Daniel M. Knowles, M.D.

Anatomic Pathology and Clinical Pathology



Said J, Cesarman E, Knowles DM: Lymphadenopathy and the lymphoid neoplasms associated with HIV infection and other causes of immunosuppression. In: Knowles’ Neoplastic Hematopathology. 3rd Ed. Orazi A, Weiss L, Foucar K, Knowles DM (Eds). Lippincott Williams and Wilkins, Philadelphia, 2013.

Wang, YL, Cesarman E, Knowles DM: Antigen receptor genes: Structure, function, and molecular analysis in clinical applications. In: Knowles’ Neoplastic Hematopathology. 3rd Ed Orazi A, Weiss L, Foucar K, Knowles DM (Eds). Lippincott Williams and Wilkins, Philadelphia, 2013.


Boiocchi L, Mathew S, Gianelli U, Iurlo A, Radice T, Barouk-Fox S, Knowles DM, Orazi A: Morphologic and cytogenetic differences between post-polycythemic myelofibrosis and primary myelofibrosis in fibrotic stage.Mod Pathol. 2013 Dec;26(12):1577-85.

Boiocchi L, Espinal-Witter R, Geyer JT, Steinhilber J, Bonzheim I, Knowles DM, Fend F, Orazi A: Development of monocytosis in patients with primary myelofibrosis indicates an accelerated phase of the disease. Mod Pathol. 2013 Feb;26(2):204-12.

Geyer JT, Verma S, Mathew S, Wang YL, Racchumi J, Espinal-Witter R, Subramaniyam S, Knowles DM, Orazi A: Bone marrow morphology predicts additional chromosomal abnormalities in patients with myelodysplastic syndrome with del. Hum Pathol. 2013 Mar;44(3):346-56.

Cols M, Barra CM, He B, Puga I, Xu W, Chiu A, Tam W, Knowles DM, Dillon SR, Leonard JP, Furman RR, Chen K, Cerutti A: Stromal endothelial cells establish a bidirectional crosstalk with chronic lymphocytic leukemia cells through the TNF-related factors BAFF, APRIL, and CD40L. J Immunol. 2012 Jun 15;188(12):6071-83.

Boiocchi L, Witter RE, He B, Subramaniyam S, Mathew S, Nie K, Cerutti A, Coleman M, Knowles DM, Orazi A, Tam W: Composite chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma are biclonal lymphomas: a report of two cases. Am J Clin Pathol. 2012 Apr;137(4):647-59.

Prakash S, Hoffman R, Barouk S, Wang YL, Knowles DM, Orazi A: Splenic extramedullary hematopoietic proliferation in Philadelphia chromosome-negative myeloproliferative neoplasms: heterogeneous morphology and cytological composition.  Mod Pathol. 2012 Jun;25(6):815-27.

Puga I, Cols M, Barra CM, He B, Cassis L, Gentile M, Comerma L, Chorny A, Shan M, Xu W, Magri G, Knowles DM, Tam W, Chiu A, Bussel JB, Serrano S, Lorente JA, Bellosillo B, Lloreta J, Juanpere N, Alameda F, Baró T, de Heredia CD, Torán N, Català A, Torrebadell M, Fortuny C, Cusí V, Carreras C, Diaz GA, Blander JM, Farber CM, Silvestri G, Cunningham-Rundles C, Calvillo M, Dufour C, Notarangelo LD, Lougaris V, Plebani A, Casanova JL, Ganal SC, Diefenbach A, Aróstegui JI, Juan M, Yagüe J, Mahlaoui N, Donadieu J, Chen K, Cerutti A: B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen. Nat Immunol. 2011 Dec 25;13(2):170-80.

Dornfeld K, Gessert CE, Renier CM, McNaney DD, Urias RE, Knowles DM, Beauduy JL, Widell SL, McDonald BL: Differences in breast tissue oxygenation following radiotherapy.  Radiother Oncol. 2011 Aug;100(2):289-92.

Chiu A, Czader M, Cheng L, Hasserjian RP, Wang M, Bhagavathi S, Hyjek EM, Al-Ahmadie H, Knowles DM, Orazi A: Clonal X-chromosome inactivation suggests that splenic cord capillary hemangioma is a true neoplasm and not a subtype of splenic hamartoma.  Mod Pathol. 2011 Jan;24(1):108-16.

Nie K, Zhang T, Allawi H, Gomez M, Liu Y, Chadburn A, Wang YL, Knowles DM, Tam W: Epigenetic down-regulation of the tumor suppressor gene PRDM1/Blimp-1 in diffuse large B cell lymphomas: a potential role of the microRNA let-7. Am J Pathol. 2010 Sep;177(3):1470-9.

Chen YT, Chadburn A, Lee P, Hsu M, Ritter E, Chiu A, Gnjatic S, Pfreundschuh M, Knowles DM, Old LJ: Expression of cancer testis antigen CT45 in classical Hodgkin lymphoma and other B-cell lymphomas.  Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3093-8.

Song Z, Lu P, Furman RR, Leonard JP, Martin P, Tyrell L, Lee FY, Knowles DM, Coleman M, Wang YL: Activities of SYK and PLCgamma2 predict apoptotic response of CLL cells to SRC tyrosine kinase inhibitor dasatinib. Clin Cancer Res. 2010 Jan 15;16(2):587-99.

Ouansafi I, He B, Fraser C, Nie K, Mathew S, Bhanji R, Hoda R, Arabadjief M, Knowles D, Cerutti A, Orazi A, Tam W. Transformation of follicular lymphoma to plasmablastic lymphoma with c-myc gene rearrangement. Am J Clin Pathol. 2010 Dec;134(6):972-81.

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