical Electrophysology and the Journal of Innovations in Cardiac Rhythm Management. He is a member of the exam writing committee of the American Board of Internal Medicine for the Cardiac Electrophysiology Board Examination..
His research contributions include elucidating the myriad electrophsyiologic mechanisms of the nucleoside adenosine, pioneering the concept of current-based defibrillation and determining the role of mechanoelectrical feedback as a stimulus for triggering malignant ventricular arrhythmias. His current work focuses on the the cellular and molecular mechanisms of ventricular outflow tract tachycardia. His laboratory has identified critical somatic mutations in the cAMP signal transduction cascade that mediate this form of ventricular tachycardia, thus introducing a new paradigm for the causation of ventricular tachycardia. He has been issued 4 patents.
He clinical concentration focuses on the diagnosis and treatment (ablation) of complex atrial and ventricular arrhythmias, as well as on the treatment of life-threatening arrhythmias with implantable devices. For the last 15 years, he’s been named in New York Magazine- Best Doctors, Castle Connolly – America’s Top Doctors, US News and World Report (Best Doctors) and the New York Times (Super Doctors).
Insurance Plans Accepted
The following represents most of the managed care plans accepted by this physician. If your insurance carrier does not appear here please feel free to contact this physician or this physician's practice as they may have individual contracts not included on this site.
- AETNA [PPO]
- AETNA [Medicare]
- AETNA [HMO]
- Aetna - Weill Cornell [POS]
- Affinity Health Plan
- Empire Blue Cross/Blue Shield [HMO]
- Empire Blue Cross/Blue Shield [EPO]
- Empire Blue Cross/Blue Shield [Mediblue (Senior)]
- Empire Blue Cross/Blue Shield [PPO]
- Fidelis Care
- GHI [CBP]
- Health First
- Health Insurance Plan of NY (HIP) [Medicaid]
- Health Insurance Plan of NY (HIP) [Medicare]
- Health Insurance Plan of NY (HIP)
- Health Plus - Amerigroup
- Medicare [Medicare]
- Oxford Health Plans [Liberty]
- Oxford Health Plans [Freedom]
- Oxford Health Plans [Medicare Advantage]
- Rockefeller University - CoreSource
- United Empire
- United Health Care [Community Plan]
- United Health Care [Medicare]
- United Health Care
To view complete list of peer-reviewed publications by Dr. Lerman: Click here
(Selected Publications 1995-)
Lerman BB, Engelstein ED. Metabolic determinants of defibrillation: Role of adenosine. Circulation 91:838-844, 1995
Stein KM, Karagounis LA, Anderson JL, Kligfield PK, Lerman BB. Fractal clustering of ventricular ectopy correlates with sympathetic tone preceding ectopic beats. Circulation 91:722-727, 1995
Okin PM, Stein KM, Lippman N, Lerman BB, Kligfield P. Performance of the signal-averaged electrocardiogram: Relationship to baseline QRS duration. Am Heart J 129:932-940, 1995
Lippman N, Stein KM, Lerman BB. Failure to decrease parasympathetic tone during upright tilt predicts a positive tilt table response. Am J Cardiol 75:591-595, 1995
Markowitz SM, Stein KM, Engelstein ED, Lerman BB. AV nodal-His-Purkinje reentry. A novel form of tachycardia. J Cardiovas Electrophysiol 6:400-409, 1995
Lerman BB, Stein KM, Engelstein ED, Battleman D, Lippman N, Bei D, Catanzaro. Mechanism of repetitive monomorphic ventricular tachycardia. Circulation 92:421-429, 1995
