Daniel M. Knowles, M.D.

Anatomic Pathology and Clinical Pathology
Daniel Knowles

Dr. Daniel Knowles serves as the David D. Thompson Professor and Chairman of Pathology of the Weill Medical College of Cornell University and as Pathologist-in-Chief at New York-Presbyterian Hospital. Dr. Knowles is internationally recognized for his diagnostic expertise and for his many scholarly accomplishments in hematopathology. He received his MD from the University of Chicago Pritzker School of Medicine, completed residency in pathology at the Columbia University College of Physicians and Surgeons, and received scientific training at the Rockefeller University. Dr. Knowles served as Chief of Surgical Pathology at the Columbia University College of Physicians and Surgeons before coming to the Weill Medical College. He has published more than 275 scientific papers, primarily in hematopathology, is a member of the International Lymphoma Study Group, is the editor of the leading hematopathology textbook, Neoplastic Hematopathology, directs the annual Tutorial on Neoplastic Hematopathology, and is a member of more than 15 Editorial Boards. Dr. Knowles is listed in "Best Doctors in America."


Insurance Plans Accepted

The following represents most of the managed care plans accepted by this physician. If your insurance carrier does not appear here please contact the physician’s office as they may have individual contracts not included on this site.

* indicates this physician is no longer accepting new patients with this insurance plan.

  • AETNA [Medicare]
  • Aetna - Weill Cornell [POS]
  • Affinity Essential
  • Affinity Health Plan
  • Blue Priority Network
  • Emblem Select Care
  • Empire Blue Cross/Blue Shield [Pathway X]
  • Empire Blue Cross/Blue Shield [Pathway X Enhanced]
  • Empire Blue Cross/Blue Shield [PPO]
  • Empire Blue Cross/Blue Shield [EPO]
  • Empire Blue Cross/Blue Shield [HMO]
  • Empire Blue Cross/Blue Shield [Mediblue (Senior)]
  • Fidelis Care
  • GHI [CBP]
  • Health First
  • Health Insurance Plan of NY (HIP) [Medicare]
  • Health Insurance Plan of NY (HIP)
  • Health Insurance Plan of NY (HIP) [Medicaid]
  • Health Plus - Amerigroup [CHP]
  • Health Plus - Amerigroup
  • Health Republic
  • Oscar
  • Oxford Health Plans [Medicare Advantage]
  • Oxford Health Plans [Freedom]
  • Oxford Health Plans [Liberty]
  • Rockefeller University - CoreSource
  • UHC Compass
  • United Empire
  • United Health Care [Medicare]
  • United Health Care
  • United Health Care [Community Plan]
  • VNSNY CHOICE Medicare [Medicare]
  • VNSNY CHOICE Medicare [HMO]



Said J, Cesarman E, Knowles DM: Lymphadenopathy and the lymphoid neoplasms associated with HIV infection and other causes of immunosuppression. In: Knowles’ Neoplastic Hematopathology. 3rd Ed. Orazi A, Weiss L, Foucar K, Knowles DM (Eds). Lippincott Williams and Wilkins, Philadelphia, 2013.

Wang, YL, Cesarman E, Knowles DM: Antigen receptor genes: Structure, function, and molecular analysis in clinical applications. In: Knowles’ Neoplastic Hematopathology. 3rd Ed Orazi A, Weiss L, Foucar K, Knowles DM (Eds). Lippincott Williams and Wilkins, Philadelphia, 2013.


Boiocchi L, Mathew S, Gianelli U, Iurlo A, Radice T, Barouk-Fox S, Knowles DM, Orazi A: Morphologic and cytogenetic differences between post-polycythemic myelofibrosis and primary myelofibrosis in fibrotic stage.Mod Pathol. 2013 Dec;26(12):1577-85.

Boiocchi L, Espinal-Witter R, Geyer JT, Steinhilber J, Bonzheim I, Knowles DM, Fend F, Orazi A: Development of monocytosis in patients with primary myelofibrosis indicates an accelerated phase of the disease. Mod Pathol. 2013 Feb;26(2):204-12.

Geyer JT, Verma S, Mathew S, Wang YL, Racchumi J, Espinal-Witter R, Subramaniyam S, Knowles DM, Orazi A: Bone marrow morphology predicts additional chromosomal abnormalities in patients with myelodysplastic syndrome with del. Hum Pathol. 2013 Mar;44(3):346-56.

