Darius Paduch, M.D., Ph.D.

Urology
Darius Paduch

 

Dr. Darius A. Paduch, MD, PhD is an Associate Professor of Urology and Reproductive Medicine at Weill Cornell Medical College in New York City, NY, USA. He is an internationally recognized expert in genetics and reproductive endocrinology of male infertility, sexual medicine, virology, and hypogonadism.

Dr. Paduch received his medical degree from the Medical Academy of Lodz, Poland, and his PhD in molecular microbiology from the Polish Academy of Sciences. He finished his residency in urology at Oregon Health Sciences University in Portland, Oregon, followed by a post-doctoral fellowship in andrology and male infertility at the Center for Male Reproductive Medicine, at Weill Cornell Medical College and the Population Council on the campus of Rockefeller University, in New York City. He subsequently joined the faculty as a clinician-scientist at Weill Cornell Medical College, where he has been an academic faculty member since 2003.

Dr. Paduch is Associate Research Director of the Fellowship Program in Male Infertility and Andrology, and is a certified Laboratory Director in Endocrinology, Andrology, Bacteriology, and Genetic Testing.

His clinical and translational research interests focus on the preservation of fertility in adolescents with Klinefelter Syndrome, genetics of male infertility and testicular failure, and the role of antivirals on spermatogenesis and sperm chromatin damage. He has made significant contributions to advance our understanding of neurobiology of ejaculatory and orgasmic dysfunction in men and has developed new methods to measure arousal using ultrasonography. His research has led to the development of clinical trials to measure the effects of testosterone replacement on ejaculatory dysfunction.

Dr. Paduch has published over 80 peer reviewed journal articles, 8 book chapters, and has given numerous invited lectures in the United States, Europe, and New Zealand.

He specializes in treating male children, adolescents and adults with varicocele, infertility, Klinefelter Syndrome, low testosterone, and sexual dysfunction.

A retired captain in the US Army, Dr. Paduch is an avid boater, fisherman and crossbow hunter in his spare time.

 

Appointments can be scheduled by calling Dr. Paduch's office at 212-746-5309.

EDUCATION:

· B.S., Biochemistry, Copernicus Gymnasium, Kolobrzeg, Poland

1982 – 1986

· M.D. Degree, Medical Academy of Lodz, Poland,

1986 – 1993, 1990 – 1993 MD/PhD Program

· Ph.D. in Applied Medical Sciences – Molecular Microbiology, Medical Academy of Lodz, Poland, Polish Mother's Institute for Medical Research, Lodz, Poland

1990 – 2002,

· Residency in Urology, Oregon Health and Science University, Portland, OR

1996 – 2002

· Fellowship in Male Infertility and Andrology, Weill Medical College of Cornell University, New York, NY

2003-2005

· Postdoctoral Fellowship in Molecular Reproductive Biology, Center for Biomedical Research, Population Council, New York, NY

2003 – 2005

WORK EXPERIENCE:

· Instructor in Pediatric Surgery and Urology, Co-Director Center for Adolescent Andrology, Staff Scientist, Dept. of Pediatric Surgery, Polish Mother's Memorial Hospital, Lodz, Poland

1993 –1995

· Intern in Internal Medicine, Mercy Catholic Medical Center, Darby, PA

1995 – 1996

· Resident in Urology, Oregon Health and Science University, Portland, OR

1996 – 2002,

· Assistant Professor of Surgery, Div. of Urology, Oregon Health and Science University, Portland, OR

2002 – 2003,

· Instructor in Urology, Postdoctoral Fellow, Dept. of Urology, Weill Medical College of Cornell University, New York, NY

2003 – 2005

· Assistant Professor of Urology and Reproductive Medicine, Brady Urologic Health Center, Cornell Institute for Reproductive Medicine, New York, NY

2005 – present

· Staff Scientist, Center for Biomedical Research, Population Council, New York, NY

2005-present

· New York State Department of Health Certified Genetic Laboratory Assistant Director, Department of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, NY

2007-present

· Associate Research Director of Fellowship Program in Male Infertility and Andrology, Department of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, NY

2008-present

· Consultant and President, Chief Scientist, Consulting Research Services, Inc, Red Bank, NJ