Gao S, Nadeem A, Deale OC, Lerman BB, Ng KT. Three-dimensional uniform grid modeling of electrical defibrillation on a data parallel computer. Computers in Biology and Medicine 25:335-348, 1995
Deale OC, Ng KT, Kim E, Lerman BB. Control of high common mode voltage during transthoracic defibrillation. IEEE Transactions on Biomedical Engineering 42:1208-1211, 1995
Lippman N, Stein KM, Lerman BB. Nonlinear forecasting and the dynamics of the cardiac rhythm. J Electrocardiol 28:65-70, 1995
Lerman BB, Engelstein ED. Increased threshold due to ventricular fibrillation duration: Potential Mechanisms. J Electrocardiol 28:521-524, 1995
Lerman BB, Stein KM, Markowitz SM. Adenosine-sensitive ventricular tachycardia: A conceptual approach. J Cardiovas Electrophysiol 7:559-569, 1996
Engelstein ED, Stein KM, Markowitz SM, Lerman BB. Posterior fast AV nodal pathways: Implications for radiofrequency catheter ablation. J Am Coll Cardiol 27:1098-1105, 1996
Lerman BB, Stein KM, Markowitz SM. Idiopathic right ventricular outflow tachycardia: A clinical approach. Pacing Clin Electrophysiol 19:2120-2137, 1996
Markowitz SM, Stein KM, Lerman BB. Mechanism of ventricular rate control following radiofrequency modification of atrioventricular conduction in patients with atrial fibrillation. Circulation 94:2856-2864, 1996
Ascheim DD, Markowitz SM, Lai H, Engelstein ED, Stein KM, Lerman BB. Vasodepressor syncope due to transient myocardial ischemia. J Cardiovasc Electrophysiol 8:215-221, 1997
Slotwiner D, Stein KM, Lippman N, Markowitz SM, Lerman BB. Response of neurocardiac syncope to b-blocker therapy: Interaction between age and parasympathetic tone. Pacing Clin Electrophysiol 20:810-814, 1997
Lerman BB, Stein KM, Markowitz SM. Mechanisms of idiopathic left ventricular tachycardia. J Cardiovasc Electrophysiol 8:571-583, 1997
Markowitz SM, Litvak BL, Ramirez de Arellano EA, Markisz JA, Stein KM, Lerman BB. Adenosine-sensitive ventricular tachycardia: Right ventricular abnormalities delineated by magnetic resonance imaging. Circulation 96;1192-1200, 1997
Lerman BB, Bei D, Stein KM, Markowitz SM, Linden J, Catanzaro DF. Right ventricular outflow tract tachycardia due to a somatic cell mutation in G protein subunit aI2. J Clin Invest 101:2862-2868, 1998
Stein KM, Karagounis LA, Markowitz SM, Anderson JL, Lerman BB. Heart rate changes preceding ventricular ectopy in patients with ventricular tachycardia caused by reentry, triggered activity and automaticity. Am Heart J 136:425-434, 1998
Mittal S, Stein KM, Markowitz SM, Slotwiner DJ, Rohatgi S, Lerman BB. Induction of neurally-mediated syncope with adenosine. Circulation 99:1318-1324, 1999
Lerman BB, Stein KM, Markowitz SM, Mittal S, Slotwiner D. Catecholamine facilitated reentrant ventricular tachycardia: Uncoupling of adenosine#146;s antiadrenergic effects. J Cardiovasc Electrophysiol 10:17-26, 1999
Markowitz SM, Stein KM, Mittal S, Slotwiner DJ, Lerman BB. Differential effects of adenosine on focal and macroreentrant atrial tachycardia. J Cardiovasc Electrophysiol 10:489-502, 1999
Christini DJ, Stein KM, Markowitz SM, Lerman BB. Practical real-time computing system for biomedical experiment interface. IEEE Trans Biomed Eng 27:180-186, 1999
