George S. Alexopoulos, M.D.

George Alexopoulos

George S. Alexopoulos, MD received his Doctor of Medicine degree from the National University of Athens in Athens, Greece. He had his Psychiatry residency at New Jersey Medical School of the New Jersey College of Medicine and Dentistry and at Cornell University Medical College, where he also had his research fellowship in psychobiology.

Dr. Alexopoulos has published more than 350 articles and book chapters on the psychobiology of geriatric mood disorders and on effectiveness and services research. He founded the Weill-Cornell Institute of Geriatric Psychiatry in 1994 and still serves as its Director. Dr. Alexopoulos is also the Director of the NIMH-supported Advanced Center for Interventions and Services Research in Late-Life Depression. Present appointments held by G. Alexopoulos, MD at Weill Medical College of Cornell University include Professor of Psychiatry, Professor of the Graduate School of Medical Sciences, Vice Chairman for Geriatric Psychiatry, and Co-Director of the Aging Center for Research and Clinical Care.

Dr. Alexopoulos has received the Senior Investigator’s Award of the International College of Geriatric Psychopharmacology, the Jack Weinberg Memorial Award, American Psychiatric Association, the Geriatric Research Award by the American College of Psychiatrists, the Joseph Zubin Research Award of the American Psychopathological Association, the Distinguished Psychiatrist Lecturer Award of the American Psychiatry Association, and the Senior Investigator's Award of the American Association for Geriatric Psychiatry. He has served on the Board of Scientific Counselors of the National Institute of Mental Health, the National Depressive and Manic Depressive Association and several other organizations. Dr. Alexopoulos is the Editor for Western Hemisphere and Japan, International Journal of Geriatric Psychiatry, and is on the editorial board of several other professional journals.

Email: Weill Institute of Geriatric Psychiatry


*** Please note, Dr. Alexopoulos is currently not accepting new patients.
For patient referral:
  Call - 1 (888) 694-2255


Insurance Plans Accepted

The following represents most of the managed care plans accepted by this physician. If your insurance carrier does not appear here please contact the physician’s office as they may have individual contracts not included on this site.

* indicates this physician is no longer accepting new patients with this insurance plan.

  • Aetna - Weill Cornell [POS]
  • Medicare
  • Rockefeller University - CoreSource



Alexopoulos, G.S., Vrontou, C., Kakuma, T., Meyers, B.S., Young, R.C., Klausner, E., Clarkin, J. "Disability in Geriatric Depression." Am J Psychiatry vol.153 (1996): 877-885.   

Alexopoulos, G.S., Meyers, B.S., Young, R.C., Campbell, S., Sibersweig, D., Charlson, M. "The 'Vascular Depression' Hypothesis." Arch Gen Psychiatry vol.54 (1997): 915-922.

Alexopoulos, G.S., Meyers, B.S., Young, R.C., Kakuma, T., Silbersweig, D., Charlson, M. "Clinically Defined Vascular Depression." Am J Psychiatry vol.154 (1997): 562-565.

Alexopoulos, G.S., Bruce, M.L., Hull, J., Kakuma, T. "Clinical Determinants of Suicidal Ideation and Behavior in Geriatric Depression." Arch Gen Psychiatry vol.56 (1999): 1048-1053.

Alexopoulos GS, Raue P, Arean P: Problem-solving therapy in geriatric depression with executive dysfunction. Am J Geriatr Psychiatry 11:46-52, 2003.

Alexopoulos GS: On the "infallibility" of sciences of psychopathology and its implications for action. Am J Psychiatry 161:2151-2154, 2004.

Alexopoulos GS, Streim J, Carpenter D, Docherty JP: The Expert Consensus Guideline Series: Using Antipsychotic Agents in Older Patients. J Clin Psychiatry 65 (suppl 2): 1-105, 2004.

Bruce ML, Ten Have TR, Reynolds III CF, Katz IR, Schulberg HC, Mulsant BH, Brown GK, McAvay GJ, Pearson JL, Alexopoulos GS: Reducing suicidal Ideation and depressive symptoms In depressed older primary care patients. A randomized controlled trial. JAMA 291:1081-1091, 2004.

