Isaac Kligman, M.D.
Reproductive Endocrinology
Publications
Textbooks
1. Rodriguez V, Angulo A, Botero LF and Kligman I (editors): Manual de normas para el manejo de entidades Gineco-Obstetricas (Manual of norms and procedures for the management of gynecological and obstetrical entities). Bogot<: Editorial Universidad Javeriana, 1986.
Chapters
1. Angulo A and Kligman I: Vulvar dystrophies and vulvar carcinoma. In: Rodriguez V, Angulo A, Botero LF and Kligman I (eds.). Manual de normas para el manejo de entidades Gineco-Obstetricas (Manual of norms and procedures for the management of gynecological and obstetrical entities). Bogot<: Editorial Universidad Javeriana, 1986.
2. Angulo A, Botero LF and Kligman I: Carcinoma of the ovary. In: Rodriguez V, Angulo A, Botero LF and Kligman I (eds.). Manual de normas para el manejo de entidades Gineco-Obstetricas (Manual of norms and procedures for the management of gynecological and obstetrical entities). Bogot<: Editorial Universidad Javeriana, 1986.
3. Angulo A, Botero LF and Kligman I: Endometrial carcinoma. In: Rodriguez V, Angulo A, Botero LF and Kligman I (eds.). Manual de normas para el manejo de entidades Gineco-Obstetricas (Manual of norms and procedures for the management of gynecological and obstetrical entities). Bogot<: Editorial Universidad Javeriana, 1986.
4. Angulo A, Botero LF and Kligman I: Invasive carcinoma of the cervix. In: Rodriguez V, Angulo A, Botero LF and Kligman I (eds.). Manual de normas para el manejo de entidades Gineco-Obstetricas (Manual of norms and procedures for the management of gynecological and obstetrical entities). Bogot<: Editorial Universidad Javeriana, 1986.
5. Angulo A, Botero LF, Kligman I, Angel O: Urinary stress incontinence. In: Rodriguez V, Angulo A, Botero LF and Kligman I (eds.). Manual de normas para el manejo de entidades Gineco-Obstetricas (Manual of norms and procedures for the management of gynecological and obstetrical entities). Bogot<: Editorial Universidad Javeriana, 1986.
6. Kligman I and Garcia A: Cytomegalovirus infection during pregnancy. In: Rodriguez V, Angulo A, Botero LF and Kligman I (eds.). Manual de normas para el manejo de entidades Gineco-Obstetricas (Manual of norms and procedures for the management of gynecological and obstetrical entities). Bogot<: Editorial Universidad Javeriana, 1986.
7. Garcia A and Kligman I: Rubella. In: Rodriguez V, Angulo A, Botero LF and Kligman I (eds.). Manual de normas para el manejo de entidades Gineco-Obstetricas (Manual of norms and procedures for the management of gynecological and obstetrical entities). Bogot<: Editorial Universidad Javeriana, 1986.
8. Kligman I Henao O and Garcia A: Ectopic pregnancy. In: Rodriguez V, Angulo A, Botero LF and Kligman I (eds.). Manual de normas para el manejo de entidades Gineco-Obstetricas (Manual of norms and procedures for the management of gynecological and obstetrical entities). Bogot<: Editorial Universidad Javeriana, 1986.
9. Uriza G, Barragan J, Henao O, Garcia A and Kligman I: Septic abortion. In: Rodriguez V, Angulo A, Botero LF and Kligman I (eds.). Manual de normas para el manejo de entidades Gineco-Obstetricas (Manual of norms and procedures for the management of gynecological and obstetrical entities). Bogot<: Editorial Universidad Javeriana, 1986.
10. Uriza G, Henao O, Garcia A and Kligman I: Bleeding during the first trimester of pregnancy. In: Rodriguez V, Angulo A, Botero LF and Kligman I (eds.). Manual de normas para el manejo de entidades Gineco-Obstetricas (Manual of norms and procedures for the management of gynecological and obstetrical entities). Bogot<: Editorial Universidad Javeriana, 1986.
11. Benadiva CA, Kligman I and Rosenwaks Z: Assisted Reproductive Technologies versus Tubal Surgery. In: Sanfilippo JS (ed.) Operative Laparoscopy, 2nd Ed., New York: Springer-Verlag 1995 (in press).