Mittal S, Iwai S, Stein KM, Markowitz SM, Slotwiner DJ, Lerman BB. Long-term outcome of patients with unexplained syncope treated with an electrophysiologic guided approach in the implantable cardioverter-defibrillator era. J Am Coll Cardiol 34:1082-1089,1999
Stein KM, Walden J, Lippman N, Lerman BB. Ventricular response in atrial fibrillation: Random or deterministic? Am J Physiol 277:H452-H458,1999
Mittal S, Ayati S, Stein KM, Knight BP, Morady F, Schwartzman D, Cavlovich D, Platia EV, Calkins H, Tchou PJ, Miller JM, Wharton JM, Sung RJ, Slotwiner DJ, Markowitz SM, Lerman BB. Comparison of a novel rectilinear biphasic waveform with a damped sine wave monophasic waveform for transthoracic ventricular defibrillation. J Am Coll Cardiol 34:1595-1601,1999
Christini DJ, Stein KM, Markowitz SM, Mittal S, Slotwiner DJ, Lerman BB. The role of nonlinear dynamics in cardiac arrhythmia control. Heart Disease 1:190-200, 1999
Liu JE, Hahn RT, Stein KM, Markowitz SM, Okin PM, Devereux RB, Lerman BB. Left ventricular geometry and function preceding neurally-mediated syncope. Circulation 101:777-783, 2000
Mittal S, Ayati S, Stein KM, Schwartzman D, Cavlovich D, Tchou PJ, Markowitz SM, Slotwiner DJ, Scheiner MA, Lerman BB. Transthoracic cardioversion of atrial fibrillation: Comparison of rectilinear biphasic versus damped sine wave monophasic shocks. Circulation 101:1282-1287, 2000
Stein KM, Slotwiner DJ, Mittal S, Scheiner MA, Markowitz SM, Lerman BB. Formal analysis of the optimal duration of tilt testing for the diagnosis of neurally mediated syncope. Am Heart J 141: 282-288,2001
Mittal S, Das M, Stein KM, Markowitz SM, Slotwiner DJ, Scheiner MA, Iwai S, Lerman BB. Frequency of subacute resumption of isthmus conduction after ablation of atrial flutter. Am J Cardiol 87: 1113-1116, 2001
Christini DJ, Stein KM, Markowitz SM, Mittal S, Slotwiner DJ, Scheiner MA, Iwai S, Lerman BB. Nonlinear-dynamical arrhythmia control in humans. Proc Natl Acad Sci 98 5827-5832, 2001.
Christini DJ, Stein KM, Markowitz SM, Mittal S, Slotwiner DJ, Scheiner MA, Iwai S, Lerman BB. Complex AV-nodal dynamics during ventricular-triggered atrial pacing in humans. Am J Physiol 281: H865-H872, 2001.
Deale OC, Ng KT, Kim-Van Housen EJ, Lerman BB. Calibrated single-plunge bipolar electrode array for mapping myocardial vector fields in three dimensions during high-voltage transthoracic defibrillation. IEEE Trans Biomed Eng 48; 898-910, 2001
Lerman BB, Engelstein ED, Burkhoff D. Mechanelectrical feedback: Role of b-adrenergic receptor activation in mediating load-dependent shortening of ventricular action potential and refractoriness. Circulation 104: 486-490, 2001.
Mittal S, Hao SC, Iwai S, Stein KM, Markowitz SM, Slotwiner DJ, Lerman BB. Significance of inducible ventricular fibrillation in patients with coronary artery disease and unexplained syncope. J Am Coll Cardiol 38: 371-376, 2001.
Lerman BB, Ellenbogen KA, Kadish A, Platia E, Stein KM, Markowitz SM, Mittal S, Slotwiner DJ, Scheiner M, Iwai S, Belardinelli L, Jerling M, Shreeinwas R, Wolff AA. Electrophysiologic effects of a novel selective adenosine A1 agonist (CVT-510) on atrioventricular nodal conduction in humans. J Cardiovas Pharm & Therapy 6: 237-245, 2001.
Das MK, Stein KS, Canilang K, Markowitz SM, Mittal S, Slotwiner DJ, Iwai S, Lerman BB. Significance of sustained monomorphic ventricular tachycardia induced with short coupling intervals in patients with ischemic cardiomyopathy. Am J Cardiol 89: 987-990, 2002.