2009-present

AWARDS and HONORS:

· 2nd Place, Best Research, AUA Foundation Research Forum, Chicago, 2009

· Society for Study of Male Reproduction AUA 2009 Research Forum Scholar, Chicago, 2009

· Cook Urology Travel Award, American Society of Andrology, Seattle, 2005

· In-Training Award of American Society for Reproductive Medicine, Philadelphia, 2004

· New Investigator Award, American Society of Andrology, Baltimore, 2004

· Thomas C. Chang Trainee Travel Award, American Society of Andrology, Baltimore, 2004

· Miley B. Wesson Western Section AUA Award, Anchorage, 2001

· Society for Male Reproduction and Urology Traveling Award, Orlando, 2001

· Scholar in Marine Biological Laboratory (Frontiers in Reproduction), Woods Hole, 2001

· Pfizer Scholars in Urology Award, Portland, 2001

· C.V. Hodges Best Resident Paper, Portland, 1999

· AAP, Section on Urology; 1st Place in Clinical Research Prize Award, San Francisco, 1995

BOARDS and COMMITEES:

· American Society of Andrology Exam Committee, 2007- present

· Society Assisted Reproductive Technology Research Committee Board Member, 2007-2010

MEMBERSHIP IN PROFESSIONAL ORGANIZATIONS:

· American Urological Association

· American Society for Reproductive Medicine

· American Society of Andrology

· Endocrine Society

· Sexual Medicine Society of North America

· Society for Male Reproduction and Urology

· Society for the Study of Male Reproduction

SPECIAL TRAINING:

· NIH, NIDDK Clinical research in Kidney and Urologic Diseases course, Washington, DC, 2004

· Responsible Conduct of Research certificate, IRB, Weill Medical College, NYC, NY, 2004

· Laboratory Safety Course, Rockefeller University, NYC, NY, 2003

· Laboratory Radiation Safety Course for PI, Weill Medical College, NYC, NY, 2003

· Research Integrity Training for Principal Investigators, 2008

LICENSURE:

State of New York, unlimited, current, active, 227386-1,

State of Oregon, unlimited, current, inactive, MD24101,

DEA certificate, current, BPXXXXXX,

FUNDING:

Role: Principal Investigator,

Title: Magnetic resonance spectroscopy in assessment of testicular function in adolescents and men with Klinefelter Syndrome.

Source: Klinefelter Syndrome and Associates

Period: 2007-2008

Role: Principal Investigator,

Title: Use of Ultrasound in Evaluation of Orgasmic and Ejaculatory Dysfunction in Men – Validation of New Method

Source: Eli Lilly and Company

Period: 1-2009 to 1-2010

Role: Principal Investigator and Program Director for fellowship training grant to Dr. Laurent Vaucher

Title: Estradiol signaling through GPR30 membrane receptor and its role in steroidogenesis.

Source: SICPA Fondation, Societe Academique Vaudoise Fund and Pierre Decker Fund

Period: 2007-2008

Insurances

Insurance Plans Accepted

The following represents most of the managed care plans accepted by this physician. If your insurance carrier does not appear here please feel free to contact this physician or this physician's practice as they may have individual contracts not included on this site.

  • AETNA [HMO]
  • AETNA [PPO]
  • Aetna - Weill Cornell [POS]
  • Empire Blue Cross/Blue Shield [PPO]
  • Empire Blue Cross/Blue Shield [EPO]
  • Medicaid
  • Rockefeller University - CoreSource

Publications

PUBLICATIONS and PUBLISHED PEER REVIEWED ABSTRACTS:

1. Valerio M, Lamy O, Paduch DA, Jichlinski P,Vaucher L. [ROLE OF THE UROLOGIST IN THE SCREENING OF BONE DISEASES]. Rev Med Suisse. 2010 Dec 8;6(274):2340, 2342-5. French.

2. Hellstrom WJ, Paduch D, Donatucci CF. Importance of hypogonadism and testosterone replacement therapy in current urologic practice: a review. Int Urol Nephrol. 2010 Dec 9.

