Yao-Tseng Chen, B.M., Ph.D.

Yao-Tseng Chen

Dr. Chen is a surgical pathologist and a molecular pathologist.

Dr. Chen's research interests are human tumor immunology and molecular pathology of solid tumors. In tumor immunology, the focus of the laboratory has been in cancer antigen discovery, particularly in the identification of tumor antigens that can be used for therapeutic cancer vaccines. In collaboration with the Ludwig Institute for Cancer Research, New York Branch for over 15 years, this effort has resulted in the identification and characterization of many tumor antigens in various tumors. In melanoma, we have produced and characterized monoclonal antibodies against melanocyte differentiation antigens tyrosinase (T311) and Melan-A (A103). These antibodies are not only useful in selecting patients for antigen-specific cancer vaccine trials but have also emerged as the most useful antibodies in the diagnosis of metastatic melanomas. In other types of solid tumors, the research focus of our laboratory has been on cancer/testis (CT) antigens, a group of antigens that were normally expressed only in germ cells of the testis but were found to be aberrantly expressed in human cancers. Our lab has identified many CT antigens, including NY-ESO-1, SSX, CT7, CT10, and more recently CT45, CT46 and CT47 etc. Multiple international cancer vaccine trials using NY-ESO-1 as the antigen target are currently ongoing. The mRNA and protein expression of other CT antigens are being evaluated to identify the most promising ones for cancer immunotherapy.

In molecular pathology of the solid tumors, Dr. Chen is interested in identifying molecular markers that can be useful in the diagnosis, treatment, or prognostication in the solid tumors. Over the last several years, multiple projects have been carried out in collaboration with faculty members in various subspecialty areas of surgical pathology, many of them involving residents and fellows. The projects completed to date encompass tumors of the gastrointestinal tract, lung, thyroid, breast, kidney, prostate, bladder, salivary gland etc.

Dr. Chen received his medical degree from National Taiwan University, School of Medicine. He then received Ph.D. degree in Immunology from the Sloan-Kettering Division of the Graduate School of Medical Sciences, Cornell University Medical College. He received his postgraduate training at the New York Hospital and is certified for Anatomic and Clinical Pathology.

Insurances

Insurance Plans Accepted

The following represents most of the managed care plans accepted by this physician. If your insurance carrier does not appear here please feel free to contact this physician or this physician's practice as they may have individual contracts not included on this site.

  • AETNA [HMO]
  • AETNA [PPO]
  • AETNA [Medicare]
  • Aetna - Weill Cornell [POS]
  • Affinity Essential
  • Affinity Health Plan
  • Blue Priority Network
  • CIGNA
  • Emblem Select Care
  • Empire Blue Cross/Blue Shield [Pathway X]
  • Empire Blue Cross/Blue Shield [Pathway X Enhanced]
  • Empire Blue Cross/Blue Shield [PPO]
  • Empire Blue Cross/Blue Shield [EPO]
  • Empire Blue Cross/Blue Shield [HMO]
  • Empire Blue Cross/Blue Shield [Mediblue (Senior)]
  • Fidelis Care
  • GHI [CBP]
  • Health First
  • Health Insurance Plan of NY (HIP) [Medicare]
  • Health Insurance Plan of NY (HIP) [Medicaid]
  • Health Insurance Plan of NY (HIP)
  • Health Plus - Amerigroup [CHP]
  • Health Plus - Amerigroup
  • Health Republic
  • Medicare
  • Medicare [Medicare]
  • Oscar
  • Oxford Health Plans [Liberty]
  • Oxford Health Plans [Medicare Advantage]
  • Oxford Health Plans [Freedom]
  • POMCO
  • Rockefeller University - CoreSource
  • UHC Compass
  • United Empire
  • United Health Care
  • United Health Care [Medicare]
  • United Health Care [Community Plan]
  • VNSNY CHOICE Medicare [Medicare]
  • VNSNY CHOICE Medicare [HMO]

Publications

 

Y.-T. Chen, M. J. Scanlan, C. A. Venditti, R. Chua, Theiler, G., B. J. Stevenson, C. Iseli, A. O. Gure, T. Vasicek, R. L. Strausberg, C. V. Jongeneel, L. J. Old, and A. J. G. Simpson: Identification of cancer/testis-antigen genes by massively parallel signature sequencing. Proc. Natl. Acad. Sci.USA 102:7940-7945, 2005.

Y.-T. Chen, C. Iseli, C. A. Venditti, L. J. Old, A. J. G. Simpson, and C. V. Jongeneel: Identification of a new cancer/testis gene family, CT47, among expressed multi-copy genes on the human X chromosome. Genes Chromosomes & Cancer 45:392-400, 2006.

T. Scognamiglio, E. Hyjek, J. Kao, and Y.-T. Chen: Diagnostic utility of HBME1, Galectin3, CK19, and CITED1 and evaluation of their expression in encapsulated lesions with questionable features of papillary thyroid carcinoma. Am. J. Clin. Pathol. , 2006.

