K.S. Clifford Chao, M.D.
KS Clifford Chao, M.D., is a pre-eminent expert in the use of image-guided targeted radiotherapy and intensity modulated radiation therapy (IMRT) for the treatment of cancers, and is the Chairman of the Combined Program in Radiation Oncology at New York- Presbyterian Hospital, Weill Cornell Medical College and Columbia University Medical Center. Dr. Chao came to New York from The University of Texas M. D. Anderson Cancer Center in Houston, where he was a professor and the director of Image-Guided Therapy.
Before joining M. D. Anderson in 2002, Dr. Chao was an associate professor at Washington University School of Medicine in St. Louis. He received his medical degree from Kaohsiung Medical School in Taiwan. His postgraduate training included a Radiation Oncology residency and fellowship at Washington University School of Medicine and a surgical fellowship in the Cancer Research Institute in Tokyo, Japan.
In addition to serving as the Principle Investigator of multiple NIH research grants and publishing more than 100 peer-reviewed papers, he is the author of two widely read textbooks, “Management Decisions in Radiation Oncology” and “Practical Essentials of IMRT”. Dr. Chao’s research focus includes combining positron emission tomography (PET) and computed tomography (CT) images to construct individualized treatment plans that address the molecular characteristics of each tumor.
Dr. Chao’s clinical specialties include Head and Neck, Brain, Prostate, Digestive and Breast cancer.
Chao KSC, Lin FJ: Single and combined modality in the management of buccal cancer. Chin J Radiol 13:193-200; 1988.
Chao KSC: Intra arterial chemotherapy for malignant tumor of pelvis. J Taiwan Med Assoc 39:36-37; 1990.
Chao KSC, Lee S-T, Lin F-J, Tang SG, Leung W-M: A multivariate analysis of prognostic factors in management of pineal tumor. Int J Radiat Oncol Biol Phys 27:1185-1191; 1993.
Chao KSC, Grigsby PW, Perez CA, Camel MH, Kao MS, Galakatos AE, Boyle WA: Brachytherapy-related complications for medically inoperable stage I endometrial carcinoma. Int J Radiat Oncol Biol Phys 31(1):37-42; 1995.
Chao KSC, Lin H-S, Devineni VR, Smith ME: Radiation therapy for primary orbital lymphoma. Int J Radiat Oncol Biol Phys 31(4): 929-934; 1995.
Chao KSC, Gerber RM, Perez CA: Reirradiation of recurrent skin cancer of the face: A successful salvage modality. Cancer 75(9):2351-2355; 1995.
Chao KSC, Lai PL, Perez CA: Secondary malignancy among seminoma patients treated with adjuvant radiation therapy. Int J Radiat Oncol Biol Phys 33(4):831-835; 1995.
Chao KSC, Grigsby PW, Perez CA, Mutch DG, Herzog T, Camel HM: Medically inoperable stage I endometrial carcinoma: a few dilemmas in radiotherapeutic management. Int J Radiat Oncol Biol Phys 34(1):27-31; 1996.
Chao KSC, Emami B, Akhileswaran R, Simpson JR, Spector G, Sessions D: The impact of surgical margin status and interstitial implant on T1, T2 oral tongue cancers after surgery. Int J Radiat Oncol Biol Phys 35(5):1039-1043; 1996.
Perez CA, Grigsby PW, Chao KSC: Chemotherapy and irradiation in locally advanced squamous cell carcinoma of the uterine cervix: A review. Sem in Radiat Oncol 7(3, Suppl. 2):45-65; 1997.
Chao KSC, Low D, Gerber R, Perez CA, Purdy JA: Clinical and technical considerations for head and neck cancers treated by IMRT: Initial experience. Int J Radiat Oncol Biol Phys 39(2 Suppl):238; 1997.
Chao KSC, Williamson J, Grigsby PW, Perez CA: Uterosacral space involvement in locally advanced carcinoma of the uterine cervix. Int J Radiat Oncology Biol Phys 40(2):397-403; 1998.
Perez CA, Grigsby PW, Chao KSC, Williamson J, Lockett MA: Radiation therapy morbidity in carcinoma of the uterine cervix: dosimetric and clinical correlation. Cancer Journal 4(2):143; 1998.
Chao KSC, Leung W-M, Grigsby PW, Perez CA: The clinical implications of hydronephrosis and the level of ureteral obstruction in stage IIIB cervical cancer. Int J Radiat Oncol Biol Phys 40(5):1095-1100; 1998.
Perez CA, Grigsby PW, Chao KSC, Mutch DG, Lockett MA: Tumor size, irradiation, dose and long-term outcome of carcinoma of uterine cervix. Int J Radiat Oncol Biol Phys 41(2):307-317; 1998.
Perez CA, Grigsby PW, Chao KC, Galakatos A, Garipagaoglu M, Mutch D. Lockett MA: Irradiation in carcinoma of the vulva: Factors affecting outcome. Int J Radiat Oncol Biol Phys 42(2):335-344; 1998.
Low DA, Chao KSC, Mutic S, Gerber RL, Perez CA, Purdy JA: Quality assurance of serial tomotherapy for head and neck patient treatments. Int J Radiat Oncol Biol Phys 42(3):681-692; 1998.
