Ralph L. Nachman, M.D.
Dr. Ralph L. Nachman, the Lewis Thomas University Professor and Associate Dean of Clinical Research at Weill Cornell Medical College, is a physician, scientist, educator and administrator. Dr. Nachman has pioneered discoveries in hematology and medical oncology that have furthered the development of new clinical solutions to blood and vascular disorders.
In 1963, he began a more than 40-year career with New York Presbyterian Hospital and Weill Cornell Medical College, beginning as Director of Laboratories for Clinical Pathology, followed by his 25 years as Chief, Division of Hematology and Oncology and 17 years as Chairman of the Department of Medicine at Weill Cornell Medical College and Physician-in-Chief at New York Presbyterian Hospital.
Dr. Nachman has spearheaded multiple endeavors in biomedical research, clinical programs, educational curricula, residency training, fundraising, and quality assurance. His discoveries in vascular biology, and the establishment of the Specialized Center of Research (SCOR) in Thrombosis (National Institutes of Health) at New York-Cornell, led to his performing the first culture of human endothelial cells. This achievement initiated a modern explosion of knowledge in vascular biology. He has published numerous articles in the field of hematology and has lectured around the world. His honors include, The Stratton Award from the American Society of Hematology and the Robert Williams, MD Distinguished Chair of Medicine Award from the Association of Professors of Medicine. He is a member of the Institute of Medicine of the National Academy of Sciences.
1963-1969 Director, Laboratories for Clinical Pathology,
1963-1965 Instructor in Medicine,
1965-1972 Assistant Professor, Medicine,
1968-1972 Associate Professor, Medicine,
1968-1993 Chief, Division of Hematology,
1968-1972 Associate Attending Physician, The
1969-1970 Guest Investigator, The
1972- Attending Physician,
1972- Professor of Medicine,
1974-1978 Vice Chairman, Department of Medicine,
1976-1996 Director, Specialized
1979-1991 Co-director, Rockefeller-Cornell M.D.- Ph.D. Program
1987-1989 Board of Overseers,
1990-2007 Chairman, Department of Medicine,
1992-2007 The E. Hugh Luckey Distinguished Professor in Medicine
2007- Associate Dean, Clinical Research
Insurance Plans Accepted
The following represents most of the managed care plans accepted by this physician. If your insurance carrier does not appear here please feel free to contact this physician or this physician's practice as they may have individual contracts not included on this site.
- AETNA [HMO]
- AETNA [Medicare]
- AETNA [PPO]
- Aetna - Weill Cornell [POS]
- Affinity Health Plan
- Empire Blue Cross/Blue Shield [EPO]
- Empire Blue Cross/Blue Shield [HMO]
- Empire Blue Cross/Blue Shield [Mediblue (Senior)]
- Empire Blue Cross/Blue Shield [PPO]
- Fidelis Care
- Health Insurance Plan of NY (HIP) [Medicaid]
- Health Insurance Plan of NY (HIP)
- Health Insurance Plan of NY (HIP) [Medicare]
- Medicare [Medicare]
- Oxford Health Plans [Medicare Advantage]
- Oxford Health Plans [Freedom]
- Rockefeller University - CoreSource
- United Empire
- United Health Care [Community Plan]
- United Health Care [Medicare]
- United Health Care
Selected peer-reviewed publications (in chronological order).
(Selected from approximately 150 peer-reviewed publications)
1. Nachman, R.L., Hubbard, A., and Ferris B. Iodination of the human platelet membrane: Studies of the major surface glycoprotein. J. Biol. Chem. 248:2928, 1973.
2. Jaffe, E.A., Nachman, R.L., Becker, C., and Minick, C.R. Studies on cultured human endothelial cells derived from umbilical cord veins. J. Clin. Invest. 52:2745, 1973.
3. Jaffe, E.A., Hoyer, L., and Nachman, R.L. Synthesis of AHF antigens by cultured human endothelial cells. J. Clin. Invest. 52:2757, 1973.
4. Nachman, R.L. and Ferris, B. Binding of adenosine diphosphate by isolated membranes from human platelets. J. Biol. Chem. 249:704, 1974.
5. Jaffe, E., Hoyer, L., and Nachman, R.L. Synthesis of von Willebrand factor by cultured human endothelial cells. Proc. Nat. Acad. Sci. 71:1906, 1974.
6. Jaffe, E.A. and Nachman, R.L. Subunit structure of factor VIII antigen synthesized by cultured human endothelial cells. J. Clin. Invest. 56:698-702, 1975.
7. Nachman, R.L., Levine, R., and Jaffe, E.A. Synthesis of factor VIII antigen by cultured guinea pig megakaryocytes. J. Clin. Invest. 60:914-921, 1977.
8. Nachman, R.L., Jaffe, E.A., Miller, C., and Brown, W.T. Structural analysis of Factor VIII antigen in von Wille- brand's disease. Proc. Nat. Acad. Sci. U.S.A. 77:6832-6836, 1980.
9. Leung, L., Kinoshita, T., and Nachman, R.L. Isolation, purification and partial characterization of platelet membrane glycoproteins IIb and IIIa. J. Biol. Chem. 256:1994-1997, 1981.
10. Jaffe, E., Leung, L.L.K., Nachman, R.L., Levin, R., and Mosher, D.F. Thrombospondin is the endogenous lectin of human platelets. Nature 295:246-248, 1982.
