Ralph L. Nachman, M.D.

Medical Oncology
Ralph Nachman

Dr. Ralph L. Nachman, the Lewis Thomas University Professor and Associate Dean of Clinical Research at Weill Cornell Medical College, is a physician, scientist, educator and administrator. Dr. Nachman has pioneered discoveries in hematology and medical oncology that have furthered the development of new clinical solutions to blood and vascular disorders.

In 1963, he began a more than 40-year career with New York Presbyterian Hospital and Weill Cornell Medical College, beginning as Director of Laboratories for Clinical Pathology, followed by his 25 years as Chief, Division of Hematology and Oncology and 17 years as Chairman of the Department of Medicine at Weill Cornell Medical College and Physician-in-Chief at New York Presbyterian Hospital.

Dr. Nachman has spearheaded multiple endeavors in biomedical research, clinical programs, educational curricula, residency training, fundraising, and quality assurance. His discoveries in vascular biology, and the establishment of the Specialized Center of Research (SCOR) in Thrombosis (National Institutes of Health) at New York-Cornell, led to his performing the first culture of human endothelial cells. This achievement initiated a modern explosion of knowledge in vascular biology. He has published numerous articles in the field of hematology and has lectured around the world. His honors include, The Stratton Award from the American Society of Hematology and the Robert Williams, MD Distinguished Chair of Medicine Award from the Association of Professors of Medicine. He is a member of the Institute of Medicine of the National Academy of Sciences.

1963-1969         Director, Laboratories for Clinical Pathology, New York Hospital

1963-1965         Instructor in Medicine, Cornell Medical Center

1965-1972         Assistant Professor, Medicine, Cornell Medical Center 

1968-1972         Associate Professor, Medicine, Cornell Medical Center

1968-1993         Chief, Division of Hematology, Cornell Medical Center

1968-1972         Associate Attending Physician, The New York Hospital

1969-1970         Guest Investigator, The Rockefeller University

1972-                Attending Physician, New York Presbyterian Hospital

1972-                Professor of Medicine, Cornell Medical Center

1974-1978         Vice Chairman, Department of Medicine, Cornell University Medical College

1976-1996         Director, Specialized Center of Research (SCOR) in Thrombosis,     Cornell University Medical College

1979-1991         Co-director, Rockefeller-Cornell M.D.- Ph.D. Program

1987-1989         Board of Overseers, Cornell University Medical College

1990-2007         Chairman, Department of Medicine, Weill Medical College of Cornell University

1990-2007         Physician-in-Chief, New York Presbyterian Hospital

1992-2007         The E. Hugh Luckey Distinguished Professor in Medicine

2007-                Associate Dean, Clinical Research

2007-                Lewis Thomas University Professor

Insurances

Insurance Plans Accepted

The following represents most of the managed care plans accepted by this physician. If your insurance carrier does not appear here please feel free to contact this physician or this physician's practice as they may have individual contracts not included on this site.

  • AETNA [HMO]
  • AETNA [Medicare]
  • AETNA [PPO]
  • Aetna - Weill Cornell [POS]
  • Affinity Health Plan
  • CIGNA
  • Empire Blue Cross/Blue Shield [EPO]
  • Empire Blue Cross/Blue Shield [HMO]
  • Empire Blue Cross/Blue Shield [Mediblue (Senior)]
  • Empire Blue Cross/Blue Shield [PPO]
  • Fidelis Care
  • Health Insurance Plan of NY (HIP) [Medicaid]
  • Health Insurance Plan of NY (HIP)
  • Health Insurance Plan of NY (HIP) [Medicare]
  • Medicare [Medicare]
  • Oxford Health Plans [Medicare Advantage]
  • Oxford Health Plans [Freedom]
  • Rockefeller University - CoreSource
  • United Empire
  • United Health Care [Community Plan]
  • United Health Care [Medicare]
  • United Health Care

Publications

Selected peer-reviewed publications (in chronological order).

