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Alain Borczuk, M.D.
Diagnostic patient care has been my focus in neoplastic and non-neoplastic pulmonary pathology. In rendering an opinion, the pathologist must go beyond diagnosis by actively participating in multidisciplinary discussions and incorporating those conclusions into a larger interpretation. In neoplastic lung disease, this largely involves matching the surgical, oncologic and imaging features with the histopathology to assure an accurate tumor classification. In non-neoplastic lung disease, the incorporation of imaging and physiology, as well as clinical presentation, is critical to providing the best patient care that pathology can provide.
The main focus of my research interest has been in the characterization of lung adenocarcinoma with an emphasis on invasion acquisition. The transition from pre-invasive precursor lesions to invasive adenocarcinoma with metastatic potential has been an area of intense examination. In the course of these studies, combining morphologic examination with whole exome sequencing, copy number analysis, gene expression profiling and laser capture microdissection has led to observations linking acquisition of invasion to gene expression differences. Prior work led to the identification of TGFBR2 loss as a critical step in the progression of early lung adenocarcinoma, culmination in a mouse model that closely resembles the human in-situ to invasive transition. This was performed in conjunction with the examination of a large cohort of lung adenocarcinoma patients in which pathologic characterization led to conclusions regarding invasive size measurement in lung adenocarcinoma. Most recently, application of NGS combined with morphologic assessment led to the finding of a high rate of actionable MET exon 14 skipping mutations in an aggressive subtype of lung carcinoma - pulmonary sarcomatoid carcinoma.
Teaching of medical students, residents, fellows and other physicians was a major reason for selecting Pathology as a career, and this remains an integral component of my academic activity. Through clear presentation, apt analogies and an ability to distill the critical teaching points from subject matter, I have been able to maintain a high level of learner satisfaction, manifested by longevity in teaching roles, positive verbal and written evaluations, and invited participation in regional and national venues.
In addition, through the New York Pathological Society, Pulmonary Pathology Society, College of American Pathologists and the American Society of Clinical Pathologists, I have used both regional and national platforms to educate pathologists about Molecular Biology with the goal of updating and re-educating practicing pathologists in an era of rapidly evolving Molecular Pathology, with a focus on lung cancer and mesothelioma.
Specialties & Expertise
- Anatomic Pathology
- Pulmonary Pathology
- Lung Cancer
- Mesothelioma of Peritoneum
- Mesothelioma of Pleura
- Interstitial Lung Disease
Insurance Plans Accepted
The following represents most of the managed care plans accepted by this physician. If your insurance carrier does not appear here please contact the physician’s office as they may have individual contracts not included on this site.
* indicates this physician is no longer accepting new patients with this insurance plan.
- AETNA - PPO
- AETNA - Medicare
- AETNA - HMO
- Aetna - Weill Cornell - POS
- Affinity Access
- Affinity Health Plan
- Amida Care
- Blue Priority Network
- Emblem Select Care
- Empire Blue Cross/Blue Shield - PPO
- Empire Blue Cross/Blue Shield - Pathway X
- Empire Blue Cross/Blue Shield - Pathway X Enhanced
- Empire Blue Cross/Blue Shield - NYPH Employees Only
- Empire Blue Cross/Blue Shield - Mediblue (Senior)
- Empire Blue Cross/Blue Shield - HMO
- Empire Blue Cross/Blue Shield - EPO
- Empire Empire Blue Cross/Blue Shield HealthPlus
- Empire Empire Blue Cross/Blue Shield HealthPlus - CHP
- Fidelis Care
- GHI - CBP
- Health First
- Health Insurance Plan of NY (HIP) - Medicaid
- Health Insurance Plan of NY (HIP) - Medicare
- Health Insurance Plan of NY (HIP)
- Oxford Health Plans - Medicare Advantage
- Oxford Health Plans - Metro/Core/Charter
- Oxford Health Plans - Freedom
- Oxford Health Plans - Liberty
- Rockefeller University - CoreSource
- UHC Compass
- United Empire
- United Health Care
- United Health Care - Medicare
- United Health Care - Community Plan
- VNSNY CHOICE - Medicare
- VNSNY CHOICE - HMO
- WellCare Health Plans
Clinical & Academic Positions
Professor of Pathology and Laboratory Medicine
Weill Cornell Medical College, Cornell University
Education & Training
- M.D., Cornell University Medical College, 1991
- A.B., Princeton University, 1987
Honors & Awards
Alpha Omega Alpha, 1991
Castle Connolly, America's Top Doctors, 14th EditionCastle Connolly Top Doctors: New York Metro Area, 18th Edition
Castle Connolly, America's Top Doctors for Cancer, 10th edition
New York Magazine, Top Doctors, 2014,2015
Dr. Borczuk is a graduate of NYC's Stuyvesant High School. After graduating Summa Cum Laude from Princeton University in the Department of Molecular Biology, he attended Cornell University Medical College, from where he received his MD degree in 1991. He completed his internship in Internal Medicine at The New York Hospital, and completed his residency in Anatomic Pathology at the Albert Einstein College of Medicine. After serving as an attending pathologist at Jacobi Medical Center and North Shore University Hospital, he joined the Department of Pathology at Columbia University Medical Center in 1999. As a practicing pathologist, translational researcher, and active participant in the Pulmonary Program at Columbia, he achieved the rank of Professor of Pathology at Columbia University Medical College. He joined the faculty at Weill Cornell in 2015 as Vice Chairman and Director of Anatomic Pathology, as well as Chief of Thoracic Pathology.