Mittal S, Lomnitz DJ, Mirchandani, Stein KM, Markowitz SM, Slotwiner DJ, Iwai S, Das MK, Lerman BB. Prognostic significance of nonsustained ventricular tachycardia after revascularization. J Cardiovasc Electrophysiol 13: 342-346, 2002.
Markowitz SM, Brodman RF, Stein KM, Mittal S, Slotwiner DJ, Iwai S, Das M, Lerman BB. Lesional Tachycardias related to mitral valve surgery. J Am Coll Cardiol 29: 1973-1983,2002.
Stein KS, Euler DE, Mehra R, Seidl K, Slotwiner DJ, Mittal S, Markowitz SM, Lerman BB. Do atrial tachyarrhythmias beget ventricular tachyarrhythmias in defibrillator patients? J Am Coll Cardiol 40: 335-340, 2002.
Stein KS, Markowitz SM, Mittal S, Slotwiner DJ, Iwai S, Lerman BB. Anatomic determinants of atrial arrhythmias: New insights from 3D mapping. Chaos 12:740-746, 2002.
Deale OC, Ng, KT, Kim-Van Housen EJ, Lerman BB. Simplified calibration of single-plunge bipolar electrode array for field measurement during defibrillation. IEEE Trans Biomed Eng 48:898-910, 2002.
Iwai S, Markowitz ,SM, Stein KM, Mittal S, SlotwinerDT, Das MK, Cohen JD, Hao S, Lerman BB.Response to adenosine differentiates focal from macroreentrant tachycardia: Validation using three-dimensional electroanatomic mapping. Circulation 106:2793-2799, 2002.
Slotwiner DJ, Christin DJ, Stein KM, Markowitz SM,Mittal S, Iwai S Das M, Cohen J, Hao S, Lerman BB. Muscle sympathetic nerve traffic during spontaneous vs. adenosine-mediated termination of right ventricular outflow tract tachycardia. Am J Cardiol 91:86-88, 2003.
Vaughan CJ, Hom Y, Okin DA, McDermott DA, Lerman BB, Basson CT. Molecular genetic analysis of PRKAG2 in sporadic Wolff-Parkinson-White syndrome. J Cardiovasc Electrophysiol 14: 263-268, 2003.
Scheinman M, Calkins H, Gillette P, Klein R, Lerman BB, Morady F, Saksena S, Waldo A. NASPE policy statement on catheter ablation: Personnel, procedures, and therapeutic recommendations. Pacing Clin Electophysiol 26: 789-800, 2003.
Christini DJ, Stein KM, Hao SC, Markowitz SM, Mittal SM, Slotwiner DJ, Iwai S, Das MK, Lerman BB. Endocardial detection of repolarization alternans. IEEE Trans Biomed Eng 50:855-862, 2003.
Blomstrom-Lundqvist C, Scheinman MM, Aliot ET, Slpert JS, Calkins H, Camm JA, Campbell WB, Haines DE, Kuck KH, Lerman BB, Miller DD, Schaeffer CW, Stevenson WG, Tomaselli GF. ACC/ AHA/ ESC Guidelines for management of patients with supraventricular arrhythmias. Circulation 108:1871-1909, 2003.
Cheung JW, Lerman BB. CVT-510: A selective A1 adenosine receptor agonist. Cardiovasc Drug Review 21:277-92, 2003.
Lerman BB, Basson CT. High-risk patients with ventricular preexcitation: A pendulum in motion N Engl J Med 349:1787-1789, 2003.
Mittal S, Stein KM, Markowitz SM, Iwai S, Guttigoli A, Lerman BB. A single-stage adenosine tilt test in patients with unexplained syncope. J Cardiovasc Electrophysiol 15:637-640, 2004.
Hao SC, Christini DJ, Stein KM. Jordan PW, Iwai S, Bramwell O, Markowitz SM, Mittal S, Lerman BB. Effect of beta adrenergic blockade on dynamic electrical restitution in vivo. Am J Physiol (Heart Circ Physiol) 287: H390-354, 2004.