12. Kligman I, Benadiva CA and Rosenwaks Z: Tubal Reconstructive Surgery. In: Mann WJ (ed.) Gynecologic Surgery, New York: Churchill Livingstone 1995 (in press).
Professional Journals
1. Angulo A and Kligman I: Retroperitoneal sacral colpopexy for the correction of the vaginal vault prolapse. Surg Gynecol Obstet 1989; 169:319-323.
2. Kligman I, Glassner M, Storey BT and Kopf GS: Zona pellucida-mediated acrosomal exocytosis in mouse spermatozoa: characterization of an intermediate stage prior to the completion of the acrosome reaction. Develop Biol 1991; 145:344-355.
3. Glassner M, Jones J, Kligman I, Woolkalis M, Gerton G and Kopf GS: Immunocytochemical and biochemical characterization of guanine nucleotide/binding regulatory proteins in mammalian spermatozoa. Develop Biol 1991; 146:438-450.
4. Kligman I, Drachenberg C, Papadimitriou J, Katz E: Immunohistochemical demonstration of nerve fibers in pelvic adhesions. Obstet Gynecol 1993; 82:566-568.
5. Kligman I, Noyes N, Benadiva CA, Rosenwaks Z: Massive deep vein thrombosis in a patient with antithrombin III deficiency undergoing ovarian stimulation for in vitro fertilization. Fertil Steril 63(3):673-676, 1995.
6. Benadiva CA, Kligman I, Davis O and Rosenwaks Z: In vitro fertilization versus tubal surgery: is pelvic reconstructive surgery obsolete? Fertil Steril; Modern Trends, Vol. 64, No.6 Dee 1995 p.1051-61.
7. Benadiva CA, Davis O, Kligman I, Liu H-C and Rosenwaks Z: Clomiphene citrate and hMG: an alternative stimulation protocol for selected failed in vitro fertilization patients. J Assist Reprod Genet. Vol. 12, No.1, 1995 p.8-12.
8. Witkin SS, Kligman I, Grifo JA and Rosenwaks Z: Chlamydia trachomatis detected by the polymerase chain reaction in the cervices of culture-negative women correlated with adverse in vitro fertilization outcome. J Infect Dis June 1995, 171(6) p.1657-9.
9. Witkin SS, Kligman I and Bongiovanni AM: Relationship between asymptomatic male genital tract exposure to chlamydia trachomatis and an autoimmune response to spermatozoa. Hum. Reprod, Nov.1995, 10(11) p.2952-5
10. Witkin SS, Kligman I, Grifo JA and Rosenwaks Z: Ureaplasma urealyticum and mycoplasma hominis detected by the polymerase chain reaction in the cervices of women undergoing in vitro fertilization: prevalence and consequences. J. Assist Reprod Genet, Oct 1995, 12(9) p.610-4
11. Barmat LI, Damario MA, Kowalik A, Kligman I, Davis OK, Rosenwaks Z: Twin gestation occupying separate horns of a bicornuate uterus after in-vitro fertilization and embryo transfer. Hum Reprod Vol.11, No.10, pp2316-18, 1996
12. Witkin SS, Jeremias J, Neuer A, David S, Kligman I, Toth Miklos, Willner E, Witkin K: Immune recognition of the 60kD heat shock protein: implications for subsequent fertility. Inf. Dis M OB GYN 4:152-158, 1996
13. Kligman I, Grifo JA, Witkin SS: Expression of the 60 Kda heat shock protein in peritoneal fluids from women with endometriosis: Implications for endometriosis - associated infertility
14. Katz MD, Kligman I, Cai, LQ, Zhu YS, Fratianni, CM, Zervoudakis I, Rosenwaks Z, Imperato-McGinley J: Paternity by intrauterine insemination in a male pseudohermaphrodite with a 5 "-reductase - 2 gene defect. NEJM Vol.336, No.14 p.994-997, 1997.