  1. Ramkumar A, Lal A, Paduch DA, Schlegel PN. An ultrasonically actuated silicon-microprobe-based testicular tubule assay. IEEE Trans Biomed Eng. 2009 Nov;56(11):2666-74
  1. Vaucher L, Bolyakov A, Paduch DA. Evolving techniques to evaluate ejaculatory function. Curr Opin Urol. 2009 Nov;19(6):606-14. Review.
  1. Stahl PJ, Mielnik A, Margreiter M, Marean MB, Schlegel PN, Paduch DA. Diagnosis of the gr/gr Y chromosome microdeletion does not help in the treatment of infertile American men. J Urol. 2011 Jan;185(1):233-7. Epub 2010 Nov 13.
  1. Stahl PJ, Masson P, Mielnik A, Marean MB, Schlegel PN, Paduch DA. A decade of experience emphasizes that testing for Y microdeletions is essential in American men with azoospermia and severe oligozoospermia. Fertil Steril. 2009 Nov 5.

  1. Paduch DA, Bolyakov A, Cohen P, Travis A. Reproduction in men with Klinefelter syndrome: the past, the present, and the future. Semen Reprod Med. 2009 Mar;27(2):137-48. Epub 2009 Feb 26. Review.
  1. Vaucher L, Mielnik A, Gimenez E, Schlegel PN, Paduch DA. MOLECULAR HISTOPATHOLOGY-TOWARD UNIFORM CLASSIFICATION OF TESTICULAR BIOPSIES. Journal of Urology 2009;181:1893.
  1. Vaucher L, Carreras E, Mielnik A, Schlegel PN, Paduch DA. OVER EXPRESSION OF AROMATASE CYP19 IN HUMAN TESTIS IS MOST LIKELY REASON FOR HYPOGONADISM IN MEN WITH KLINEFELTER SYNDROME. Journal of Urology 2009;181:1886.
  1. Tanrikut C, Feldman AS, Altemus M, Paduch DA, Schlegel PN. Adverse effect of paroxetine on sperm. Fertil Steril 2009.Paduch DA, Bolyakov A, Cohen P, Travis A. Reproduction in men with Klinefelter syndrome: the past, the present, and the future. Semin Reprod Med 2009;27:137-48.
  1. Mielnik A, Gimenez E, Schlegel PN, Paduch DA. REAL-TIME PCR ANALYSIS DETECTION OF AZF MICRODELETIONS: A RAPID AND ACCURATE METHOD FOR INFERTILITY SCREENING. Journal of Urology 2009;181:2167.
  1. Kim HH, Goldstein M, Paduch DA. SPERM APOPTOSIS IS ACTIVATED THROUGH THE MITOCHONDRIAL PATHWAY. Journal of Urology 2009;181:1897.
  1. Gimenez E, Bolyakov A, Herman M, Kiper J, Paduch DA. INFERTILITY, OBESITY, AND HYPOGONADISM ARE SIGNIFICANT FACTORS FOR OSTEOPOROSIS IN YOUNG MEN. Journal of Urology 2009;181:2163.
  1. Stahl PJ, Mielnik A, Marean MB, Schlegel PN, Paduch DA. The GR/GR polymorphism is clinically irrelevant. Journal of Urology 2008;179:594-5.
  1. Stahl PJ, Mielnik A, Marean M, Schlegel PN, Paduch DA. Identification of candidate genes for individual steps in spermatogenesis. Journal of Urology 2008;179:617-.
  1. Sarafoglou K, Hoffman G. Pediatric endocrinology and inborn errors of metabolism. New York: McGraw-Hill; 2008.
  1. Paduch DA, Fine RG, Bolyakov A, Kiper J. New concepts in Klinefelter syndrome. Curr Opin Urol 2008;18:621-7.
  1. Paduch DA, Bolyakov A, Pacik D. Syndrom panevni bolesti u muzu a sexualni dysfunkce. [Chronic pelvic pain syndrome and sexual dysfunction]. Urol List 2008;6:18-29.
  1. Paduch DA, Bolyakov A, Kiper J, Pacik D. Osteopenie a osteoporoza u infertilnich mladych muzu trpicich sexualni dysfunkci [Osteopenia and osteoporosis in young men presenting with infertility or sexual dysfunction - clinical experience.]. Urol List 2008;6:40-54.
  1. Paduch DA. Transient asynchronous testicular growth in adolescent males with a varicocele - Comment. Journal of Urology 2008;180:1114-.
  1. Muller A, Tal R, Donohue JF, et al. The effect of hyperbaric oxygen therapy on erectile function recovery in a rat cavernous nerve injury model. J Sex Med 2008;5:562-70.
  1. Mulhall JP, Muller A, Donohue JF, et al. The functional and structural consequences of cavernous nerve injury are ameliorated by sildenafil citrate. Journal of Sexual Medicine 2008;5:1126-36.
  1. Kim HH, Schlegel PN, Paduch DA. Chroma-sort Select (TM): A novel sorting technology that allows for highly efficient selection of sperm without chromatin damage. Journal of Urology 2008;179:617-8.
  1. Fine RG, Paduch DA. Preservation of spermatogenesis in adolescents with Klinefelter syndrome. Journal of Urology 2008;179:98-9.