Perez CA, Patel MM, Chao KSC, Simpson JR, Sessions D, Spector GJ, Haughey B, Lockett MA: Carcinoma of the tonsillar fossa: prognostic factors and long-term therapy outcome. Int J Radiat Oncol Biol Phys 42(5):1077-84; 1998.
Spector JG, Sessions DG, Chao KSC, Hanson JM, Simpson JR, Perez CA: Management of stage II (T2N0M0) glottic carcinoma by radiotherapy and conservation surgery. Head & Neck 21(2):116-123; 1999.
Perez CA, Grigsby PW, Lockett MA, Chao KSC, Williamson J: Radiation therapy morbidity in carcinoma of the uterine cervix: dosimetric and clinical correlation. Int J Radiat Oncol Biol Phys 44(4):855-866; 1999.
Grigsby PW, Perez CA, Chao KSC, Elbendary A, Herzog TJ, Rader JS, Mutch DG: Lack of effect of tumor size on the prognosis of carcinoma of the uterine cervix stage IB and IIA treated with preoperative irradiation and surgery. Int J Radiat Oncol Biol Phys 45(3);645-651; 1999.
Spector JG, Sessions DG, Chao KSC, Haughey BH, Hanson JM, Simpson JR, Perez CA: Stage I (T1N0M0) squamous cell carcinoma of the laryngeal glottis: therapeutic results and voice preservation. Head & Neck 21(8):707-717; 1999.
Chao KSC, Hsu JS, Xu J, Ezekiel UR, Eves E, Rosner M, Hsu CY: Differential effect of cycloheximide on neuronal and glioma cells treated with chemotherapy and radiation. J Neuro-Oncol 45:19-26; 1999.
Chao KSC, Low DA, Perez CA, Purdy JA: Intensity-modulated radiation therapy for head and neck cancers: The Mallinckrodt Experience. Int J Cancer 90:92-103; 1999.
Sessons DG, Spector GJ, Lenox J, Parriott S, Haughey B, Chao KSC, Marks J, Perez CA.: Analysis of treatment results for floor-of-mouth cancer. Laryngoscope 110: 1764-1772; 2000.
Chao KSC, Grigsby PW, Mutch D, Perez CA: Prognostic factors for distant metastasis in carcinoma of the cervix with endometrial extension. J Brachytherapy Int 16:181-186; 2000. (July-Sept)
Grigsby PW, Perez CA, Chao, KSC, Herzog T, Mutch D, Rader J: Radiation therapy for carcinoma of the cervix with positive para-aortic lymph nodes. Int J Radiat Oncol Biol Phys 49(3):733-738; 2001.
(March)Chao KSC, Deasy JO, Markman J, Haynie J, Perez CA, Purdy JA, Low DA: A prospective study of salivary function sparing in patients with head and neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results Int J Radiat Oncol Biol Phys 49(4):907-916; 2001.
Chao KSC, Bosch WR, Mutic S, Lewis JS, Dehdashti F, Mintun MA, Dempsey JF, Perez CA, Purdy JA, Welch MJ: A novel approach to overcome hypoxic tumor resistance – ATSM -guided intensity modulated radiation therapy Int J Radiat Oncol Biol Phys 49(4):1171-1182; 2001.
Grigsby PW, Williamson JF, Chao KSC, Perez CA: Cervical tumor control evaluated with ICRU 38 reference volumes and integrated reference air kerma. Radiother Oncol 58(1):19-23; 2001. (March)
Cheng JCH, Chao KSC, Low D: Comparison of IMRT treatment techniques for nasopharyngeal carcinoma. Int J Cancer 96(2):126-131; 2001. (April)
Low DA, Mutic S, Dempsey JF, Markman J, Chao KSC, Purdy JA: Abutment dosimetry for serial tomotherapy. Med Phys 26(1):79-82; 2001.
Spector JG, Sessions DG, Chao KSC, Simpson J, El Mofty S, Perez, CA: Delayed regional metastases, distant metastases and second primary malignancies in squamous cell carcinomas of the larynx and hypopharynx. Laryngoscope 111:1079-1087; 2001. (June)
Chao KSC, Kaplan C, Simpson JR, Haughey B, Spector GJ, Sessions DG, Arquette M: Esthesioneuroblastoma: The impact of treatment modality. Head and Neck 23(9):749-757; 2001. (August)
Huang R, Chao KSC, Tsai J, Simpson JR. Cancer of retromolar trigone: long-term radiation therapy outcome. Head and Neck 23(9):758-763; 2001. (August)
Christensen G, Carlson B, Chao KSC, Yin P, Grigsby PW, Nguyen K, Dempsey JF, Lerma FA, Bae KT, Vannier MW, Williamson JF: Image-based dose planning of intracavitary brachytherapy: registration of serial imaging studies using deformable anatomic templates. Int J Radiat Oncol Biol Phys 51(1):227-243; 2001. (Sept )
Mutic S, Dempsey JF, Bosch WR, Low DA, Drzymala RE, Chao KSC, Goddu SM, Cutler PD, Purdy JA: Multimodality image registration quality assurance for conformal three-dimensional treatment planning. Int J Radiat Oncol Biol Phys 51(1):255-260; 2001.