15. Spandorfer S., Fierro C, Kligman I, Liu H-C, Neuer A, Witkin SS, Rosenwaks Z, "Endometriosis: Analysis of 1417 consecutive cycles of IVF" Infect Dis Obstet and Gynecol. 1997; 5:202
16. Kligman I, Jeremias J, Rosenwaks Z, Witkin S.S.: Cell-mediated immunity to human and Escherichia coli 60-kDa heat shock protein in women: association with a history of spontaneous abortion and endometriosis. Am J Reprod Immunol (Denmark) July 1998, 40 (1) p32-6
17. Katz MD, Kligman I, Cai LQ, Zhu YS, Fratianni CM, Zervoudakis I, Rosenwaks Z, Imperato-McGinley J. Paternity by intrauterine insemination with sperm from a man with 5alpha-reductase-2 deficiency. N Engl J Med (United States) Apr 3 1997, 336 (14) p994-7
18. Benadiva CA, Davis O, Kligman I, Moomjy M, Liu HC, Rosewaks Z. Withholding gonadotropin administration is an effective alternative for the prevention of ovarian hyperstimulation syndrome. Fertil Steril (United States) Apr 1997, 67 (4) p724-7
19. Benadiva CA, Kligman I, Munne S. Aneuploidy 16 in human embryos increases significantly with maternal age. Fertil Steril (United States) Aug 1996, 66 (2) p248-55
20. Kligman I, Benadiva CA, Alikani M, Munne S. The presence of multinucleated blastomeres in human embryos is correlated with chromosomal abnormalities. Hum Reprod (England) Jul 1996, 11(7) p1492-8
21. Kligman I, Adachi TJ, Katz E, McClamrock HD, Jockle GA, Barakat B. Conserving fertility with early management of cervical pregnancy. A case report. J Reprod Med (United States), Oct 1995, 40 (10) p74-6
Chapters in Textbooks
Benadiva CA, Kligman I and Rosenwaks Z: Assisted Reproductive Technologies versus Tubal Surgery. In: Sanfilippo JS (ed.) Operative Laparoscopy, 2nd Ed., New York: Springer-Verlag 1995
Kligman I, Benadiva CA and Rosenwaks Z: Tubal Reconstructive Surgery. In: Mann WJ (ed.) Gynecologic Surgery, New York: Churchill Livingstone 1995
Professional Journals
Kligman I, Noyes N, Benadiva CA, Rosenwaks Z: Massive deep vein thrombosis in a patient with antithrombin III deficiency undergoing ovarian stimulation for in vitro fertilization. Fertil Steril 63(3):673-676, 1995
Benadiva CA, Kligman I, Davis O and Rosenwaks Z: In vitro fertilization versus tubal surgery: is pelvic reconstructive surgery obsolete? Fertil Steril; Modern Trends, Vol. 64, No.6 Dee 1995 p.1051-61
Benadiva CA, Davis O, Kligman I, Liu H-C and Rosenwaks Z: Clomiphene citrate and hMG: an alternative stimulation protocol for selected failed in vitro fertilization patients. J Assist Reprod Genet. Vol. 12, No.1, 1995 p.8-12
Witkin SS, Kligman I, Grifo JA and Rosenwaks Z: Chlamydia trachomatis detected by the polymerase chain reaction in the cervices of culture-negative women correlated with adverse in vitro fertilization outcome. J Infect Dis June 1995, 171(6) p.1657-9
Witkin SS, Kligman I and Bongiovanni AM: Relationship between asymptomatic male genital tract exposure to chlamydia trachomatis and an autoimmune response to spermatozoa. Hum. Reprod, Nov.1995, 10(11) p.2952-5
Witkin SS, Kligman I, Grifo JA and Rosenwaks Z: Ureaplasma urealyticum and mycoplasma hominis detected by the polymerase chain reaction in the cervices of women undergoing in vitro fertilization: prevalence and consequences. J. Assist Reprod Genet, Oct 1995, 12(9) p.610-4
Witkin SS, Bongiovanni AM, Kligman I, Grifo JA and Rosenwaks Z: Iga antibodies in the cervices of women undergoing in vitro fertilization reactive with synthetic peptide epitopes of the chlamydia trachomatis 60kD heat shock protein. (Submitted 1995)