S. Rohan, J. J. Tu, J. Kao, P. Mukherjee, F. Campagne, X. K. Zhou, E. Hyjek, M. A. Alonso, and Y.-T. Chen: Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes. Clin. Cancer Res. 12:6837-6945, 2006.

R. K. Yantiss, A. M. Panczykowski, J. Misdraji, R. D. Odze, and Y.-T. Chen: A comprehensive study of non-dysplastic and dysplastic serrated lesions of the vermiform appendix. Am. J. Surg. Pathol. 31:1742-1753, 2007.

J. J. Tu, S. Rohan, J. Kao, N. Kitabayashi, S. Mathew and Y.-T. Chen: Gene Fusions between TMPRSS2 and ETS Family Genes in Prostate Cancer: Frequency and Transcript Variant Analysis by RT-PCR and FISH on Paraffin-Embedded Tissues. Mod. Pathol. 20:921-928, 2007.

Y. B. Chen, J. J. Tu, J. Kao. X. K. Zhou, and Y.-T. Chen: Survivin as a useful adjunct marker for the grading of papillary urothelial carcinoma. Arch. Pathol. Lab. Med. 132:224-231, 2008.

P. L. Wagner, Y.-T. Chen, and R. K. Yantiss: Immunohistochemical and molecular features of sporadic and FAP-associated duodenal adenomas of the ampullary and non-ampullary mucosa. Am. J. Surg. Pathol. 32:1388-1395, 2008.

Y.-T. Chen, N. Kitabayashi, X. K. Zhou, T. J. Fahey III and T. Scognamiglio: MicroRNA analysis as a potential diagnostic tool for papillary thyroid carcinoma. Mod. Pathol. 21: 1139-1146, 2008.

O. Hofmann, O. L. Caballero, B. J. Stevenson, Y.-T. Chen, T. Cohen, R. Chua, C. A. Maher, S. Panji, U. Schaefer, A. Kruger, M. Lehvaslaiho, P. Carninci, Y. Hayashizaki, C. V. Jongeneel, A. J. Simpson, L. J. Old, and W. Hide: Genome-wide analysis of cancer/testis gene expression. Proc. Natl. Acad. Sci. USA 105:20422-20427, 2008.

L. G. Almeida, N. J. Sakabe, A. R. Deoliveira, M. C. Silva, A.S. Mundstein, T. Cohen, Y.-T. Chen, R. Chua, S. Gurung, S. Gnjatic, A. A. Jungbluth, O. L. Caballero, A. Bairoch, E. Kiesler, S. L. White, A. J. Simpson, L. J. Old, A. A. Camargo, and A. T. Vasconcelos: CTdatabase: a knowledge-base of high-throughput and curated data on cancer-testis antigens. Nucleic Acids Res. 37: D816-819, 2009.

R. K. Yantiss, M. Goodarzi, X. K. Zhou, H. Rennert, E. C. Pirog, B. F. Banner, and Y.-T. Chen: Clinical, Pathologic, and Molecular Features of Early-onset Colorectal Carcinoma. Am. J. Surg. Pathol. 33:572-582, 2009.

E. C. Kauffman, D. A. Barocas, Y.-T. Chen, X. J. Yang, D. S. Scherr, and J. J. Tu: Differential Expression of KAI1 Metastasis Suppressor Protein in Renal Cell Tumor Histological Subtypes. J. Urol. 181:2305-2311, 2009.

Y.-T. Chen, M. Hsu, P. Lee, S. J. Shin, P. Mhawech-Fauceglia, K. Odunsi, N. K. Altorki, C. J. Song, B. Q. Jin, A. J. Simpson, and L. J. Old: Cancer/testis antigen CT45: Analysis of mRNA and protein expression in human cancer. Int. J. Cancer 124:2893-2898, 2009.

A Grigoriadis, O. L. Caballero, K. S. Hoek, L. da Silva, Y.-T. Chen, S. J. Shin, A. A. Jungbluth, L. D. Miller, D. Clouston, J. Cebon, L. J. Old, S. R. Lakhani, A. J. G. Simpson, and A. M. Neville: CT-X antigen expression in human breast cancer. Proc. Natl. Acad. Sci. USA. 106: 13493-13498, 2009.

O. L. Caballero and Y.-T. Chen: Cancer/testis antigens: Potential targets for immunotherapy. Cancer Sci. 100: 2014-2021, 2009.

Y.-T. Chen, A. Chadburn, P. Lee, M. Hsu, E. Ritter, A. Chiu, S. Gnjatic, M. Pfreudschuh, D. M. Knowles and L. J. Old: Expression of cancer testis antigen CT45 in classical Hodgkin lymphoma and other B-cell lymphomas. Proc. Natl. Acad. Sci. USA. 107: 3093-3098, 2010.

S. Gnjatic, E. Ritter, M. W. Buchler, N. A. Giese, B. Brors, A. Murray, N. Halama, I. Zomig, Y.-T. Chen, C. Andrews, G. Ritter, L. J. Old, K. Odunsi, and D. Jager:  Seromic profiling of ovarian and pancreatic cancer. Proc. Natl. Acad. Sci. USA.  107: 5088-5093, 2010.