Portelance L, Chao KSC, Grigsby PW, Bennet H, Low D: Intensity modulated radiation therapy (IMRT) reduces small bowel, rectum, and bladder doses in patients with cervical cancer receiving pelvic and paraaortic irradiation. Int J Radiat Oncol Biol Phys 51(1):261-266; 2001.
Chao KSC, Majhail N, Huang C-J, Simpson JR, Perez CA, Haughey, B, Spector, G. Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: A comparison with conventional techniques. Radiotherapy & Oncology 61(3):275-280; 2001.
Deasy JO, Chao KSC, Markman J: Uncertainties in model-based outcome predictions for treatment planning. Int J Radiat Oncol Biol Phys 51(5):1389-99; 2001.
Michalski J, Purdy JA, Gaspar L, Souhami L, Ballow M, Bradley J, Chao KSC, Crane C, Eisbruch A, Fallowil D, Forster K, Fowler J, Gillin MT, Graham ML, Harms WB, Huq MS, Kline RW, Mackie TR, Mukherji S, Podogorsak EB, Roach M, Ryu J, Sandler H, Schultz CJ, Schell M, Verhey LJ, Vicini F, Winter KA; Radiation Therapy Oncology Group. Radiation Therapy Oncology Group. Research Plan 2002-2006. Image-Guided Radiation Therapy Committee. Int J Radiat Oncol Biol Phys. 2001;51(3 Suppl 2):60-5.
Greven KM, Levenback C, Chao KSC, Delaney T, Del Priore G, Eifel P, Erickson BA, Followill D, Gaffney D, Garcia M, Gerszten K, Grigsby P, Henderson R, Hricak H, Hsu J, Jhingrin A, Kaye A, Kudelka A, Lukka H, Mutch D, Nag S, Rotman M, Shefter T, Smith W, Stehman F, Souhami L, Wenzel L, Winter KA, Wolfson A; Radiation Therapy Oncology Group. Radiation Therapy Oncology Group. Research Plan 2002-2006. Gynecology Cancer Working Group. Int J Radiat Oncol Biol Phys 51(3 Suppl 2):58-9; 2001.
Zoberi, I, Wasserman, TH, Chao, KSC A prospective, nonrandomized study of the impact of amifostine on subsequent hypothyroidism in irradiated patients with head and neck cancers. Semin Radiat Oncol 12(1):14-17; 2002.
Low DA, Grigsby PW, Dempsey JF, Mutic S, Williamson JF, Markman J, Chao KSC, Klein EE, Purdy JA. Applicator-Guided Intensity Modulated Radiation Therapy. Int J Radiat Oncol Biol Phys 52(5), 2002.
Chao KSC. Protection of Salivary Function by Intensity Modulated Radiation Therapy in Patients with Head and Neck Cancer Semin Radiat Oncol 12(1):20-25, 2002.
Locke J, Low DA, Grigireit T, Chao KSC: Potential of tomotherapy for total scalp treatment. Int J Radiat Oncol Biol Phys 52(2):553-9, 2002.
Sessions DG, Lenox J, Haughey B, Chao KSC, Marks J: Analysis of treatment results for oral tongue cancer. Laryngoscope 112:616-625; 2002.(July 2001)
Ozyigit G , Chao KSC, Clinical experience of head-and-neck cancer IMRT with serial tomotherapy. Med Dosim 27(2):91-8; 2002.
Sessions DG, Lenox J, Spector GJ, Newland D, Simpson JR, Haughey BH, Chao KSC: Management of T3N0M0 Glottic Carcinoma: therapeutic outcomes. Laryngoscope 112:1281-1288; 2002.
Chao KSC, Wippold FJ, Ozyigit G, Tran BN, Dempsey JF: Determination and delineation of nodal target volumes for head and neck cancer based on the patterns of failure in patients receiving definitive and postoperative IMRT. Int J Radiat Oncol Biol Phys 53:1174-1184; 2002.
Chao KSC, Lin M: Lymphangiogram-Assisted Lymph Node Target Delineation For Patients With Gynecological Malignancies. Int J Radiat Oncol Biol Phys 54:1147-1152; 2002.
Perez CA, Bradley J, Chao KSC, Grigsby PW, Mutic S, Malyapa R. Functional imaging in treatment planning in radiation therapy: a review. Rays 27(3): 157-73, 2002.
Dai HS, Lin M, Hsu CY, Chao KSC: Inhibition of Hypoxia Inducible Factor 1α Causes Oxygen-Independent Cytotoxicity and Induces p53 Independent Apoptosis in Glioblastoma Cells. Int J Radiat Oncol Biol Phys 55:1027-1036, 2003.
Chao KSC, Blanco AI, Dempsey JF: A Target Coverage Scoring Function for Intensity Modulated Radiation Therapy (IMRT) Planning Based on the Probability of Gross Disease, Microscopic Tumor Extension and Lymph Node Metastasis. Int J Radiat Oncol Biol Phys 56:1438-1449, 2003.
Chao KSC, Ozyigit G, Tran BN, Dempsey JF, Low DA: Patterns of failure in patients receiving definitive and post-operative IMRT for head and neck cancer. Int J Radiat Oncol Biol Phys 55(2):312-321; 2003.