Barmat LI, Damario MA, Kowalik A, Kligman I, Davis OK, Rosenwaks Z: Twin gestation occupying separate horns of a bicornuate uterus after in-vitro fertilization and embryo transfer. Hum Reprod Vol.11, No.10, pp2316-18, 1996
Witkin SS, Jeremias J, Neuer A, David S, Kligman I, Toth Miklos, Willner E, Witkin K: Immune recognition of the 60kD heat shock protein: implications for subsequent fertility. Inf. Dis M OB GYN 4:152-158, 1996
Kligman I, Grifo JA, Witkin SS: Expression of the 60 Kda heat shock protein in peritoneal fluids from women with endometriosis: Implications for endometriosis - associated infertility
Katz MD, Kligman I, Cai, LQ, Zhu YS, Fratianni, CM, Zervoudakis I, Rosenwaks Z, Imperato-McGinley J: Paternity by intrauterine insemination in a male pseudohermaphrodite with a 5 "-reductase - 2 gene defect. NEJM Vol.336, No.14 p.994-997, 1997
Benadiva CA, Davis OK, Kligman I: Withholding gonadotropin administration is an effective alternative for the prevention of ovarian hyperstimulation syndrome. Fertil & Steril 1997
Abstracts
Benadiva CA, Kligman I, Liu H-C, Neal GS, Sultan KM, Noyes N and Rosenwaks Z: Clomiphene citrate and human menopausal gonadotropin: a rescue stimulation protocol for selected failed in vitro fertilization patients. Poster Presentation: 50th Meeting of the American Fertility Society. San Antonio, Texas, November 5-10, 1994
Benadiva CA, Kligman I, Davis O and Rosenwaks Z: Cumulative probability of pregnancy after in vitro fertilization. Poster Presentation: 50th Meeting of the American Fertility Society. San Antonio, Texas, November 5-10, 1994
Sultan KM, Neal GS, Cholst I, Kligman I, Noyes N, Davis OK and Rosenwaks Z: Uterine factors influence implantation rate in an oocyte donation program. Presented at the 50th Meeting of the American Fertility Society. San Antonio, Texas, November 5-10, 1994
Benadiva CA, Kligman I, Liu H-C, Damario MA, Moomjy M, Moy F and Rosenwaks Z: Implantation efficiency in women over age 40 is independent of the magnitude of the ovarian response. Oral Presentation: Society for Gynecologic Investigation 42nd Annual Meeting. Chicago, Illinois, March 1995
Witkin SS, Kligman I, Grifo JA and Rosenwaks Z: Detection of chlamydia trachomatis by PCR in culture negative women and relation to in vitro fertilization (IVF ) outcome. Oral Presentation: Society for Gynecologic Investigation 42nd Annual Meeting. Chicago, Illinois, March 1995
Witkin SS, Kligman I Grifo JA and Rosenwaks Z: Prevalence of ureaplasma urealyticum detected by the polymerase chain reaction (PCR) in the cervices of women undergoing IVF. IXth World Congress on In Vitro Fertilization and Assisted Reproduction. Vienna, Austria, April 3-7, 1995
Witkin SS, Bongiovanni AM, Kligman I, Grifo JA and Rosenwaks Z: Cervical IgA antibodies reactive with synthetic peptide epitopes of the chlamydia trachomatis 60kd heat shock protein. IXth World Congress on In Vitro Fertilization and Assisted Reproduction. Vienna, Austria, April 3-7, 1995
Witkin SS, Kligman I, Grifo JA and Rosenwaks Z: IVF failure in chlamydia trachomatis culture-negative women who are positive for chlamydia by the polymerase chain reaction (PCR). IXth World Congress on In Vitro Fertilization and Assisted Reproduction. Vienna, Austria, April 3-7, 1995
Damario MA, Moomjy M, Moy F, Benadiva CA, Kligman I, Davis OK and Rosenwaks Z: Enhanced in vitro fertilization pregnancy rates are seen following delay of gonadotropin stimulation in patients on gonadotropin releasing-hormone agonist GnRHa therapy. (Submitted 1995)
