Wayne Tam, M.D., Ph.D.

Anatomic Pathology
Wayne Tam

Dr. Wayne Tam is an academic hematopathologist in the Division of Hematopathology of the Department of Pathology and Laboratory Medicine at Weill Cornell Medical Center, with experitise in bone marrow and lymph node pathology, flow cytometry, immunohistochemistry and molecular hematopathology.  Besides practising clinical hematopathology in an internationally renowned hematopathology group, Dr. Tam also directs a funded translational research program which aims at understanding the pathogenesis of leukemias and lymphomas and identifying biomarkers with implications in diagnosis and prognosis of these cancers.  His research focuses on studies in the role of microRNAs and tumor suppressor genes in hematopoietic malignancies.  He has actively published in peer-reviewed journals in these areas and is a recognized expert in microRNAs and cancer.  He has been an invited speaker in several national and international conferences.  Dr. Tam serves as an Editorial Board Member of Molecular Medicine Reports and is an ad hoc reviewer for more than 10 peer-reviewed journals, including Blood, Clinical Cancer Research, Human Pathology, Laboratory Investigation, and Journal of Biological Chemistry.  He is currently a member of the Translational Research Committee of the Department and the Director of the Tumor Bank in the Division of Hematopathology.  He is also the case review pathologist of the AIDS Malignanices Clinical Trial Consortium.  He recently received the Eminent Scientist of the Year Award in Cancer Research and Gene Biology by the International Research Promotion Council.  Dr. Tam's ultimate goal is to integrate his clinical and research expertise to faciliate discovery of novel target therapy for the benefit of patients with lymphomas and leukemias.

Dr. Wayne Tam received his undergraduate education at The Johns Hopkins University  with honors and subsequently graduated from the Cornell-Rockefeller-Memorial Sloan-Kettering Tri-Institutional combined MD and PhD program. He was then recruited to the pathology residency training program here at New York Presbyterian Hospital-Cornell Medical Center. After his residency training in anatomic pathology,  he completed a hematopathology fellowship at Cornell and served as a Leukemia and Lymphoma Soceity research fellow in the Institute of Cancer Genetics, Columbia University College of Physicians and Surgeons, under the tutelage of Dr. Riccardo Dalla-Favera . Dr. Tam was appointed as Instructor in Pathology in February 2001 and subsequently promoted to Assistant Professor in July 2002. Dr. Tam's clinical responsibilites are concentrated in hematopathology while he pursues his translational research program in hematopoeitic malignancies.

Insurances

Insurance Plans Accepted

The following represents most of the managed care plans accepted by this physician. If your insurance carrier does not appear here please feel free to contact this physician or this physician's practice as they may have individual contracts not included on this site.

  • AETNA [HMO]
  • AETNA [PPO]
  • AETNA [Medicare]
  • Aetna - Weill Cornell [POS]
  • Affinity Essential
  • Affinity Health Plan
  • Blue Priority Network
  • CIGNA
  • Emblem Select Care
  • Empire Blue Cross/Blue Shield [Pathway X]
  • Empire Blue Cross/Blue Shield [Pathway X Enhanced]
  • Empire Blue Cross/Blue Shield [PPO]
  • Empire Blue Cross/Blue Shield [EPO]
  • Empire Blue Cross/Blue Shield [HMO]
  • Empire Blue Cross/Blue Shield [Mediblue (Senior)]
  • Fidelis Care
  • GHI [CBP]
  • Health First
  • Health Insurance Plan of NY (HIP) [Medicare]
  • Health Insurance Plan of NY (HIP) [Medicaid]
  • Health Insurance Plan of NY (HIP)
  • Health Plus - Amerigroup [CHP]
  • Health Plus - Amerigroup
  • Health Republic
  • Medicare
  • Medicare [Medicare]
  • Oscar
  • Oxford Health Plans [Liberty]
  • Oxford Health Plans [Medicare Advantage]
  • Oxford Health Plans [Freedom]
  • POMCO
  • Rockefeller University - CoreSource
  • UHC Compass
  • United Empire
  • United Health Care
  • United Health Care [Medicare]
  • United Health Care [Community Plan]
  • VNSNY CHOICE Medicare [Medicare]
  • VNSNY CHOICE Medicare [HMO]

Publications

 

PEER-REVIEWED JOURNAL ARTICLES
 
1. Tam, W.**,Ben-Yehuda, D., Hayward, W.S. bic, a novel gene activated by proviral insertions in avian leukosis virus-induced lymphomas, is likely to function through its non-coding RNA. Mol. Cell. Biol. 17:1490-1502, 1997..
 