Weber RS, Berkey BA, Forastiere A, Cooper J, Maor M, Goepfert H, Morrison W, Glisson B, Trotti A, Ridge JA, Chao KS, Peters G, Lee DJ, Leaf A, Ensley J. Outcome of salvage total laryngectomy following organ preservation therapy: the Radiation Therapy Oncology Group trial 91-11. Arch Otolaryngol Head Neck Surg 129(1):44-9; 2003.
Sessions DG, Lenox J, Chao C, Chaudry OA: Analysis of treatment results for base of tongue cancer. Laryngoscope 113:1252-1261, 2003.
Chao KSC, Blanco AI, Dempsey JF. A conceptual model integrating spatial information to assess target volume coverage for IMRT treatment planning. Int J Radiat Oncol Biol Phys 56:1438-1449, 2003.
Barker J, Garden A, Dong L, O'Daniel J, Wang H, Court L, Morrison W, Rosenthal D, Chao C, Mohan R, Ang K. Radiation-induced anatomic changes during fractionated head & neck radiotherapy: a pilot study using an integrated CT-LINAC system. Int J Radiat Oncol Biol Phys. Oct 1;57(2 Suppl):304, 2003.
Hussussian CJ, Myckatyn T, Brenner MJ, Chao KSC, Hunter DA: The effects of external beam radiation in the rat tibial nerve following crush transection and repair, or nerve isograft paradigms. The Laryngoscope 114:931-938, 2003.
Gregoire V, Levendag P, Ang KK, Bernier J, Braaksma M, Budach V, Chao C, Coche E, Cooper JS, Cosnard G, Eisbruch A, El-Sayed S, Emami B, Grau C, Hamoir M, Lee N, Maingon P, Muller K, Reychler H: CT-based delineation of lymph node levels and related CTVs in the node-negative neck: DAHANCA, EORTC, GORTEC, NCIC, RTOG consensus guidelines. Radiotherapy and Oncology 69:227-236, 2003.
Barker JL, Glisson BS, Garden AS, El-Naggar AK, Morrison WH, Ang KK, Chao KSC, Clayman G, Rosenthal DI: Management of nonsinonasal neuroendocrine carcinomas of the head and neck. Cancer 98:2322-2328, 2003.
Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, Glisson B, Trotti A, Ridge JA, Chao C, Peters G, Lee DJ, Leaf A, Ensley J, Cooper J. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. New England Journal of Medicine 349(22):2091-8, 2003.
Thorstad WL, Haughey B, Chao KSC. Pilot study of subcutaneous amifostine in patients undergoing postoperative intensity modulated radiation therapy for head and neck cancer: preliminary data. Seminars in Oncology 30(6):96-100, 2003.
Chao KSC, Ozyigit G, Thorsdad WL, Toxicity profile of intensity-modulated radiation therapy for head and neck carcinoma and potential role of amifostine. Seminars in Oncology 30(6):101-108, 2003.
Thorstad WL, Chao KS, Haughey B: Toxicity and compliance of subcutaneous amifostine in patients undergoing postoperative intensity-modulated radiation therapy for head and neck cancer. Seminars in Oncology 31:8-12, 2004.
Chao KSC, Ozyigit G, Blanco AI, Thorstad WL, Deasy JO, Haughey BH, Spector JG, Sessions DG: Intensity-modulated radiation therapy for oropharyngeal carcinoma: Impact of tumor volume. Int J Radiat Oncol Biol Phys. 59:43-50, 2004.
Blanco AI, Chao KSC, Ozyigit G, Adli M, Thorstad WL, Simpson JR, Spector G, Haughey B, Perez CA: Carcinoma of paranasal sinuses: Long-term outcomes with radiotherapy. Int J Radiat Oncol Biol Phys. 59:51-58, 2004.
Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, Kish JA, Kim HE, Cmelak AJ, Rotman M, Machtay M, Ensley J, Chao KSC, Schultz CJ, Lee N, Fu KK, Postoperative Concurrent Radiation Therapy and Chemotherapy in High-Risk Squamous Cell Carcinoma of the Head & Neck: The RTOG 9501/Intergroup Phase III Trial. New England Journal of Medicine 350:1937-1944, 2004.
Garden AS, Morrison WH, Rosenthal DI, Chao KSC, Ang KK: Target coverage for head and Neck Cancer Treated with IMRT: Review of Clinical Experiences. Seminars in Radiation Oncology 14:103-109, 2004.
Myckatyn TM, Brenner M, Mackinnon SE, Chao KSC, Hunter DA, Hussussian CJ: Effects of external beam radiation in the rat tibial nerve after crush, transection and repair, or nerve isograft paradigms. Laryngoscope 114:931-938, 2004.
Barker JL, Garden AS, Ang KK, O’Daniel JC, Wang H, Court LE, Morrison WH, Rosenthal DI, Chao KSC, Tucker SL, Mohan R, Dong L: Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for head and neck cancer using an integrated CT/Linear accelerator system. International Journal of Radiation Oncology, Biology, and Physics 59:960-970, 2004.