Kligman I, Alikani M, Cohen J and MunnJ S: The presence of multinucleated blastomeres correlates with chromosomal abnormalities in human embryos. Presented at the American Society for Reproductive Medicine. Seattle, Washington, October 7-12, 1995
Witkin SS, Kligman I and Bongiovanni AM: Infection-related autoimmune response to sperm: IgA antibodies to chlamydia trachomatis in semen of asymptomatic men and antisperm antibodies on the surface of their motile sperm. (Submitted 1995)
Kligman I, Grifo JA and Witkin SS: Detection of the 60kd heat shock protein (HSP60) and interferon-y in peritoneal fluids from women undergoing a diagnostic laparoscopy. (Submitted 1995)
Kligman I, Rosenwaks Z, Witkin SS: Cell-mediated immune responses to T and B cell mitogens, candida albicans and heat shock proteins in IVF patients. (Submitted 1996)
Kowalik A, Barmat L, Spandorfer S, Kligman I, Rosenwaks Z: Lupron flare effect as a predictor of stimulation response and IVF cycle outcome. (Submitted 1996)
SD Spandorfer, OK Davis, Kligman I, LI Barmat, HC Liu, A Kowalik Z Rosenwaks: The linear increase in pregnancy loss after clinical pregnancy in IVF is related to chromosomal abnormalities. Oral presentation - 53 rd annual meeting of the ASRM, October 18-22, 1997, Cincinnati, Ohio
Kligman I, Rosenwaks Z, Witkin S: "Cell-mediated immunity to human 60 KD heat shock protein (HSP60) in women: association with spontaneous abortion. " 53rd annual meeting of the ASRM, October 18-22, 1997, Cincinnati, Ohio
SD Spandorfer, Sills ES, Chung PH, Davis OK, Kligman I, Liu HC, Rosenwaks Z: Poster - Periovulatory hormonal patterns are not predictive of IVF outcome. 53rd annual meeting of the ASRM, October 18-22, 1997, Cincinnati, Ohio
Principal Investigator, Serono Research Grant. Study of the Ovarian Response to Exogenous Gonadotropins in B Thalassemic Patients. (1995)
1. Ariza A, Garcia A and Kligman I: Antepartum fetal heart rate monitoring: experience at the Hospital San Ignacio. Presented at the Annual Meeting of the Colombian Society of Obstetrics and Gynecology. Cali, Colombia, 1985.
2. Urdinola J, Rodriguez V and Kligman I: The use of prostaglandin E 2 for the induction of labor, a collaborative study. Presented at the Annual Meeting of the Colombian Society of Obstetrics and Gynecology. Cali, Colombia, 1985.
3. Quijano H, Angulo A and Kligman I: Collaborative study on the incidence of gynecological malignancies in Bogot<, Colombia: 1981-1985. Presented at the Annual Meeting of the Colombian Society of Obstetrics and Gynecology. Cali, Colombia, 1985.
4. Kligman I, Benadiva CA, Blasco L, Mastroianni L, Jr. and Flickinger GL: Different timing of hCG administration after an endogenous LH surge affects fertilization and outcome of IVF. Presented at the VIth World Congress of IVF. Jerusalem, Israel, April 1989.
5. Benadiva CA, Kligman I, Liu H-C, Neal GS, Sultan KM, Noyes N and Rosenwaks Z: Clomiphene citrate and human menopausal gonadotropin: a rescue stimulation protocol for selected failed in vitro fertilization patients. Poster Presentation: 50th Meeting of the American Fertility Society. San Antonio, Texas, November 5-10, 1994.
6 Benadiva CA, Kligman I, Davis O and Rosenwaks Z: Cumulative probability of pregnancy after in vitro fertilization. Poster Presentation: 50th Meeting of the American Fertility Society. San Antonio, Texas, November 5-10, 1994.
7. Sultan KM, Neal GS, Cholst I, Kligman I, Noyes N, Davis OK and Rosenwaks Z: Uterine factors influence implantation rate in an oocyte donation program. Presented at the 50th Meeting of the American Fertility Society. San Antonio, Texas, November 5-10, 1994.