(Selected  from approximately 150 peer-reviewed publications)

 

1.   Nachman, R.L., Hubbard, A., and Ferris B. Iodination of the human platelet membrane: Studies of the major surface glycoprotein. J. Biol. Chem. 248:2928, 1973.

 

2.   Jaffe, E.A., Nachman, R.L., Becker, C., and Minick, C.R. Studies on cultured human endothelial cells derived from umbilical cord veins. J. Clin. Invest. 52:2745, 1973.

 

3.   Jaffe, E.A., Hoyer, L., and Nachman, R.L. Synthesis of AHF antigens by cultured human endothelial cells. J. Clin. Invest. 52:2757, 1973.

 

4.   Nachman, R.L. and Ferris, B. Binding of adenosine diphosphate by isolated membranes from human platelets. J. Biol. Chem. 249:704, 1974.

 

5.   Jaffe, E., Hoyer, L., and Nachman, R.L. Synthesis of von Willebrand factor by cultured human endothelial cells. Proc. Nat. Acad. Sci. 71:1906, 1974.

 

6.   Jaffe, E.A. and Nachman, R.L. Subunit structure of factor VIII antigen synthesized by cultured human endothelial cells. J. Clin. Invest. 56:698-702, 1975.

 

7.   Nachman, R.L., Levine, R., and Jaffe, E.A. Synthesis of factor VIII antigen by cultured guinea pig megakaryocytes. J. Clin. Invest. 60:914-921, 1977.

 

8.   Nachman, R.L., Jaffe, E.A., Miller, C., and Brown, W.T. Structural analysis of Factor VIII antigen in von Wille- brand's disease. Proc. Nat. Acad. Sci. U.S.A. 77:6832-6836, 1980.

 

9.   Leung, L., Kinoshita, T., and Nachman, R.L. Isolation, purification and partial characterization of platelet mem­brane glycoproteins IIb and IIIa. J. Biol. Chem. 256:1994-1997, 1981.

 

10.  Jaffe, E., Leung, L.L.K., Nachman, R.L., Levin, R., and Mosher, D.F. Thrombospondin is the endogenous lectin of human platelets. Nature 295:246-248, 1982.

 

11   Leung, L.L.K., and Nachman, R.L. Complex formation of platelet thrombospondin with fibrinogen. J. Clin. Invest. 70:542-549, 1982.

 

12.  Nachman, R.L., Leung, L.L.K., Kloczewiak, M., and Hawiger, J. Complex formation of platelet membrane glycoproteins IIb and IIIa with fibrinogen D domain. J. Biol. Chem.  259:8584-8588, 1984.

 

13.  Silverstein, R.L., Leung, L.L.K., Harpel, P.C., and Nachman, R.L. Complex formation of platelet thrombospondin with plasminogen: modulation of activation by tissue activator.  J. Clin. Invest. 74:1625-1633, 1984.

 

14.  Silverstein, R.L., Leung, L.L.K., Harpel, P.C. and Nachman, R.L. Platelet thrombospondin forms a trimolecular complex with plasminogen and histidine rich glycoprotein.  J. Clin. Invest. 75:2065-2073, 1985.

 

15.  Nachman, R.L., Hajjar, K.A., Silverstein, R.L., and Dinarel­lo, C. Interleukin-1 induces endothelial cell synthesis of plasminogen activator inhibitor. J. Exp. Med. 163: 1595-1600, 1986.

 

16.  Silverstein, R.L. and Nachman, R.L. Thrombospondin binds to monocytes-macrophages and mediates platelet  monocyte adhesion. J. Clin.Invest. 79: 867-87, 1987.

 

17. Knudsen, B.S., Harpel, P.C., and Nachman, R.L. Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells.  J. Clin. Invest. 80:1082-1089, 1987.

 

18.  Konkle, B.A., Shapiro, S.S., Asch, A.S., and Nachman, R.L. Cytokine enhanced expression of Glycoprotein 1ba in human endothelium. J.Biol.Chem. 265:19833-19838,1990.