Rosenthal D, Barker JL, El-Naggar AK, Glisson BS, Kies MS, Diaz EM, Clayman GL, Demonte F, Selek U, Morrison WH, Ang KK, Chao KSC, Garden AS. Sinonasal malignancies with neuroendocrine differentiation: patterns of failure according to histologic phenotype. Cancer. 101(11):2567-73, 2004.
Apisarnthanarax S, Chao KSC: Current imaging paradigms in radiation oncology. Radiation Research 163(1):1-25, 2005.
Chambers MS, Garden AS, Rosenthal D, Ahamad A, Schwartz DL, Blanco AI, Chao KS, Morrison WH, Ang KK, Weber RS: Intensity-Modulated Radiotherapy: Is Xerostomia Still Prevalent? Current Oncology Reports 7:131-136, 2005.
Blanco AI, Chao KSC, El Naga I, Franklin GE, Zakarian K, Vicic M, Deasy JO. Dose-volume modeling of salivary function in patients with head-and-neck cancer receiving radiotherapy. Int J Radiat Oncol Biol Phys. 62(4):1055-69, 2005.
Frank SJ, Chao KSC, Schwartz DL, Weber RS, Apisarnthanarax S, Macapinlac HA. PET and PET/CT in head and neck tumor staging and radiation therapy planning. Nature Clinical Practice Oncology, 2(10): 526-533, 2005.
Apisarnthanarax S, Elliott DD, El Naggar AK, Asper JA, Blanco A, Ang KK, Garden AS, Morrison WH, Rosenthal DI, Weber RS, Chao KSC, Determining Optimal Clinical Target Volume Margins in Head and Neck Cancer Based on Microscopic Extracapsular Extension of Metastatic Neck Nodes. Int J Radiat Oncol Biol Phys. 64(2):678-683, 2006.
Izzo JG, Malhotra U, Wu TT, Ensor J, Luthra R, Lee JH, Swisher SG, Liao Z, Chao KSC, Hittelman WN, Aggarwal BB, Ajani JA. Association of Activated Transcription Factor Nuclear Factor KB With Chemoradiation Resistance and Poor Outcome in Esophageal Carcinoma. Journal of Clinical Oncology, 24(5):748-754, 2006.
Rosenthal DI, Asper JA, Blanco A, Ang KK, Garden AS, Chao KSC, Morrison WH, Weber RS, The Importance of a Quality Assurance Program in Head and Neck Radiation Oncology that Includes Patient Examination. Head and Neck 28(11):967-973, 2006.
Apisarnthanarax S, Alauddin MM, Mourtada F, Ariga H, Raju U, Mawlawi O, Han D, Bornmann WG, Ajani JA, Milas L, Gelovani JG, Chao KSC. Early Detection of Chemoradioresponse in Esophageal Carcinoma by 3'-Deoxy-3'-18F-Fluorothymidine Using Preclinical Tumor Models. Clinical Cancer Research 12(15):4590-7, 2006.
Yuan H, Yu Y, Chao KSC, Fu Z, Yin Y, Guo H, Yu JM. The Additional Value of FDG PET/CT over PET in the Assessment Loco-regional Lymph Nodes of the Thoracic Esophageal Squamous Cell Cancer. Journal of Nuclear Medicine 47(8):1255-1259, 2006.
Sims-Mourtada J, Izzo JG, Apisarnthanarax S, Malhotra U, Wu TT, Luthra R, Liao Z, Komaki R, van de Kogel A, Ajani JA, Chao KSC. Hedgehog: an attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation response. Clinical Cancer Research 12(21):6565-6572, 2006.
Tatum JL, Kelloff GJ, Gillies RJ, Arbeit JM, Brown JM, Chao KSC, Chapman JD, Eckelman WC, Fyles AW, Giaccia AJ, Hill RP, Koch CJ, Krishna MC, Krohn KA, Lewis JS, Mason RP, Melillo G, Padhani AR, Powis G, Rajendran JG, Reba R, Robinson SP, Semenza GL, Swartz HM, Vaupel P, Yang D, Croft B, Hoffman J, Liu G, Stone H, Sullivan D. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol. 82(10):699-757, 2006.
Kuo YC, Wu TH, Chung TS, Huang KW, Chao KSC, Su WC, Chiou JF Effect of regression of enlarged neck lymph nodes on radiation doses received by parotid glands during intensity-modulated radiotherapy for head and neck cancer. Am J Clin Oncol 29(6):600-605, 2006
Izzo JG, Wu TT, Wu X, Ensor J, Patel BB, Pan J. Correa A, Swisher SG, Chao KSC, Hittelman WN, Ajani JA. Correlation of Pre-treatment Nuclear NF-kB Status with Chemoradiation Resistance and Metastatic Progression Irrespective of the Type of Chemotherapy Used with Radiation for Esophageal Carcinoma. Molecular Cancer Therapeutics 5(11):2844-2850, 2006.
Izzo JG, Luthra R, Malhotra U, Wu TT, Hung MC, Chao KSC, Aggarwal BB, Hittelman WN, Ajani JA. Molecular Mechanisms in Barrett’s Metaplasia and its Progression. Seminar in Oncology 34(2 Suppl 1):S2-6, 2007
Izzo JG, Wu TT, Wu X, Ensor J, Patel BB, Pan J. Correa A, Swisher SG, Chao KSC, Hittelman WN, Ajani JA. Association of Cyclin D1 Genotype with Altered Cyclin D1 Expression, Increased Genomic Instability, Early Age at Diagnosis and Poor Outcome for Esophageal Adenocarcinoma Patients. Journal of Clinical Oncology 25(6):698-707, 2007.