11 Leung, L.L.K., and Nachman, R.L. Complex formation of platelet thrombospondin with fibrinogen. J. Clin. Invest. 70:542-549, 1982.
12. Nachman, R.L., Leung, L.L.K., Kloczewiak, M., and Hawiger, J. Complex formation of platelet membrane glycoproteins IIb and IIIa with fibrinogen D domain. J. Biol. Chem. 259:8584-8588, 1984.
13. Silverstein, R.L., Leung, L.L.K., Harpel, P.C., and Nachman, R.L. Complex formation of platelet thrombospondin with plasminogen: modulation of activation by tissue activator. J. Clin. Invest. 74:1625-1633, 1984.
14. Silverstein, R.L., Leung, L.L.K., Harpel, P.C. and Nachman, R.L. Platelet thrombospondin forms a trimolecular complex with plasminogen and histidine rich glycoprotein. J. Clin. Invest. 75:2065-2073, 1985.
15. Nachman, R.L., Hajjar, K.A., Silverstein, R.L., and Dinarello, C. Interleukin-1 induces endothelial cell synthesis of plasminogen activator inhibitor. J. Exp. Med. 163: 1595-1600, 1986.
16. Silverstein, R.L. and Nachman, R.L. Thrombospondin binds to monocytes-macrophages and mediates platelet monocyte adhesion. J. Clin.Invest. 79: 867-87, 1987.
17. Knudsen, B.S., Harpel, P.C., and Nachman, R.L. Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells. J. Clin. Invest. 80:1082-1089, 1987.
18. Konkle, B.A., Shapiro, S.S., Asch, A.S., and Nachman, R.L. Cytokine enhanced expression of Glycoprotein 1ba in human endothelium. J.Biol.Chem. 265:19833-19838,1990.
19. Etingin, O.R., Hajjar, D.P., Hajjar, K.A., Harpel, P.H., and Nachman, R.L. Lipoprotein(a) regulates plasminogen activator inhibitor-1 expression in endothelial cells: A potential mechanism in thrombogenesis. J. Biol. Chem. 266:2459-2465, 1991.
20. Asch, A.S., Tepler, J., Silbiger, S. and Nachman, R.L. Cellular attachment to TSP: Cooperative interactions between receptor systems. J. Biol. Chem. 266:1740-1745,1991.
21. Nachman, R.L. Thrombosis and Atherogenesis: Molecular Connections. Blood 79:1897-1906, 1992.
22. Nicholson, A., Nachman R.L., Altieri, D.C., Summers, B.D., Ruf, W., Edgington, T.S., and Hajjar., D. Effector cell protease receptor-1 is a vascular receptor for coagulation factors Xa. J. Biol. Chem 271:28407-28413, 1996.
23. Möhle, R., Green, D., Moore, M.A.S., Nachman, R.L., and Rafii, S. Constitutive Production and Thrombin-induced Release of Vascular Endothelial Growth Factor (VEGF) by Human Megakaryocytes and Platelets. Proc. Natl. Acad. Sci. (USA) 94:663-668, 1997
24. Mohle, R., Moore, M.A.S., Nachman, R.L., Rafii, S. Transendothelial migration of CD3 and nature hematopoietic cells: An in vitro study using human bone marrow endothelial cell. Blood. 89: 72-80, 1997.
25. Crombie, R., Silverstein, R.L., Maclow C, Pierce, S.F.A., Nachman, R.L., Laurence, J. Identification of a CD36-related Thrombospondin 1-binding Domain in HIV-1 Envelope Glycoprotein gp120:Relationship to HIV-1-specific Inhibitory Factors in Human Saliva. J. Exp. Med. 187:25-36, 1998.
26. Hamada, T., Mohle, R., Hesselgesser, J., Hoxie, J., Nachman, R.L., Moore, M.A.S., Rafii, S. Transendothial migration of megakaryocytes in response to stromal derived factor - 1 enhances platelet formation. J. Exp. Med. 188:539-548, 1998.
27. Simantov, R., Febbraio, M., Crombie, R., Asch, A., Nachman, R.L., Silverstein, R. Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin -1. J. Clin. Invest. 107:45-52, 2001.
28. Nachman, R.L. Hypercoagulable States: Challenges and Opportunities. Trans. Am. Clin. Climatolog. Assoc. 112:161-179, 2001
29. Nachman, R.L., and Jaffe, E.A. Endothelial Cell Culture: Beginnings of Modern Vascular Biology. J. Clin. Invest. 114:1037-1040, 2004
30. Nachman, R.L. Refractory Autoimmune Thrombocytopenia: Response to Antiplatelet Therapy. Lancet. 366:1410, 2005. (Case Report)
31. Nachman, R.L., Rafii, S. Platelets, Petechiae, and Preservation of the Vascular Wall. N. Eng.J. Med. 359:1261-1270, 2008. (Review Article)
Honors and Awards
- Blood Clotting Disorder
- Platelet Disorder
- Bleeding Disorder
- Hypercoagulable State
- Idiopathic Thrombocytopenic Purpura (ITP)
- Von Willebrand's Disease
Contact and Practices
- Medical Oncology
- Internal Medicine
- M.D., Vanderbilt University School of Medicine, 1956