 

19.  Etingin, O.R., Hajjar, D.P., Hajjar, K.A., Harpel, P.H., and Nachman, R.L.  Lipoprotein(a) regulates plasminogen activa­tor inhibitor-1 expression in endothelial cells: A potential mechanism in thrombogenesis.  J. Biol. Chem. 266:2459-2465, 1991.

 

20.  Asch, A.S., Tepler, J., Silbiger, S. and Nachman, R.L. Cellular attachment to TSP: Cooperative interactions between receptor systems. J. Biol. Chem. 266:1740-1745,1991.

 

21.  Nachman, R.L. Thrombosis and Atherogenesis: Molecular Connections. Blood 79:1897-1906, 1992.

 

22.  Nicholson, A., Nachman R.L., Altieri, D.C., Summers, B.D., Ruf, W., Edgington, T.S., and Hajjar., D. Effector cell protease receptor-1 is a vascular receptor for coagulation factors Xa.  J. Biol. Chem 271:28407-28413, 1996.

 

23.  Möhle, R., Green, D., Moore, M.A.S., Nachman, R.L., and Rafii, S. Constitutive Production and Thrombin-induced Release of Vascular Endothelial Growth Factor (VEGF) by Human Megakaryocytes and Platelets. Proc. Natl. Acad. Sci. (USA) 94:663-668, 1997

 

24.  Mohle, R., Moore, M.A.S., Nachman, R.L., Rafii, S.  Transendothelial migration of CD3 and nature hematopoietic cells: An in vitro study using human bone marrow endothelial cell.  Blood. 89: 72-80, 1997.

 

25.  Crombie, R., Silverstein, R.L., Maclow C, Pierce, S.F.A., Nachman, R.L., Laurence, J. Identification of a CD36-related Thrombospondin 1-binding Domain in HIV-1 Envelope Glycoprotein gp120:Relationship to HIV-1-specific Inhibitory Factors in Human Saliva.   J. Exp. Med.  187:25-36, 1998.

 

26.  Hamada, T., Mohle, R., Hesselgesser, J., Hoxie, J., Nachman, R.L., Moore, M.A.S., Rafii, S. Transendothial migration of megakaryocytes in response to stromal derived factor - 1 enhances platelet formation.  J. Exp. Med. 188:539-548, 1998.

 

27.  Simantov, R., Febbraio, M., Crombie, R., Asch, A., Nachman, R.L., Silverstein, R.  Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin -1. J. Clin. Invest.  107:45-52, 2001.

 

28.  Nachman, R.L.  Hypercoagulable States: Challenges and Opportunities. Trans. Am. Clin. Climatolog. Assoc.  112:161-179, 2001

 

29.  Nachman, R.L., and Jaffe, E.A.  Endothelial Cell Culture: Beginnings of Modern Vascular Biology. J. Clin. Invest.  114:1037-1040, 2004

 

30.  Nachman, R.L. Refractory Autoimmune Thrombocytopenia:  Response to Antiplatelet Therapy.  Lancet.  366:1410, 2005.  (Case Report)

 

31.  Nachman, R.L., Rafii, S.  Platelets, Petechiae, and Preservation of the Vascular Wall.  N. Eng.J. Med. 359:1261-1270, 2008. (Review Article)

 

Honors and Awards

Fellow, American College of Physicians
Henry Moses Alumni Award-Montefiore Hospital
President, New York Society for the Study of Blood
Executive Council, American Society of Hematology
J.J. Smith Award for Teaching- Department of Medicine, New York Hospital-CUMC
Stratton Lecturer, American Society of Hematology
Royal Society of Medicine Foundation Award
Institute of Medicine of the National Academy of Sciences
Fellow, New York Academy of Medicine
Fellow, American Association for the Advancement of Science
Maurice R. Greenberg Distinguished Service Award
Robert Williams MD Distinguished Chair of Medicine Award, Association of Professors of Medicine
The New York Weill Cornell Medical Center Alumni Council, NYP-WCMC Service Award