Yuan H, Meng X, Mu D, Yu JM, Chao KSC, Zhang J, Zhong W, Yu Y, Wang J, Sun X, Yang G, Wang Y. . Determining Optimal Clinical Target Volume Margins In Non-Small Cell Cancer Based On Microscopic Extracapsular Extension Of Metastatic Nodes. Int J Radiat Oncol Biol Phys. 67(3):727-34, 2007
Azhdarinia A, Yang D, Chao KSC, Mourta F. Infrared-based module for 68Ga-labeled radiotracers synthesis. Nuclear Medicine and Biology 34(1):121-7, 2007.
Chang EL, Akyurek S, T. Avalos, N. Rebueno, C. Spicer, J. Garcia, R. Famiglietti, P. Allen, Chao KSC, A. Mahajan. Evaluation of peritumoral edema in the delineation of radiotherapy clinical target volumes for glioblastoma. Int J Radiat Oncol Biol Phys. 68(1):144-150, 2007
Sims-Mourtada J, Izzo JG, Ajani JA, Chen H, Ensor J, Wu TT, Luthra R, Liao Z, Komaki R, Swisher SG, Chao KSC. Hedgehog signaling mitigates chemotherapeutic response by upregulation of multidrug resistance proteins. Oncogene 26(38):5674-5679, 2007.
Chen YJ, Sims-Mourtada J, Izzo JG, Chao KSC. Targeting the Hedgehog Pathway to mitigate treatment resistance. Cell Cycle 6(15):1826-1830.2007
Chao KSC, Bhide S, Chen H, Asper J, Bush S, Franklin G, Kavadi V,. Liengswangwong, W. Gordon, A. Raben, Zhang L, Dong L. Reduce in variation and improve efficiency of target volume delineation by a computer-assisted system using a deformable image registration approach. Int J Radiat Oncol Biol Phys. 68(5):1512-1521, 2007
Wang KL, Yang YC, Chao KSC, Wu MH, Tai HC, Chen TC, Huang MC, Chen JR, Su TH, Chen YJ. Correlation of traditional point A with anatomic location of uterine artery and ureter in cancer of the uterine cervix. Int J Radiat Oncol Biol Phys. 69(2):498-503, 2007.
Izzo JG, Malhotra U, Wu TT, Luthra R, Correa AM, Swisher SG, Hofstetter W, Chao KSC, Hung MC, Ajani JA. Clinical biology of esophageal adenocarcinoma after surgery is influenced by nuclear factor-kappaB expression. Cancer Epidemiol Biomarkers Prev. 16(6):1200-5, 2007.
Petsuksiri J, Frank SJ, Garden AS, Ang KK, Morrison WH, Chao KSC, Rosenthal DI, Schwartz DL, Ahamad A, Esmaeli B. Outcomes after radiotherapy for squamous cell carcinoma of the eyelid. Cancer. 112(1):111-118, 2008.
Li H, Zhu XR, Zhang L, Dong L, Tung S, Ahamad A, Chao KSC, Morrison WH, Rosenthal DI, Schwartz DL, Mohan R, Garden AS. Comparison of 2D radiographic images and 3D cone beam computed tomography for positioning head-and-neck radiotherapy patients. Int J Radiat Oncol Biol Phys. 71(3):916-25, 2008.
Lin CC, Wang TE, Liu CY, Lin CP, Liu TP, Chen MJ, Chang WH, Lin JC, Chang KM, Chu CH, Shih SC, Chao KSC, Chen YJ. Potentiation of the immunotherapeutic effect of autologous dendritic cells by pretreating hepatocellular carcinoma with low-dose radiation. Clin Invest Med. 31(3):150-9, 2008.
Moeller BJ, Rana V, Chao KSC, Schwartz DL. Prospective risk-adjusted [18F]Fluorodeoxyglucose positron emission tomography and computed tomography assessment of radiation response in head and neck cancer. Journal of Clinical Oncology 2009; 7(15): 2509-2515.
Tai HC, Hsieh CH, Chao KSC, Liu SH, Leu YS, Chang YF, Hsiao HT, Chang YC, Huang DY, Chen YJ. Comparison of radiotherapy strategies for locally advanced hypopharyngeal cancer after resection and ileocolic flap reconstruction. Acta Otolaryngol. 2009;129(3):311-7.
Yang YC, Chao KS, Lin CP, Chen YY, Wang KL, Chen YJ. Oxaliplatin regulates DNA repair responding to ionizing radiation and enhances radiosensitivity of human cervical cancer cells. Int J Gynecol Cancer 2009;19(4):782-6.
Chen YJ, Chao KSC, Yang YC, Hsu ML, Lin CP, Chen YY. Zoledronic acid, an aminobisphosphonate, modulates differentiation and maturation of human dendritic cells. Immunopharmacol and Immunotoxicol 2009;31(3): 499–508.