8. Benadiva CA, Kligman I, Liu H-C, Damario MA, Moomjy M, Moy F and Rosenwaks Z: Implantation efficiency in women over age 40 is independent of the magnitude of the ovarian response. Oral Presentation: Society for Gynecologic Investigation 42nd Annual Meeting. Chicago, Illinois, March 1995.
9. Witkin SS, Kligman I, Grifo JA and Rosenwaks Z: Detection of chlamydia trachomatis by PCR in culture negative women and relation to in vitro fertilization (IVF ) outcome. Oral Presentation: Society for Gynecologic Investigation 42nd Annual Meeting. Chicago, Illinois, March 1995.
10. Witkin SS, Kligman I Grifo JA and Rosenwaks Z: Prevalence of ureaplasma urealyticum detected by the polymerase chain reaction (PCR) in the cervices of women undergoing IVF. IXth World Congress on In Vitro Fertilization and Assisted Reproduction. Vienna, Austria, April 3-7, 1995.
11. Witkin SS, Bongiovanni AM, Kligman I, Grifo JA and Rosenwaks Z: Cervical IgA antibodies reactive with synthetic peptide epitopes of the chlamydia trachomatis 60kd heat shock protein. IXth World Congress on In Vitro Fertilization and Assisted Reproduction. Vienna, Austria, April 3-7, 1995.
12. Witkin SS, Kligman I, Grifo JA and Rosenwaks Z: IVF failure in chlamydia trachomatis culture-negative women who are positive for chlamydia by the polymerase chain reaction (PCR). IXth World Congress on In Vitro Fertilization and Assisted Reproduction. Vienna, Austria, April 3-7, 1995.
13. Damario MA, Moomjy M, Moy F, Benadiva CA, Kligman I, Davis OK and Rosenwaks Z: Enhanced in vitro fertilization pregnancy rates are seen following delay of gonadotropin stimulation in patients on gonadotropin releasing-hormone agonist GnRHa therapy. (Submitted 1995).
14. Kligman I, Alikani M, Cohen J and MunnJ S: The presence of multinucleated blastomeres correlates with chromosomal abnormalities in human embryos. Presented at the American Society for Reproductive Medicine. Seattle, Washington, October 7-12, 1995.
15. Witkin SS, Kligman I and Bongiovanni AM: Infection-related autoimmune response to sperm: IgA antibodies to chlamydia trachomatis in semen of asymptomatic men and antisperm antibodies on the surface of their motile sperm. (Submitted 1995).
16. Kligman I, Grifo JA and Witkin SS: Detection of the 60kd heat shock protein (HSP60) and interferon-y in peritoneal fluids from women undergoing a diagnostic laparoscopy. (Submitted 1995).
17. Kligman I, Rosenwaks Z, Witkin SS: Cell-mediated immune responses to T and B cell mitogens, candida albicans and heat shock proteins in IVF patients. (Submitted 1996)
18. Kowalik A, Barmat L, Spandorfer S, Kligman I, Rosenwaks Z: Lupron flare effect as a predictor of stimulation response and IVF cycle outcome. (Submitted 1996)
19. Spandorfer SD, Davis OK, Kligman I, Barmat LI, Liu HC, Kowalik A Rosenwaks Z: The linear increase in pregnancy loss after clinical pregnancy in IVF is related to chromosomal abnormalities. Oral presentation - 53 rd annual meeting of the ASRM, October 18-22, 1997, Cincinnati, Ohio
20. Kligman I, Rosenwaks Z, Witkin S: "Cell-mediated immunity to human 60 KD heat shock protein (HSP60) in women: association with spontaneous abortion. " 53rd annual meeting of the ASRM, October 18-22, 1997, Cincinnati, Ohio
21. SD Spandorfer, Sills ES, Chung PH, Davis OK, Kligman I, Liu HC, Rosenwaks Z: Poster - Periovulatory hormonal patterns are not predictive of IVF outcome. 53rd annual meeting of the ASRM, October 18-22, 1997, Cincinnati, Ohio
22. Kligman I, Rosenwaks Z, Witkin SS, Cell-Mediated immunity to human 60 KD heat shock protein (HSP60) in women: association with spontaneous abortion. The Center for Reproductive Medicine and Infertility, Department of OB/GYN, Cornell University Medical College, New York, NY
