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Steven M. Lipkin, MD, PhD

Clinical Genetics and Genomics (MD)

Locations and Appointments

Insurances Accepted

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Personal Statement

Dr. Lipkin is a physician-scientist who has published in Cell, Cell Stem Cell, Nature Biotechnology, Nature Genetics, Science, Genes and Development, Proceedings of the National Academy of Sciences and Journal of Clinical Investigation, among others.

He is Vice Chair for Research, Weill-Cornell Department of Medicine. He is a member of the FDA Molecular and Clinical Genetics Panel, which reviews and votes on approval of new genetic tests in the US. He is Director of the Weill Cornell Medical College Adult and Cancer Genetics Clinic, where he practices as a Clinical Geneticist and supervises Genetic Counselors, and Director of the Program in Mendelian Genetics.  He directs a research laboratory that uses massively parallel sequencing, computational biology, mouse models, cell culture and genomics to understand the contribution of genetics to, and mechanisms of, hereditary cancer genetic syndromes. He discovered and mechanistically characterized MLH3, a DNA mismatch repair gene colorectal polyposis and cancer predisposition gene. He has also identified or co-identified 6 B cell malignancy predisposition genes. His lab made important contributions to our understanding of cancer initiating cells and was also the first to model human cancer cells in immune competent mice. He currently leads an NCI multi-institutional Center for Cancer Immunoprevention.  He is currently working on developing and validating precision prevention and precision therapies for patients with DNA repair deficient cancers.

Biographical Info

GENETIC TESTING, WELLNESS WHOLE EXOME AND GENOME SEQUENCING, EXECUTIVE MEDICINE, ADULT GENETIC DISEASES INCLUDING LYNCH SYNDROME/HNPCC, FAMILIAL ADENOMATOUS POLYPOSIS, HEREDITARY BREAST AND PANCREATIC CANNCER, LI-FRAUMENI, JUVENILE POLYPOSIS, PEUTZ-JEGHERS SYNDROME AND OTHER DISORDERS

Dr. Lipkin is a board certified Medical Geneticist with a focus on genetic testing for adult and cancer genetic diseases, including the Lynch Syndrome, Familial Adenomatous Polyposis, and Hereditary Pancreatic Cancer among others. He is an authority on cancer and adult genetic syndromes, with a particular emphasis on hereditary Gastrointestinal cancer syndromes. He is the author of MAPP-MMR, a bioinformatic program that is used to interpret whether Lynch syndrome missense variants are deleterious mutations or benign polymorphisms. He practices at Weill Medical College of Cornell University and New York-Presbyterian Hospital. He trained in Internal Medicine at Duke University and Medical Genetics at the National Human Genome Research Institute.

Honors and Awards

2015-Fellow, American Society of Clinical Investigation (ASCI)

2013 Adjunct Professor of Medicine, School of Basic Medical Sciences, Beijing University

2005-Athalie Clark Junior Faculty Research Scholar Award

2005-2003 American Cancer Society Research Scholar

2000 Board Certification American College of Medical Genetics

1999 Board Certification, American Board of Internal Medicine

1995-1986 NIH Medical Scientist Training Program Fellowship   

1986 Summa cum laude, Princeton University

1986 Phi Beta Kappa, Princeton University

Board Certifications
American Board of Medical Genetics
Clinical Expertise
Cancer Genetics
Whole Exome Sequencing
Genetic Testing
Inflammatory Bowel Disease (IBD)
Gastrointestinal Cancer
General Gastroenterology
Genetic Screening
Languages
English
Education 
  • M.D., Ph.D.
    University of California, San Diego School of Medicine
    1995
  • B.A.
    Princeton University
    1986
Appointments 
  • Professor of Genetic Medicine
    Weill Cornell Medical College, Cornell University
  • Professor of Medicine
    Weill Cornell Medical College, Cornell University
  • Gladys and Roland Harriman Professor of Medicine
    Weill Cornell Medical College, Cornell University
  • Attending Physician
    NewYork-Presbyterian Hospital

Relationships and collaborations with for-profit and not-for profit organizations are of vital importance to our faculty because these exchanges of scientific information foster innovation. As experts in their fields, WCM physicians and scientists are sought after by many organizations to consult and educate. WCM and its faculty make this information available to the public, thus creating a transparent environment.

Consultant: 
AnaNeo Therapeutics
Ownership: 
AnaNeo Therapeutics