2. Tam, W.**Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA. Gene 274:157-167, 2001.
 
3. Tam, W.**, Hughes, S., Hayward, W., Besmer, P. Avian bic, a gene isolated from a common retroviral site in avian-leukosis-virus-induced lymphomas and encoding a noncoding RNA, cooperates with c-myc in lymphomagenesis and erythroleukemogenesis. J. Virol. 76: 4275-4286, 2002.
 
4. Eis, P.S*., Tam, W.*, Sun, L., Chadburn, A., Li, Z., Gomez, M., Lund, E., and Dahlberg, J.E. Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc. Natl. Acad. Sci. USA102(10):3627-32, 2005. *Co-first author.
 
5. Cattoretti, G*., Pasqualucci, L*., Ballon, G., Tam, W., Nandual, S.V., Shen. Q., Mo, T., Murty, V.V., and Dalla-Favera, R.   Deregulated BCL-6 expression recapitulates the pathogenesis of human diffuse large B-cell lymphomas in mice. Cancer Cell 7(5):445-55, 2005. *Co-First Author
 
6. Tam, W.** and Dahlberg, J.E. MiR-155/BIC as an oncogeneic miRNA. Genes Chromosomes Cancer 45:211-212, 2006.
 
7. Tam, W.**, Gomez, M., Chadburn, A., Lee, J.W., Chan, W.C., and Knowles, D.M. Mutatoinal analysis of PRDM1 indicates a tumor suppressor role in diffuse large B-cell lymphomas. Blood 107(10):4090-4100, 2006 (epub on January 19, 2006)
     ***Article featured in Commentary
 
8. Tam, W.**, Gomez, M.F., Houldsworth, J., Chadburn, A. and Knowles, D.M.  Lack of A563G (I188V) missense mutation in diffuse large B-cell lymphomas. Genes Chromosomes Cancer 46(4):416-418, 2007.
 
9. Cheung, K., Tam, W., Chuang E. and Osborne, M.P. A collision tumor consisting of invasive ductal carcinoma and chronic lymphocytic leukemia in breast. The Breast Journal 13(4): 413-417, 2007.
 
10. Landgraf, et al (multiple authors), Tam, W., Borkhardt, A., Sander, C., Zavolam, M. and Tuschl T. A mammilian microRNA Expression Atlas based on small RNA library sequencing. Cell 129:1401-1414, 2007.
 
11. Tam, W. **, Gomez, M., and Kui, N. Significance of PRDM1beta expression as a prognostic marker in diffuse large B-cell lymphomas. Blood 111(4):2488-2489, 2008.
 
12. Wagner, P.L., Tam, W. , Lau, P.Y., Port, J.L., Paul, S., Altorki, N.K., and Lee, P.C. Primary     esophageal   large T Cell lymphoma mimicking esophageal carcinoma: A case report and literature review. The Journal of Thoracic and Cardiovascular Surgery 135 (4):957-958, 2008.
 
13. Nie, K., Gomez, M., Landgraf, P., Garcia, J.F., Liu, Y.,Tan, LHC,Chadburn, A., Tuschl, T., Knowles, D.M., and Tam, W**. MicroRNA-mediated translational repression of PRDM1 in Hodgkin/Reed-Sternberg cells - a potential pathogenetic lesion in Hodgkin lymphoma. Am J Path 173 (1):242-52, 2008.
 
14. Zhang, T., Kui, N., and Tam, W**. BIC/microRNA-155 is processed efficiently in Burkitt lymphomas. Leukemia 22:1795-1797, 2008.
 
