Lionel B. Ivashkiv, M.D.
Rheumatology
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Lionel B. Ivashkiv, M.D.

Rheumatology

Profile Photo of Lionel B. Ivashkiv, M.D.
Gender: Male
Language: English

About

Specialties and Expertise

Specialties

  • Rheumatology

Expertise

  • Inflammatory Arthritis
  • APS (Antiphospholipid Syndrome)
  • Rheumatoid Arthritis
  • Bone Disease

Personal Statement

Our laboratory is interested in the differentiation, function, and activation of cells of the myeloid lineage that are important in innate immunity and autoimmune/inflammatory diseases. These cells include macrophages and dendritic cells (DCs) that activate immune/inflammatory responses and osteoclasts that mediate inflammatory bone loss (osteolysis). These cells are regulated by soluble proteins termed cytokines that trigger signal transduction and gene activation cascades. Recent breakthroughs in the treatment of autoimmune/inflammatory diseases have arisen from biological therapies that target myeloid cells and cytokines.

 

We study crosstalk among major myeloid cell signal transduction pathways, with an emphasis on the Janus kinase ᅡヨ signal transducer and activator of transcription (Jak-STAT) pathway that is utilized by many cytokines. We are delineating molecular mechanisms by which activating inputs from Jak-STAT, Toll-like receptor, and ITAM-dependent signaling pathways are integrated to activate cell effector functions. We study the functional relationships between signaling events and downstream effects on gene expression, cell function, and the severity of inflammation and related tissue damage. We are also interested in understanding how the production and function of homeostatic/suppressive cytokines (such as IL-10) are regulated. We are developing the idea that dynamic modulation or ᅡモreprogrammingᅡヤ of cytokine signaling during innate immunity and inflammation is an important determinant of the balance of cytokine action and the extent and nature of immune and inflammatory reactions.

 

The laboratory takes an integrated bench to bedside approach and studies signal transduction defects in defined in vitro systems using purified cells, in animal models of arthritis, lupus and osteolysis, and in human disease samples. Biochemical approaches are complemented by genetic approaches that utilize RNA interference or knockout mice, and by microarray analysis of genome-wide gene expression. The long term goals of our laboratory are to define the molecular basis of the regulation of cytokine signaling during innate immunity and inflammation, and to target signaling pathways as a novel approach to therapy.

Biography

Dr. Lionel B. Ivashkiv joined Hospital for Special Surgery staff in 1992. He combines clinical care of patients with arthritis and inflammatory diseases with basic research in inflammation and gene regulation. Dr. Ivashkiv serves as head of the Rheumatoid Arthritis Registry. He is the Director of the HSS Genomics Center which was established with a $5.6 million grant from The Tow Foundation to study rheumatoid athritis and lupus.

 

Research

Honors and Awards

Honors and Awards

1993   Arthritis Investigator Award

1995   Young Scholar Award, Arthritis Foundation, New York Chapter

1995   Jack Friedman Young Investigator Prize, Cornell University Medical College

2000   Department of Medicine Investigator Award, The New York Presbyterian Hospital

2001   Elected Member, American Society for Clinical Investigation

2004   Member, Henry Kunkel Society for Human Immunology

Credentials

Board Certifications

  • Internal Medicine
  • Rheumatology

Clinical and Academic Positions

  • Attending Physician - Hospital for Special Surgery
  • Professor of Medicine - Weill Cornell Medical College, Cornell University

Education and Training

  • M.D., Harvard Medical School, 1984

Insurance

Insurance Plans Accepted

For relevant information regarding accepted insurances, please contact this provider directly.

Locations and Appointments