Tai HC, Hsieh CH, Chao KS, Liu SH, Leu YS, Chang YF, Hsiao HT, Chang YC, Huang DY, Chen YJ. Acta Otolaryngol. Comparison of radiotherapy strategies for locally advanced hypopharyngeal cancer after resection and ileocolic flap reconstruction. 2009 Mar;129(3):311-7.
McGovern SL, Williams MD, Weber RS, Sabichi A, Chambers MS, Martin JW, Chao KSC. Three synchronous HPV-associated squamous cell carcinomas of Waldeyer's ring: Case report and comparison with Slaughter's model of field cancerization. Head Neck. 2010 Aug;32(8):1118-24.
Moeller BJ, Rana V, Cannon BA, Williams MD, Sturgis EM, Ginsberg LE, Macapinlac HA, Lee JJ, Ang KK, Chao KS, Chronowski GM, Frank SF, Morrison WH, Rosenthal DI, Weber RS, Garden AS, Lippman SM, Schwartz DL. Prospective imaging assessment of mortality risk after head-and-neck radiotherapy. Int J Radiat Oncol Biol Phys. 2010 Nov 1;78(3):667-74.
Deasy JO, Moiseenko V, Marks L, Chao KS, Nam J, Eisbruch A. Radiotherapy dose-volume effects on salivary gland function. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S58-63. Review.
Frank SJ, Rosenthal DI, Petsuksiri J, Ang KK, Morrison WH, Weber RS, Glisson BS, Chao KS, Schwartz DL, Chronowski GM, El-Naggar AK, Garden AS. Intensity-modulated radiotherapy for cervical node squamous cell carcinoma metastases from unknown head-and-neck primary site: M.D. Anderson Cancer Center outcomes and patterns of failure. Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):1005-10. Epub 2010 Mar 6.
Wernicke AG, Parashar B, Kulidzhanov F, Riley L., Christos PJ, Fischer A, Nori D, Chao KS. Prospective study validating inter- and intraobserver variability of tissue compliance meter in breast tissue of healthy volunteers: Potential implications for patients with radiation-induced fibrosis of the breast. Int J Radiat Oncol Biol Phys. 2010 Apr 13.
Parashar B, Edwards A, Mehta, R, Pasmantier M, Wernicke AG, Sabbas A, Kerestez RS, Nori D, Chao KS. Chemotherapy significantly increases the risk of radiation pneumonitis in radiation therapy of advanced lung cancer. Am J Clin Oncol. 2010 May 21.
Parashar B, Patel P, Monni S, Singh P, Sood N, Trichter S, Sabbas A, Wernicke AG, Nori D, Chao KS. Limited resection followed by intraoperative seed implantation is comparable to stereotactic body radiotherapy for solitary lung cancer. Cancer. 2010 Nov 1;116(21):5047-53.
Wernicke AG, Goodman RL, Turner BC, Komarnicky LT, Curran WJ, Christos PJ, Khan I, Vandris K, Parashar B, Nori D, Chao KS. A 10-year follow-up of treatment outcomes in patients with early stage breast cancer and clinically negative axillary nodes treated with tangential breast irradiation following sentinel lymph node dissection or axillary clearance. Breast Cancer Res Treat. Breast Cancer Res Treat. 2011 Feb;125(3):893-902.
Patel PS, Yan W, Trichter S, Sabbas A, Rosenblatt R, Drotman MB, Swistel A, Chao KS, Nori D, Hayes MK. Seroma is an expected consequence and not a complication of MammoSite brachytherapy. Breast J. 2011 Sep-Oct;17(5):498-502. doi: 10.1111/j.1524-4741.2011.01127.x.
Parashar B, Wernicke AG, Pavese A, Singh P, Trichter S, Sabbas A, Kutler DI, Kuhel W, Port JL, Lee PC, Nori D, Chao KS. Cesium-131 permanent seed brachytherapy: dosimetric evaluation and radiation exposure to surgeons, radiation oncologists, and staff. Brachytherapy 2011 Nov;10(6):508-13. doi: 10.1016/j.brachy.2011.04.002.
Parashar B, Patel P, Singh P, Monni S, Trichter S, Sabbas A, Wernicke AG, Nori D, Chao KS. Management of Single Malignant Lung Nodules in Elderly Patients (70 Years or Older) Who are Not Candidates for Lobectomy. Am J Clin Oncol. 2011 May 6.
Chen YJ, Lin CP, Hsu ML, Shieh HR, Chao NK, Chao KS. Sonic hedgehog signaling protects human hepatocellular carcinoma cells against ionizing radiation in an autocrine manner. Int J Radiat Oncol Biol Phys. 2011 Jul 1;80(3):851-9. Epub 2011 Mar 4.
Parashar B, Edwards A, Mehta R, Pasmantier M, Wernicke AG, Sabbas A, Kerestez RS, Nori D, Chao KS. Chemotherapy significantly increases the risk of radiation pneumonitis in radiation therapy of advanced lung cancer. Am J Clin Oncol. 2011 Apr;34(2):160-4.
Wernicke AG, Parashar B, Kulidzhanov F, Riley L, Christos PJ, Fischer A, Nori D, Chao KS. Prospective study validating inter- and intraobserver variability of tissue compliance meter in breast tissue of healthy volunteers: potential implications for patients with radiation-induced fibrosis of the breast. Int J Radiat Oncol Biol Phys. 2011 May 1;80(1):39-46.