Alexopoulos GS, Kiosses DN, Murphy C, Heo M: Executive dysfunction, heart disease burden, and remission of geriatric depression. Neuropsychopharmacol 29: 2278-2284, 2004.

Alexopoulos GS, Katz IR, Bruce ML, Heo M, Have TT, Raue P, Bogner HR, Schulberg HC, Mulsant BH, Reynolds CF 3rd.: Remission in Depressed Geriatric Primary Care Patients: A Report From the PROSPECT Study. Am J Psychiatry 162:718-724, 2005.

Alexopoulos GS:  Depression in the elderly. Lancet 365:1961-70, 2005.

Alexopoulos GS, Kiosses N, Heo M, Murphy CF, Shanmugham B, Gunning-Dixon F: Executive dysfunction and the course of geriatric depression. Biol Psychiatry 58:204-210, 2005.

Alexopoulos GS, Sirey J, Raue PJ, Kanellopoulos D, Clark TE, Novitch RS: Outcomes of depressed patients undergoing inpatient pulmonary rehabilitation. Am J Geriatr Psychiatry 14:466-475, 2006.

Barnes DE, Alexopoulos GS, Lopez OL, Williamson JD, Yaffe K: Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the cardiovascular health study. Arch Gen Psychiatry 63:273-279, 2006.

Alexopoulos GS, Murphy CF, Gunning-Dixon FM, Kalayam B, Katz R, Kanellopoulos D, Etwaroo GR, Klimstra S, Foxe JJ: Event-related potentials in an emotional go/no-go task and remission of geriatric depression. Neuroreport 18:217-21, 2007.

Alexopoulos GS, Kanellopoulos D, Murphy C, Gunning-Dixon F, Katz R, Heo M: Placebo response and antidepressant response. Am J Geriatr Psychiatry 15:149-58, 2007.

Alexopoulos GS, Murphy CF, Gunning-Dixon FM, Latoussakis V, Kanellopoulos D, Klimstra S, Lim KO, Hoptman MJ:  Microstructural white matter abnormalities and remission of geriatric depression.  Am J Psychiatry 165(2):238-44, 2008.

Alexopoulos GS, Murphy CF, Gunning-Dixon FM, Glatt CE, Latoussakis V, Kelly RE Jr, Kanellopoulos D, Klimstra S, Lim KO, Young RC, Hoptman MJ:  Serotonin transporter polymorphisms, microstructural white matter abnormalities and remission of geriatric depression. J Affect Disord 119:132-141, 2009.
Alexopoulos GS, Glatt CE, Hoptman MJ, Kanellopoulos D, Murphy CF, Kelly RE Jr, Morimoto SS, Lim KO, Gunning FM: BDNF Val66met polymorphism, white matter abnormalities and remission of geriatric depression. J Affect Disord Sep;125(1-3):262-8, 2010.
Alexopoulos GS, Morimoto SS: The inflammation hypothesis in geriatric depression. Int J Geriatr Psychiatry 26:1109-18, 2011.
Alexopoulos GS, Raue PJ, Kiosses DN, Mackin RS, Kanellopoulos D, McCulloch C, Arean PA: Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction: Effect on disability. Arch Gen Psychiatry, Jan 68(1):33-41, 2011.
Alexopoulos GS, Hoptman MJ, Kanellopoulos D, Murphy CF, Lim KO, Gunning FM: Functional connectivity in the cognitive control network and the default mode network in late-life depression. J Affect Disord, 139(1):56-65, 2012.



Honors and Awards

Senior Investigator's Award of the American Association of Geriatric Psychiatry, 1997

Distinguished Psychiatrist Lecturer Award by the American Psychiatric Association, 2002

Fellow of the American College of Psychiatrists as of 2004

The Joseph Zubin Research Award of the American Psychopathological Association, 2004

Award for Research in Geriatric Psychiatry, American College of Psychiatrists, 2006

Best Doctors in New York 2001, 2002, 2005 and 2006

Member of the NIMH Board of Scientific Counselors, 2001-2006

Jack Weinberg Memorial Award, American Psychiatric Association, 2008