15. Mavrakis, K.J., Zhu, H., Silva, R.L.A., Mills, J., Teruya-Feldstein, J., Lowe, S.W., Tam, W., Pelletier, J., and Wendel., H.G. Tumorigenic activity and therapeutic inhibition of Rheb GTPase  Genes & Dev 22:2178-2188, 2008.
  
16. Chadburn, A., Hyjek, E.M., Tam, W., Liu, Y.F., Rengifo, T., Cesarman, E. and Knowles, D.M.   Immunophenotypic analysis of the Kaposi Sarcoma Herpesvirus (KSHV;HHV-8) infected B cells in HIV-positive multicentric Castleman disease (MCD). Histopathology, 53(5):513-524, 2008.
 
17. Iqbal, J.*, Kucuk, C.*, deLeeuw, R.J., Srivastava, G., Tam, W., Geng, H., Klinkebiel,, D., Christman, J., Patel, K., Cao, K., Shen, L., Dybkaer,K., Tsui, I., Ali,H.H., Shimizu, N., Au, W.Y., Lam, W.L., and Chan, W.C.  Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies. Leukemia, 2009, in press *co-first authors
 
18. Nie, K., Zhang T., Allawi, H. Gomez, M., Liu, Y., Chadburn, A., Wang, Y.L. Knowles, D.M., and Tam, W**. Down-regulation of PRDM1/Blimp-1 in diffuse large B-cell lymphomas: Potential role of microRNA let-7 (under review by Hematologica)
 
19. Fraser, C.., Zhang, T., Gomez, M., Mathew, S., Furman, R., Orazi, A. and Tam, W**. Clonal transformation of   chronic lymphocytic leukmemia/small lymphocytic lymphoma to interdigitating cell sarcoma (under review by Am J Path)
  
 
 
INVITED COMMENTARY & REVIEW ARTICLES
 
1. Tam, W. ** The emergent role of microRNAs in molecular diagnostics of cancer. Journal of Molecular Diagnostics, 10(5): 411-414, 2008 [Invited commentary]
 
2. Tam, W. **    MicroRNAs and hematopoietic malignancies: Pathogenesis, diagnosis and prognosis. Expert Reviews of Molecular Diagnostics, 2009, in preparation [Invited review]
 
 
REVIEWS
 
1. Tam, W.** MicroRNAs: tiny but not trivial.   Current Genomics, 5(3):191-205, 2004.
 
2 . Zhang, W., Dahlberg, J.E., and Tam, W.** MicroRNAs in Tumorigenesis: A Primer. Am J Path 171(3):728-738, 2007.
   
** Corresponding author
 
 
BOOK CHAPTERS
 
1. Tam, W., Dalla-Favera, R. Protooncogenes and tumor suppressor genes in hematopoietic malignancies. In: Neoplastic Hematopathology (2nd), Knowles, D.M. (ed) W.B. Sauders (publ), 329-363, 2000.
 
2. Chiu, A., Tam, W., Cines, D. and Bussell, J.B. Immune thrombocytopenic purpura: pathophysiology in patients with persistent problems. In: Postgraduate Hematology (5th), S. Lewis , I. Avivi , T. Tuddenham, D. Catovsky, A. A.V. Hoffbrand (ed.) Blackwell Science (publ), 937-944, 2005.
 
 
PH.D. THESIS
 
Cloning and characterization of bic, a novel myc collaborator in lymphomagenesis and leukemogenesis. Cornell University, New York.
 

Honors and Awards

 

1988                   Phi Beta Kappa
1988                   Honors in Natural Sciences, The Johns Hopkins University
1995                   Lili Foo-Hing Li Fellowship for M.D.-Ph.D. trainees
1998                                      Distinguished Housestaff Award
1999                                      Leukemia & Lymphoma Society Fellowship
2004                   Alternate Recipient, Kimmel Scholar Award, Sidney Kimmel Foundation for Cancer  Research
2008                   Eminent Scientist of the Year, Cancer Research & Gene Biology, International Research Promotion Council