  1. Bayne A, Paduch D, Skoog SJ. Pressure, fluid and anatomical characteristics of abdominoscrotal hydroceles in infants. J Urol 2008;180:1720-3; discussion 3.
  1. Tanrikut C, Hardy DO, Ge R, et al. 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) isozymes in the human testis. Journal of Andrology 2007:65-.
  1. Paduch DA, Mielnik A, Schlegel PN, Hardy M. Estrogens in testicular physiology: GPR30 - A novel G-protein estradiol receptor conveys estradiol action on early spermatogonial divisions and spermiogenesis in rodents and humans. Fertility and Sterility 2007;88:S368-S.
  1. Paduch DA, Kiper J. Efficacy of clomid, arimidex, and androgel in normalizing testosterone in young hypogonadal men presenting with infertilityand sexual dysfunction. Fertility and Sterility 2007;88:S75-S.
  1. Paduch DA. Viral lower urinary tract infections. Current Prostate Reports 2007;5:40-50.
  1. Oktem O, Paduch DA, Xu K, Mielnik A, Oktay K. Normal female phenotype and ovarian development despite the ovarian expression of the sex-determining region of Y chromosome (SRY) in a 46,XX/69,XXY diploid/triploid mosaic child conceived after in vitro fertilization-intracytoplasmic sperm injection. J Clin Endocrinol Metab 2007;92:1008-14.
  1. Herman MP, Paduch DA. High prevalence of osteopenia and osteoporosis in young hypogonadal men with infertility and sexual dysfunction. Journal of Urology 2007;177:639-.
  1. Tal R, Donohue JF, Akin-Olugbade Y, et al. The effect of hyperbaric oxygen therapy on erectile function recovery in the rat cavernous nerve injury model. Journal of Urology 2006;175:223-4.
  1. Paduch DA. Testicular cancer and male infertility. Current Opinion in Urology 2006;16:419-27.
  1. Monoski MA, Paduch DA, Goldstein M. High grade varicocele and low sperm density are associated with high degree of sperm chromatin damage in infertile men. Journal of Urology 2006;175:526-.
  1. Margreiter M, Paduch DA, Mielnik A, Schlegel PN. Defective recombination: The role of MLH3 in infertile men. Fertility and Sterility 2006;86:S13-S.
  1. Margreiter M, Paduch DA, Mielnik A, Schlegel PN. The role of gr/gr deletion in infertile men still remains to be answered. Journal of Urology 2006;175:524-5.
  1. Donohue JF, Tal R, Akin-Olugbade Y, et al. Sildenafil and cavernous nerve injury in the rat: Defining the optimal dosing and timing regimen. Journal of Urology 2006;175:327-8.
  1. Schlegel PN, Paduch DA. Yet another test of sperm chromatin structure. Fertility and Sterility 2005;84:854-9.
  1. Patton PE, Battaglia DE. Office andrology. Totowa, N.J.: Humana Press; 2005.
  1. Paduch DA, Niedzielski J. Biomedical materials. Part II: : Assessment of the adhesion of Escherichia coli to biomedical materials in an original dynamic flow system. Polish Surgery [Chirurgia Polska] 2005;7:252-66.
  1. Paduch DA, Mielnik A, Schlegel PN. A specific mutation in the USP26 gene is associated with poor sperm recovery in men with non-obstructive azoospermia. Fertility and Sterility 2005;84:S76-S.
  1. Paduch DA, Mielnik A, Schlegel PN. Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadism. Reproductive Biomedicine Online 2005;10:747-54.
  1. Paduch DA, Mielnik A, Schlegel PN. Methylation specific pcr for diagnosis of Klinefelter syndrome. Journal of Urology 2005;173:448-9.
  1. Paduch DA. The journey of a trainee. Journal of Andrology 2005;26:176-7.
  1. Kuzanski WR, Olszewski A, Paduch DA, Niedzielski JK. Some make it cold, some make it hot - Results of high resolution thermography in adolescents with grade III varicocele. Journal of Urology 2005;173:449-.
  1. Donohue JF, Mullerad M, Paduch DA, Li PS, Scardino PT, Mulhall JP. The functional and structural consequences of cavernous nerve injury in the rat model are ameliorated by sildenafil citrate. Bju International 2005;95:44-.
  1. Donohue JF, Mullerad M, Paduch DA, et al. The functional and structural consequences of cavernous nerve injury in the rat model are ameliorated by sildenafil citrate. Journal of Urology 2005;173:285-.
