Makoto Ishii, M.D. Ph.D.
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Makoto Ishii, M.D. Ph.D.


Profile Photo of Makoto Ishii, M.D. Ph.D.
Accepts New Patients
Gender: Male
Language: English


Personal Statement

As a clinician scientist, Dr. Makoto Ishii believes that a two-pronged approach is essential in order to advance the medical care of patients with Alzheimer’s disease and related disorders.  First and foremost, patient care should be directed on a personal and individual basis based on the latest evidence-based medicine available.  Disorders like Alzheimer’s disease affect each individual and family differently and a comprehensive clinical management approach is often needed to provide the best possible care. However, in order to advance the treatment of these disorders, patient care must also be coupled with the latest research efforts.  By maintaining an active research laboratory, Dr. Ishii’s goal is to provide excellent patient care while also focusing on the ultimate goal of translating new research findings to the development of new diagnostic tools and novel therapies that can one day make a difference in the lives of the patients he sees.

Specialties and Expertise


  • Memory Disorder
  • Alzheimer's Disease
  • Dementia
  • Hypothalamus


Dr. Makoto Ishii is a board certified neurologist and a physician-scientist dedicated to both patient care and biomedical research focusing primarily on neurodegenerative and neuroendocrine disorders.  Dr. Ishii sees patients in the clinic as a member of the Alzheimer’s Disease & Memory Disorders Program at Weill Cornell Medicine.  He conducts his research primarily in the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine, where he is the head of a laboratory and the principal investigator for several ongoing studies on the role of body weight and neuroendocrine hormones in early Alzheimer’s disease.

Dr. Ishii earned his bachelor’s degree from Princeton University and is a graduate of the Tri-Institutional MD-PhD Program receiving his doctorate degree (PhD) from Rockefeller University and his medical degree (MD) from Weill Cornell Medical College.  He received his clinical training as a neurology resident at Weill Cornell Medical College, where he was also chief resident.  After his residency, Dr. Ishii received a Leon Levy Neuroscience Fellowship to conduct his initial research studies, which were the first to demonstrate that amyloid-beta, a major pathogenic factor in Alzheimer’s disease, can disrupt specific brain cells in the leptin pathway, an essential regulator of body weight, leading to body weight and metabolic deficits prior to any cognitive dysfunction.  Ongoing studies continue to elucidate the molecular mechanisms underlying the body weight and neuroendocrine deficits in Alzheimer’s disease.  Additional information regarding his research can be found at:

Based on these early achievements, Dr. Ishii was awarded the Paul B. Beeson Clinical Development Award in Aging, an extremely prestigious honor, where he joins past recipients who are currently top academic leaders in the field.  The Beeson Award is jointly supported by the National Institute on Aging (part of the NIH) and private foundations including the American Federation for Aging Research and The John A. Hartford Foundation.  In addition, Dr. Ishii’s laboratory is funded by an Alzheimer’s disease research grant from the Bright Focus Foundation.



Clinical and Academic Positions

  • Assistant Attending Neurologist - NewYork-Presbyterian Hospital
  • Assistant Professor of Neuroscience - Weill Cornell Medical College, Cornell University
  • Assistant Professor of Neurology - Weill Cornell Medical College, Cornell University

Education and Training

  • M.D., Weill Cornell Medical College, Cornell University, 2008
  • Ph.D., The Rockefeller University, 2004
  • B.S.E., Princeton University, 1998


Insurance Plans Accepted

The following represents most of the managed care plans accepted by this doctor. If your insurance carrier does not appear here please contact the doctor’s office as they may have individual contracts not included on this site.

* indicates this doctor is no longer accepting new patients with this insurance plan.

  • AETNA - Medicare
  • Aetna Weill Cornell Employee Managed Care Plan
  • Aetna Weill Cornell Employee PPO Plan
  • Aetna-NYP - EPO/POS
  • Affinity Access
  • Affinity Health Plan
  • Amida Care
  • Emblem Select Care
  • Empire Blue Cross/Blue Shield - Blue Access
  • Empire Blue Cross/Blue Shield - Blue Connection
  • Empire Blue Cross/Blue Shield - EPO
  • Empire Blue Cross/Blue Shield - HMO
  • Empire Blue Cross/Blue Shield - Mediblue (Senior)
  • Empire Blue Cross/Blue Shield - PPO
  • Empire Blue Cross/Blue Shield HealthPlus
  • Empire Blue Cross/Blue Shield HealthPlus - CHP
  • Fidelis Care
  • Health First
  • Health Insurance Plan of NY (HIP)
  • Health Insurance Plan of NY (HIP) - Medicaid
  • Health Insurance Plan of NY (HIP) - Medicare
  • Medicaid
  • Medicare
  • Oxford Health Plans - Freedom
  • Oxford Health Plans - Liberty
  • Oxford Health Plans - Medicare Advantage
  • Oxford Health Plans - Metro/Core/Charter
  • Rockefeller University - Trustmark
  • United Empire
  • United Healthcare
  • United Healthcare - Community Plan
  • United Healthcare - Medicare
  • United Healthcare Compass
  • VNSNY CHOICE - Medicare
  • WellCare of NY
  • WorldWide Medical

Locations and Appointments

External Relationships

External Relationships

Relationships and collaborations with for-profit and not-for profit organizations are of vital importance to our faculty because these exchanges of scientific information foster innovation. As experts in their fields, WCM physicians and scientists are sought after by many organizations to consult and educate. WCM and its faculty make this information available to the public, thus creating a transparent environment.

Other Interest:
Regeneron Pharmaceuticals, Inc.