Sharma C, Deutsch I, Lewin SN, Burke WM, Qiao Y, Sun X, Chao KS , Herzog TJ, Wright JD. Lymphadenectomy influences the utilization of adjuvant radiation treatment for endometrial cancer. Am J Obstet Gynecol. 2011 Dec;205(6):562.e1-9.
Sharma C, Deutsch I, Horowitz DP, Hershman DL, Lewin SN, Lu YS, Neugut AI, Herzog TJ, Chao KS, Wright JD. Patterns of care and treatment outcomes for elderly women with cervical cancer. 2011 Oct 28. doi: 10.1002/cncr.26589.
Chen YJ, Kuo CD, Chen SH, Chen WJ, Huang WC, Chao KS, Liao HF Small-molecule synthetic compound norcantharidin reverses multi-drug resistance y regulating Sonic hedgehog signaling in human breast cancer cells. PLoS on. 2012 Epub 2012 May 15. PMID:22615870.
Li B, Chen M, Nori D, Chao KS, Chen AM, Chen SL Adjuvant Radiation Therapy and Survival for Pure Tubular Breast Carcinoma-Experience From the SEER Database. Int J Radiat Oncol Biol Phys. 2012 Sep PMID: 22543207.
Liao HF, Su YC, Zheng ZY, Jhih Cai C, Hou MH, Chao KS, Chen YJ. Sonic hedgehog signaling regulates Bcr-Abl expression in human chronic myeloid leukemia cells. Biomed Pharmacother. 66(5):378-83, 2012. PMID:22397755.
Yan W, Christos P, Nori D, Chao KS, Ravi A. Is There a Cause-specific Survival Benefit of Postmastectomy Radiation Therapy in Women Younger Than Age 50 With T3N0 Invasive Breast Cancer? A SEER Database Analysis: Outcomes by Receptor Satus/Race/Age : Analysis Using the NCI Surveillance, Epidemiology, and End Result (SEER) Database. Am J Clin Oncol. 2012 Aug 2 PMID: 22868241.
Parashar B, Wernicke AG, Rice S, Osborne J, Singh P, Nori D, Vallabhajosula S, Goldmith S, Chao, K.S. Early assessment of radiation response using a novel functional imaging modality – [18F]fluorocholine PET (F-PET): a pilot study. Discov Med 2012 Jul;14(74): 13-20 PMID: 22868241.
Yan P, Cheeseborough JC 3rd., Chao KS Automatic Shape-Based Level Set Segmentation for Needle Tracking in 3-D TRUS-Guided Prostate Brachytherapy. Ultrasound Med Biol. 2012 Sep;38(9):1626-36 PMID:22763006.
Yu-Chieh Su, Szu-Chin Li,Yin-Chi Wu,Li-Min Wang, K S Clifford Chao, and Hui-Fen Liao Resveratrol Downregulates Interleukin-6-Stimulated Sonic Hedgehog Signaling in Human Acute Myeloid Leukemia. Evidence Based Complementary and Alternative Medicine, vol. 2013 Article ID 547430, 2013.
Honors and Awards
Best Doctors in America, 2004-2012
Chu H. Chang Distinguished Professor, Columbia University College of Physicians and Surgeons, 2008
Keynote Speaker of 2009 Asian Pacific Head and Neck Oncology Congress, Taipei, Taiwan, September 18, 2009
Keynote Speaker of 2008 International Symposium on Cancer Nanotechnology and Image-guided Therapy, Taipei, Taiwan, December 25, 2008
Keynote Speaker of 2006 Taiwan Radiology Society meeting, Kaohsiung, Taiwan, March 26, 2006
Keynote Speaker of 2006 International Society of Gastroenterology Oncology ICACT/ISGIO meeting, Paris, France, February 1, 2006
Annual Oration in Radiation Oncology, Radiological Society of North America (RSNA) Chicago, Illinois, November 30, 2005
Keynote Speaker of 8th Japan 3-D CRT Symposium, Ciba, Japan, July 25, 2003
Richard Evan Memorial Lecture at University of Kansas. February 14, 2003
ASTRO/ESTRO Travel Award Oct. 1997
Essay Award - Gilbert H. Fletcher Society, Nineteenth Annual Meeting of the Gilbert H. Fletcher Society, Houston, Texas, April 7-9, 1994
Essay Award - American Brachytherapy Society, Sixteenth Annual Meeting of the American Brachytherapy Society, Scottsdale, Arizona December 8-11, 1993
Best Intern of the Year, Chang-Gung Memorial Hospital, 1982
President, Medical Student Association, Kaohsiung Medical School, 1981
Head, Aboriginal Area Medical Service Corporation, Kaohsiung Medical School, 1980
- Radiation Oncology
- Breast Cancer
- Prostate Cancer
- Gastrointestinal Cancer
- Brain Cancer
- Esophageal Cancer
- Radiation Therapy
- Pancreatic Cancer
- Head and Neck Cancer
- Radiation Oncology
- M.D., Kaohsiung Medical College (Taiwan), 1982