  1. Donohue JF, Mullerad M, Kobylarz KA, Li PS, Scardino PT, Mulhall JP. Short-term erectile function preservation using daily sildenafil citrate in a rat cavernous nerve injury model is not mediated through neuromodulation. Journal of Urology 2005;173:285-.
  1. Przewratil P, Paduch DA, Kobos J, Niedzielski J. Expression of estrogen receptor alpha and progesterone receptor in children with undescended testicle previously treated with human chorionic gonadotropin. Journal of Urology 2004;172:1112-6.
  1. Paduch DA, Skoog SJ. Diagnosis, evaluation and treatment of adolescent varicocele. ScientificWorldJournal 2004;4 Suppl 1:263-78.
  1. Paduch DA, Mielnik AN, Schlegel PN. Novel mutations in testis specific ubiquitin protease 26 (USP26) in infertile males. Journal of Urology 2004;171:370-1.
  1. Paduch DA, Mielnik A, Schlegel PN. Molecular diagnosis of chromosomal aneuploidy including Klinefelter syndrome. Fertility and Sterility 2004;82:S2-S.
  1. Paduch DA, Mielnik A, Schlegel PN. From the oocyte or the sperm? The origin of the X chromosome in Klinefelter syndrome. Journal of Andrology 2004:89-.
  1. Janoff DM, Davol P, Hazzard J, Lemmers MJ, Paduch DA, Barry JM. Computerized tomography with 3-dimensional reconstruction for the evaluation of renal size and arterial anatomy in the living kidney donor. Journal of Urology 2004;171:27-30.
  1. Paduch DA, Fuchs EF. Single surgeon experience with more than 2,200 vasectomy reversals - Demographic data. Fertility and Sterility 2003;80:S230-S1.
  1. Paduch DA, Davol P, Fuchs EF, Niedzielski J. Varicocele repair in adolescents - Are we preserving fertility? Journal of Urology 2002;167:311-.
  1. Paduch DA, Skoog SJ. Current management of adolescent varicocele. Rev Urol 2001;3:120-33.
  1. Paduch DA, Niedzielski J, Fuchs E. Varicocele causes progressive and time dependent impairment of spermatogenesis. Fertility and Sterility 2001;76:S256-S.
  1. Paduch DA, Niedzielski J, Fuchs E. Prevention of male infertility - experience with more than 600 young men with varicocele. Fertility and Sterility 2001;76:S48-S.
  1. Paduch DA, Barry JM, Arsanjani A, Lemmers MJ. Indication, surgical technique and outcome of orthotopic renal transplantation. Journal of Urology 2001;166:1647-50.
  1. Niedzielski J, Paduch DA. Recurrence of varicocele after high retroperitoneal repair: Implications of intraoperative venography. Journal of Urology 2001;165:937-40.
  1. Paduch DA, Conlin M, Dematos A, et al. Arterial duodenovesical fistula after simultaneous pancreas and kidney transplantation. Journal of Urology 2000;164:1296-.
  1. Vetto J, Jun SY, Paduch D, Eppich H, Shih R. Stages at presentation, prognostic factors, and outcome of breast cancer in males. Am J Surg 1999;177:379-83.
  1. Paduch DA, Niedzielski J, Skoog SJ. Diagnosis, evaluation and treatment of adolescent varicocele. Med Sci Monit 1999;5:1255-67.
  1. Paduch DA, Skoog SJ. Diagnosis, evaluation and treatment of adolescent varicocele. Digital Urology Journal 1997.
  1. Paduch DA, Niedzielski J. Repair versus observation in adolescent varicocele: A prospective study. Journal of Urology 1997;158:1128-32.
  1. Paduch DA, Niedzielski J. Recurrence of varicocele after high retroperitoneal repair - Implications of intraoperative venography. Pediatrics 1997;100:564-5.
  1. Niedzielski J, Paduch D, Raczynski P. Assessment of adolescent varicocele. Pediatric Surgery International 1997;12:410-3.
  1. Barton FF, Hurwitz RS, Fines, et al. Discussion. Journal of Urology 1997;158:1208-9.
  1. Paduch DA, Niedzielski J. Varicocelectomy versus observation in adolescent varicocele: Prospective study. Pediatrics 1996;98:F75-F.
  1. Paduch DA, Niedzielski J. Semen analysis in young men with varicocele: Preliminary study. Journal of Urology 1996;156:788-90
  1. Paduch DA, Godlewski A, Chilarski A. The effects of unilateral testicular torsion on the contralateral testis in Lewis rats. Surg Childh Intern 1995;III:35-40.
  1. Niedzielski J, Paduch DA. Mlodziencze zylaki powrózka nasiennego. [Adolescent varicocele.]. Mag Med 1995:13.