Cols M, Barra CM, He B, Puga I, Xu W, Chiu A, Tam W, Knowles DM, Dillon SR, Leonard JP, Furman RR, Chen K, Cerutti A: Stromal endothelial cells establish a bidirectional crosstalk with chronic lymphocytic leukemia cells through the TNF-related factors BAFF, APRIL, and CD40L. J Immunol. 2012 Jun 15;188(12):6071-83.

Boiocchi L, Witter RE, He B, Subramaniyam S, Mathew S, Nie K, Cerutti A, Coleman M, Knowles DM, Orazi A, Tam W: Composite chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma are biclonal lymphomas: a report of two cases. Am J Clin Pathol. 2012 Apr;137(4):647-59.

Prakash S, Hoffman R, Barouk S, Wang YL, Knowles DM, Orazi A: Splenic extramedullary hematopoietic proliferation in Philadelphia chromosome-negative myeloproliferative neoplasms: heterogeneous morphology and cytological composition.  Mod Pathol. 2012 Jun;25(6):815-27.

Puga I, Cols M, Barra CM, He B, Cassis L, Gentile M, Comerma L, Chorny A, Shan M, Xu W, Magri G, Knowles DM, Tam W, Chiu A, Bussel JB, Serrano S, Lorente JA, Bellosillo B, Lloreta J, Juanpere N, Alameda F, Baró T, de Heredia CD, Torán N, Català A, Torrebadell M, Fortuny C, Cusí V, Carreras C, Diaz GA, Blander JM, Farber CM, Silvestri G, Cunningham-Rundles C, Calvillo M, Dufour C, Notarangelo LD, Lougaris V, Plebani A, Casanova JL, Ganal SC, Diefenbach A, Aróstegui JI, Juan M, Yagüe J, Mahlaoui N, Donadieu J, Chen K, Cerutti A: B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen. Nat Immunol. 2011 Dec 25;13(2):170-80.

Dornfeld K, Gessert CE, Renier CM, McNaney DD, Urias RE, Knowles DM, Beauduy JL, Widell SL, McDonald BL: Differences in breast tissue oxygenation following radiotherapy.  Radiother Oncol. 2011 Aug;100(2):289-92.

Chiu A, Czader M, Cheng L, Hasserjian RP, Wang M, Bhagavathi S, Hyjek EM, Al-Ahmadie H, Knowles DM, Orazi A: Clonal X-chromosome inactivation suggests that splenic cord capillary hemangioma is a true neoplasm and not a subtype of splenic hamartoma.  Mod Pathol. 2011 Jan;24(1):108-16.

Nie K, Zhang T, Allawi H, Gomez M, Liu Y, Chadburn A, Wang YL, Knowles DM, Tam W: Epigenetic down-regulation of the tumor suppressor gene PRDM1/Blimp-1 in diffuse large B cell lymphomas: a potential role of the microRNA let-7. Am J Pathol. 2010 Sep;177(3):1470-9.

Chen YT, Chadburn A, Lee P, Hsu M, Ritter E, Chiu A, Gnjatic S, Pfreundschuh M, Knowles DM, Old LJ: Expression of cancer testis antigen CT45 in classical Hodgkin lymphoma and other B-cell lymphomas.  Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3093-8.

Song Z, Lu P, Furman RR, Leonard JP, Martin P, Tyrell L, Lee FY, Knowles DM, Coleman M, Wang YL: Activities of SYK and PLCgamma2 predict apoptotic response of CLL cells to SRC tyrosine kinase inhibitor dasatinib. Clin Cancer Res. 2010 Jan 15;16(2):587-99.

Ouansafi I, He B, Fraser C, Nie K, Mathew S, Bhanji R, Hoda R, Arabadjief M, Knowles D, Cerutti A, Orazi A, Tam W. Transformation of follicular lymphoma to plasmablastic lymphoma with c-myc gene rearrangement. Am J Clin Pathol. 2010 Dec;134(6):972-81.

Honors and Awards

1992-2012: Best Doctors in America, Castle Connelly

2011-2012: Super Doctors, New York Times Magazine

2001 - 2009: Best Doctors in New York, New York Magazine

2009: Recipient of the Maurice R. Greenberg Distinguished Service Award

2007: ASCP Philip Levine Award for Outstanding Research

1987: Arthur Purdy Stout Prize