Ralph L. Nachman, M.D.
Medical Oncology
Publications
Selected peer-reviewed publications (in chronological order).
(Selected from approximately 150 peer-reviewed publications)
1. Nachman, R.L., Hubbard, A., and Ferris B. Iodination of the human platelet membrane: Studies of the major surface glycoprotein. J. Biol. Chem. 248:2928, 1973.
2. Jaffe, E.A., Nachman, R.L., Becker, C., and Minick, C.R. Studies on cultured human endothelial cells derived from umbilical cord veins. J. Clin. Invest. 52:2745, 1973.
3. Jaffe, E.A., Hoyer, L., and Nachman, R.L. Synthesis of AHF antigens by cultured human endothelial cells. J. Clin. Invest. 52:2757, 1973.
4. Nachman, R.L. and Ferris, B. Binding of adenosine diphosphate by isolated membranes from human platelets. J. Biol. Chem. 249:704, 1974.
5. Jaffe, E., Hoyer, L., and Nachman, R.L. Synthesis of von Willebrand factor by cultured human endothelial cells. Proc. Nat. Acad. Sci. 71:1906, 1974.
6. Jaffe, E.A. and Nachman, R.L. Subunit structure of factor VIII antigen synthesized by cultured human endothelial cells. J. Clin. Invest. 56:698-702, 1975.
7. Nachman, R.L., Levine, R., and Jaffe, E.A. Synthesis of factor VIII antigen by cultured guinea pig megakaryocytes. J. Clin. Invest. 60:914-921, 1977.
8. Nachman, R.L., Jaffe, E.A., Miller, C., and Brown, W.T. Structural analysis of Factor VIII antigen in von Wille- brand's disease. Proc. Nat. Acad. Sci. U.S.A. 77:6832-6836, 1980.
9. Leung, L., Kinoshita, T., and Nachman, R.L. Isolation, purification and partial characterization of platelet membrane glycoproteins IIb and IIIa. J. Biol. Chem. 256:1994-1997, 1981.
10. Jaffe, E., Leung, L.L.K., Nachman, R.L., Levin, R., and Mosher, D.F. Thrombospondin is the endogenous lectin of human platelets. Nature 295:246-248, 1982.
11 Leung, L.L.K., and Nachman, R.L. Complex formation of platelet thrombospondin with fibrinogen. J. Clin. Invest. 70:542-549, 1982.
12. Nachman, R.L., Leung, L.L.K., Kloczewiak, M., and Hawiger, J. Complex formation of platelet membrane glycoproteins IIb and IIIa with fibrinogen D domain. J. Biol. Chem. 259:8584-8588, 1984.
13. Silverstein, R.L., Leung, L.L.K., Harpel, P.C., and Nachman, R.L. Complex formation of platelet thrombospondin with plasminogen: modulation of activation by tissue activator. J. Clin. Invest. 74:1625-1633, 1984.
14. Silverstein, R.L., Leung, L.L.K., Harpel, P.C. and Nachman, R.L. Platelet thrombospondin forms a trimolecular complex with plasminogen and histidine rich glycoprotein. J. Clin. Invest. 75:2065-2073, 1985.
15. Nachman, R.L., Hajjar, K.A., Silverstein, R.L., and Dinarello, C. Interleukin-1 induces endothelial cell synthesis of plasminogen activator inhibitor. J. Exp. Med. 163: 1595-1600, 1986.
16. Silverstein, R.L. and Nachman, R.L. Thrombospondin binds to monocytes-macrophages and mediates platelet monocyte adhesion. J. Clin.Invest. 79: 867-87, 1987.
17. Knudsen, B.S., Harpel, P.C., and Nachman, R.L. Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells. J. Clin. Invest. 80:1082-1089, 1987.
18. Konkle, B.A., Shapiro, S.S., Asch, A.S., and Nachman, R.L. Cytokine enhanced expression of Glycoprotein 1ba in human endothelium. J.Biol.Chem. 265:19833-19838,1990.
19. Etingin, O.R., Hajjar, D.P., Hajjar, K.A., Harpel, P.H., and Nachman, R.L. Lipoprotein(a) regulates plasminogen activator inhibitor-1 expression in endothelial cells: A potential mechanism in thrombogenesis. J. Biol. Chem. 266:2459-2465, 1991.
20. Asch, A.S., Tepler, J., Silbiger, S. and Nachman, R.L. Cellular attachment to TSP: Cooperative interactions between receptor systems. J. Biol. Chem. 266:1740-1745,1991.
21. Nachman, R.L. Thrombosis and Atherogenesis: Molecular Connections. Blood 79:1897-1906, 1992.
22. Nicholson, A., Nachman R.L., Altieri, D.C., Summers, B.D., Ruf, W., Edgington, T.S., and Hajjar., D. Effector cell protease receptor-1 is a vascular receptor for coagulation factors Xa. J. Biol. Chem 271:28407-28413, 1996.
23. Möhle, R., Green, D., Moore, M.A.S., Nachman, R.L., and Rafii, S. Constitutive Production and Thrombin-induced Release of Vascular Endothelial Growth Factor (VEGF) by Human Megakaryocytes and Platelets. Proc. Natl. Acad. Sci. (USA) 94:663-668, 1997
24. Mohle, R., Moore, M.A.S., Nachman, R.L., Rafii, S. Transendothelial migration of CD3 and nature hematopoietic cells: An in vitro study using human bone marrow endothelial cell. Blood. 89: 72-80, 1997.
25. Crombie, R., Silverstein, R.L., Maclow C, Pierce, S.F.A., Nachman, R.L., Laurence, J. Identification of a CD36-related Thrombospondin 1-binding Domain in HIV-1 Envelope Glycoprotein gp120:Relationship to HIV-1-specific Inhibitory Factors in Human Saliva. J. Exp. Med. 187:25-36, 1998.
26. Hamada, T., Mohle, R., Hesselgesser, J., Hoxie, J., Nachman, R.L., Moore, M.A.S., Rafii, S. Transendothial migration of megakaryocytes in response to stromal derived factor - 1 enhances platelet formation. J. Exp. Med. 188:539-548, 1998.
27. Simantov, R., Febbraio, M., Crombie, R., Asch, A., Nachman, R.L., Silverstein, R. Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin -1. J. Clin. Invest. 107:45-52, 2001.
28. Nachman, R.L. Hypercoagulable States: Challenges and Opportunities. Trans. Am. Clin. Climatolog. Assoc. 112:161-179, 2001
29. Nachman, R.L., and Jaffe, E.A. Endothelial Cell Culture: Beginnings of Modern Vascular Biology. J. Clin. Invest. 114:1037-1040, 2004
30. Nachman, R.L. Refractory Autoimmune Thrombocytopenia: Response to Antiplatelet Therapy. Lancet. 366:1410, 2005. (Case Report)
31. Nachman, R.L., Rafii, S. Platelets, Petechiae, and Preservation of the Vascular Wall. N. Eng.J. Med. 359:1261-1270, 2008. (Review Article)