Gerull B, Heuser A, Wichter T, Paul M, Basson CT, McDermott DA, Lerman BB, Markowitz SM, Ellinor PT, MacRae CA, Peters S, Grossmanns KS, Michely B, Sasse-Klaassen S, Birchmeier W, Dietx R, Breithardt G, Schulze-Bahr E, Thierfelder L. Mutations in the desmosomal protein plakophilin-2 are common arrhythmogenic right ventricular cardiomyopathy. Nature Genetics 36: 1162-1164, 2004.
Markowitz SM, Christini DJ, Stein KM, Mittal S, Iwai S, Slotwiner DJ, Lerman BB. Time course and predictors of autonomic dysfunction after ablation of the slow atrioventricular nodal pathway. PACE 27: 1-6, 2004.
Cheung JW, Stein KM, Markowitz SM, Iwai S, Guttigoli AB, Shah BK, Yarlagadda RK, Lerman BB, Mittal S. Significance of adenosine-induced atrioventricular block in patients with unexplained syncope. Heart Rhythm 1:664-668, 2004.
Guttigoli AB, Wilner BF, Stein KM, Markowitz SM, Iwai S, Shah BK, Yarlagadda RK, Lerman BB, Mittal S. Usefulness of prolonged QRS duration to identify high-risk ischemic cardiomyopathy patients with syncope and inducible ventricular tachycardia. Am J Cardiol 95:391-394, 2005.
Maybhate A, Hao SC, Iwai S, Lee JU, Guttigoli AB, Stein KM, Lerman BB, Christini DJ. Detection of repolarization alternans with an implantable cardioverter defibrillator lead in a porcine model. IEEE Biomed Eng 52:1187-1194, 2005
Morrison LJ, Dorian P, Long J, Vermeulen M, Schwartz B, Sawadsky B, Frank J, Cameron B, Burgess R, Shield J, Bagley P, Mausz V, Brewer JE, Lerman BB. Out-of hospital cardiac arrest rectilinear biphasic to monophasic damped sine defibrillation waveforms with advanced life support intervention trial (ORBIT). Resuscitation 66:49-157, 2005
Deale OC, Ng, KT, Lerman BB. Calibration current divider network for precision current delivery during high-voltage transthoracic defibrillation. IEEE Trans Biomed Eng 52:1970-1973, 2005.
Stein KM, Devereux RB, Hahn RT, Markowitz SM, Mittal S, Iwai S, Lerman BB. Depressant effects of transthoracic shocks on left ventricular function Resuscitation 66:309-315, 2005.
Yarlagadda R, Iwai S, Stein KM, Markowitz SM, Shah BK, Cheung J, Tan V, Lerman BB, Mittal S. Reversal of cardiomyopathy in patients with repetitive monomorphic ventricular ectopy originating from the right ventricular outflow tract. Circulation 112: 1092-1097, 2005.
Shah BK, Stein KM, Iwai S, Lerman BB. Pseudoblock and pseudoconduction across the cavotriscuspid isthmus. Heart Rhythm 2:750-753, 2005.
Cheung JW, Iwai S, Lerman BB, Mittal S. Shock-induced ventricular oversensing due to seal plug damage: a potential mechanism of inappropriate device therapies in implantable cardioveter defibrillators. Heart Rhythm 2:1371-1375, 2005.
Honors and Awards
- Clinical Cardiac Electrophysiology
- Catheter Ablation
- Cardiac Arrhythmia
- Implantable Defibrillators
- Abnormal Heart Rhythms
- Permanent Pacemakers
- Diagnostic Electrophysiology Study
- Ventricular Tachycardia
- Cardiac Resynchronization
- Clinical Electrophysiology
- Pacemaker Implant
- Radiofrequency Ablation
- Tilt Table Test
- Atrial Fibrillation
- Supraventricular Tachycardia
- Implant Cardiac Defibrillator
Contact and Practices
- Cardiovascular Disease
- Internal Medicine
- Clinical Cardiac Electrophysiology
- M.D., Stritch School of Medicine, Loyola University of Chicago, 1977