Book chapters:

  1. Paduch, DA, Fuchs, EF: Chapter 9: Office evaluation of male. In "Office Andrology" by Patton, P.E., Bataglia, D.E., Humana Press, 2005 ISBN: 1-58829-318-1
  1. Fuchs, EF, Paduch, DA: Chapter 12: 2005 Vasectomy Reversal. In "Office Andrology", by Patton,P.E., Bataglia, D.E. Humana Press, ISBN: 1-58829-318-1
  1. Paduch, DA, Goldstein, M, Rosenwaks, Z.: Chapter 34: New developments in the evaluation and management of the infertile male., in Male Infertility by Kruger, T and Oehninger, S, 2006, ISBN: 0415397421
  1. Paduch, DA, Schlegel, PN: Chapter: Male hypogonadism. "Essential Pediatric Endocrinology and Metabolism" by Sarafoglou, Kyriakie/ Hoffman, Georg/ Moran, Antoinette, 2009 ISBN: 0071439153
  1. Fine, R, Paduch, DA: Chapter 87: ART in men with Klinefelter Syndrome. "Assisted Reproduction Techniques: Challenges & Management Options", by Sharif, K, and Coomarasamy, A. Wiley-Blackwell 2010, in press

Honors and Awards

AWARDS and HONORS:

· 2nd Place, Best Research, AUA Foundation Research Forum, Chicago, 2009

· Society for Study of Male Reproduction AUA 2009 Research Forum Scholar, Chicago, 2009

· Cook Urology Travel Award, American Society of Andrology, Seattle, 2005

· In-Training Award of American Society for Reproductive Medicine, Philadelphia, 2004

· New Investigator Award, American Society of Andrology, Baltimore, 2004

· Thomas C. Chang Trainee Travel Award, American Society of Andrology, Baltimore, 2004

· Miley B. Wesson Western Section AUA Award, Anchorage, 2001

· Society for Male Reproduction and Urology Traveling Award, Orlando, 2001

· Scholar in Marine Biological Laboratory (Frontiers in Reproduction), Woods Hole, 2001

· Pfizer Scholars in Urology Award, Portland, 2001

· C.V. Hodges Best Resident Paper, Portland, 1999

· AAP, Section on Urology; 1st Place in Clinical Research Prize Award, San Francisco, 1995